Resultados obstétricos y perinatales asociados a la infección por COVID-19: una revisión de la literatura.

Gabriela Valentina Carmach Ananias; Camila Fernanda Escobar Jaramillo

doi:10.22370/rev.mat.1.2021.2509

Resultados obstétricos y perinatales asociados a la infección por COVID-19: una revisión de la literatura.

Matronería Actual ◽

10.22370/rev.mat.1.2021.2509 ◽

2021 ◽

Vol 1 (1) ◽

Author(s):

Gabriela Valentina Carmach Ananias ◽

Camila Fernanda Escobar Jaramillo

Keyword(s):

Placental Pathology

Objetivo: Determinar los resultados obstétricos y/o perinatales que se asocian a la infección por COVID-19, a través de una revisión de la literatura.Metodología: Se realizó una búsqueda avanzada en Pubmed, relacionada con los conceptos paciente e intervención y con los resultados de 67 términos, entre ellos “pregnant”, “newborn”, “Covid-19”, “abortion” y “placental pathology”. Se aplicaron como filtro los años 2019 y 2020 y se encontraron 506 estudios que, a su vez, se filtraron por título, resumen y tipo de estudio, seleccionando aquellos cuya muestra fueran embarazadas y/o neonatos diagnosticados con COVID-19, y que reportaran resultados obstétricos y/o perinatales negativos. Finalmente, se seleccionaron 42. Resultados: Los resultados que destacan por prevalencia o severidad fueron: parto prematuro, patología placentaria, anticuerpos IgM y/o IgG para COVID-19 aumentados en gestantes y recién nacidos, estado fetal no tranquilizador, COVID-19(+) en leche materna, en líquido amniótico o hisopado vaginal, probable transmisión intraparto, ingreso a UCIN, mala perfusión vascular fetal o materna y cesárea por condición materna asociada al virus.Conclusiones: Sugerimos instaurar medidas de prevención oportunas en las gestantes para evitar el contagio por COVID-19 durante y después de la gestación, con el propósito de evitar el riesgo de complicaciones asociadas al virus, las que conllevan importantes consecuencias para la madre y/o el recién nacido.

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Impact of SARS-CoV-2 on the clinical outcomes and placental pathology of pregnant women and their infants: A Systematic Review

Heliyon ◽

10.1016/j.heliyon.2021.e06393 ◽

2021 ◽

pp. e06393

Author(s):

Irina Oltean ◽

Jason Tran ◽

Sarah Lawrence ◽

Brittany Ann Ruschkowski ◽

Na Zeng ◽

...

Keyword(s):

Systematic Review ◽

Pregnant Women ◽

Clinical Outcomes ◽

Placental Pathology

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Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes

Pathogens ◽

10.3390/pathogens10050543 ◽

2021 ◽

Vol 10 (5) ◽

pp. 543

Author(s):

Sergio Gastón Caspe ◽

Javier Palarea-Albaladejo ◽

Clare Underwood ◽

Morag Livingstone ◽

Sean Ranjan Wattegedera ◽

...

Keyword(s):

Disease Outbreaks ◽

Principal Component ◽

Placental Pathology ◽

Wild Type ◽

Cell Infiltrate ◽

Chlamydia Abortus ◽

Vaccine Type ◽

The Difference ◽

Enzootic Abortion Of Ewes

Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to that resulting from a natural wild-type (wt) infection. The aim of this study was to extend these observations by comparing the distribution and severity of the lesions, the composition of the predominating cell infiltrate, the amount of bacteria present and the role of the blood supply in infection. A novel system for grading the histological and pathological features present was developed and the resulting multi-parameter data were statistically transformed for exploration and visualisation through a tailored principal component analysis (PCA) to evaluate the difference between them. The analysis provided no evidence of meaningful differences between vt and wt strains in terms of the measured pathological parameters. The study also contributes a novel methodology for analysing the progression of infection in the placenta for other abortifacient pathogens.

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Placental pathology in an unsuspected case of mucolipidosis type II with secondary hyperparathyroidism in a premature infant

Molecular Genetics and Metabolism Reports ◽

10.1016/j.ymgmr.2021.100747 ◽

2021 ◽

Vol 27 ◽

pp. 100747

Author(s):

Parith Wongkittichote ◽

Garland Michael Upchurch ◽

Louis P. Dehner ◽

Timothy Wood ◽

Jorge L. Granadillo

Keyword(s):

Secondary Hyperparathyroidism ◽

Premature Infant ◽

Type Ii ◽

Placental Pathology ◽

Mucolipidosis Type

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Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling

Pediatric and Developmental Pathology ◽

10.1177/10935266211025122 ◽

2021 ◽

pp. 109352662110251

Author(s):

James Roberts ◽

Jeanette D Cheng ◽

Elizabeth Moore ◽

Carla Ransom ◽

Minhui Ma ◽

...

Keyword(s):

Risk Factors ◽

Case Report ◽

Gestational Age ◽

Small For Gestational Age ◽

Immunohistochemical Staining ◽

Placental Pathology ◽

Fibrin Deposition ◽

Placental Infection ◽

Fetal Infection

Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition.

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