In present work, a series of novel [1,2,4]triazolo[1,5-a]quinoline derivatives (HP-101-110) have been
synthesized using multi-component reaction at room temperature in the presence of ammonium chloride
as mild, cost effective green catalyst along with water as eco-friendly green solvent. The synthesis of
1,2,4-triazolo[1,5-a]quinolines (HP-101-110) was achieved by two step process. In first step, diversified
Hantzsch pyridine reaction of an appropriate aromatic aldehyde, malononitrile, dimedone and benz
hydrazide using ethanol as a solvent gives N-(2-amino-3-cyano-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-
tetrahydro-quinolin-1(4H)-yl)-4-hydroxybenzamide derivatives. In the second step, synthesis of the
final product 2-(4-hydroxyphenyl)-8,8-dimethyl-6-oxo-5-phenyl-6,7,8,9-tetrahydro[1,2,4]triazolo[1,5-
a]-quinoline-4-carbonitriles was achieved by the intramolecular cyclization of step 1 product.The structure
of all the synthesized compounds (HP101-110) has been elucidated by FT-IR, 1H & 13C NMR, mass
spectral data and elemental analyses.
One-pot multicomponent synthesis of thieno[2,3-b]indoles catalyzed by a magnetic nanoparticle-supported [Urea]4[ZnCl2] deep eutectic solvent