scholarly journals Liver Damage in Type 1 Diabetes Mellitus

2021 ◽  
Vol 31 (2) ◽  
pp. 7-13
Author(s):  
A. O. Bueverov ◽  
A. V. Zilov
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Patient Outcomes ◽  
Liver Damage ◽  
Diabetes Type ◽  
Diabetes Type 1 ◽  
Key Points ◽  
Prevention And Treatment

Aim. An up-to-date review of the prevalence, pathogenesis, diagnosis and management of hepatological complications of type 1 diabetes mellitus (T1D).Key points. Diabetes type 1 causes a markedly more common liver injury than traditionally assumed. Three types of hepatic damage have been described to date in T1D patients, steatosis, glycogen hepatopathy and diabetic hepatosclerosis, with the latter two apparently pathognomonic of this diabetes type. Their pathogenesis is complex and not fully understood. Its important link is a likely inherited non-physiological insulin supply to the tissue, especially at marked glycaemic fluctuations. An adequate glycaemic control is the main prevention and treatment measure in these conditions. The practitioner’s understanding of liver damage in T1D is an earnest to avoid unnecessary tests and ineffective medications.Conclusion. Both endocrinologists and internists ought to contemplate the possibility of liver involvement in T1D for improving the patient outcomes.

scholarly journals Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Samar Samir Abdelmajed ◽  
Mohamed A. El-Dessouky ◽  
Doaa S. SalahElDin ◽  
Naglaa Abu-Mandil Hassan ◽  
Moushira Erfan Zaki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Type ◽  
Diabetic Patients ◽  
Diabetes Type 1 ◽  
Anthropometric Parameters ◽  
Immune Disorder ◽  
Egyptian Patients

Abstract Background Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. The current study aimed to clarify the role of STAT4 (rs7574865) variant allelic and genotypic variations in the susceptibility to type 1 diabetes among Egyptians by using the real-time PCR. Results A total of 100 patients and 100 controls were genotyped for rs7574865, and the biochemical and anthropometric parameters were measured to show that type 1 diabetic patients had significantly higher levels of HbA1c and triglycerides compared to non-diabetic individuals (P < 0.05). And genetically, the T allele and GT genotype have a significant correlation with diabetes type 1. Conclusion It was confirmed by this study that the rs7574865 T allele and GT genotype have a significant correlation with diabetes type 1 incidence among Egyptian patients.

Nutrition Practice Guidelines for Type 1 Diabetes Mellitus Positively Affect Dietitian Practices and Patient Outcomes

1998 ◽  
Vol 98 (1) ◽  
pp. 62-70 ◽  
Author(s):  
KARMEEN KULKARNI ◽  
GAY CASTLE ◽  
REBECCA GREGORY ◽  
ALBERTA HOLMES ◽  
CAROLYN LEONTOS ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Patient Outcomes ◽  
Practice Guidelines ◽  
Nutrition Practice

scholarly journals Glycogenic hepatopathy associated with type 1 diabetes mellitus as a cause of recurrent liver damage

2012 ◽  
Vol 11 (4) ◽  
pp. 554-558 ◽  
Author(s):  
Sara Messeri ◽  
Luca Messerini ◽  
Francesco Vizzutti ◽  
Giacomo Laffi ◽  
Fabio Marra
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Liver Damage

Diabetic Ketoacidosis Management

2018 ◽  
pp. 281-284
Author(s):  
Guensley Delva ◽  
Tracey Straker
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis ◽  
Diabetes Type ◽  
Postanesthesia Care Unit ◽  
Diabetes Type 1 ◽  
Past Medical History ◽  
Electrolyte Replacement

Diabetic ketoacidosis (DKA) is an acute complication of diabetes that most often affects patients with type 1 diabetes mellitus. DKA is a form of elevated anion gap metabolic acidosis that results in hyperosmolar diuresis, fatty acid breakdown as a source of alternate energy, and electrolyte changes. Vigilant replacement of intravascular water deficits, glycemic control, and electrolyte replacement is at the centerpiece of effective DKA management. This chapter uses a case study of a 24-year-old female with a past medical history significant for diabetes type 1 and alcohol abuse history who is in the postanesthesia care unit after undergoing surgery for a fractured right arm and is complaining of right quadrant abdominal pain.

scholarly journals The Role of Gene Therapy in the Treatments of Type 1 Diabetes Mellitus: a review

2020 ◽  
Vol 9 (2) ◽  
pp. 57-64
Author(s):  
Harem Othman Smail
Keyword(s):  
Diabetes Mellitus ◽  
Gene Therapy ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Type ◽  
Molecular Medicine ◽  
Treatment And Prevention ◽  
Pancreatic Damage

The main aims of this review were to understand the roles of gene therapy in the treatment and prevention of type 1 diabetes mellitus and I will discuss a brief history, approaches, vector types with the future of diabetes following clinical use. Type 1 diabetes mellitus is a metabolic condition that is identified by insufficient insulin development due to pancreatic damage to beta cells. Control, long life, and diagnosis of these metabolic disorders have become vital sources for many scientists and researchers. After 2000, the latest approaches to molecular medicine were introduced as one of the possible therapeutic options for diabetes type 1 diagnosis. Many genes have been reported as a clinical trial so that damaged genes can be treated and three main approaches shown about 50 years ago are islet transplantation, β cell regeneration, and insulin gene therapy to cure and prevent diabetes type. Treating diabetes through gene therapy can promise children and adolescents, but more clinical applications are needed to recognize it as a permanent route.

Sign in / Sign up

Export Citation Format

Share Document