scholarly journals Relationship between depression, anxiety, and pain perception in diabetic neuropathy

2021 ◽  
Vol 17 (S1) ◽  
pp. 9
Keyword(s):  
Diabetic Neuropathy ◽  
Pain Perception

scholarly journals Awareness about peripheral diabetic neuropathy among physical therapists in twin cities

2019 ◽  
Vol 2 (2) ◽  
pp. 72-76
Author(s):  
Saeeda Taj ◽  
Kinza Anwar ◽  
Abdul Ghafoor Sajjad
Keyword(s):  
Diabetic Neuropathy ◽  
Pain Perception ◽  
Physical Therapists ◽  
Deep Tendon Reflex ◽  
Sampling Technique ◽  
Twin Cities ◽  
Specific Response ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Peripheral Diabetic Neuropathy

Objective: The main purpose of this study was to create awareness of holistic Screening approach about Peripheral Diabetic Neuropathy among Physical Therapists in Twin Cities. A descriptive cross-sectional study conducted at hospitals of Rawalpindi and Islamabad for of 6 months. Methodology: A descriptive cross-sectional survey was carried out and non-probability purposive sampling technique was used to collect data from 110 Physical Therapists (58.1% females and 41.8% Males. A specified semi structured questionnaire was used to collect data from Physical Therapists. Results: This study was carried out on 110 Physical Therapists. Results of our study showed that 94 (85.5%) Physical Therapists screened patients with different modalities such as 7 (6.4%) used touch perception, 6 (5.5%) used pain perception, 2 (1.8%) used vibration perception and only 1 (.9%) used ankle deep tendon reflex. 97 (88.2%) Physical Therapists assessed pain by different methods such as Pin prick method was used by 67 (60.9%) therapist, VAS was used by 15 (13.6%) therapists, 87 (79.1%) Physical Therapists assessed touch sensation. 21 (19.1%), used cotton ball, 5 (4.5%) used manual touch while 41 (37.3%) were having no specific response. Conclusion: It is concluded that Physical Therapists of twin cities are aware of basic screening steps for Peripheral Diabetic Neuropathy and they utilize appropriate tool/modalities for assessing sensations and motor reflexes. This highlight the up to date evidence-based knowledge of PT working in twin cities.

Tanshinone IIA Improves Painful Diabetic Neuropathy by Suppressing the Expression and Activity of Voltage-Gated Sodium Channel in Rat Dorsal Root Ganglia

2018 ◽  
Vol 126 (10) ◽  
pp. 632-639
Author(s):  
Ao Ri-Ge-le ◽  
Zhuang-Li Guo ◽  
Qi Wang ◽  
Bao-Jian Zhang ◽  
Da-Wei Kong ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Dorsal Root ◽  
Pain Perception ◽  
Salvia Miltiorrhiza ◽  
Thermal Hyperalgesia ◽  
Diabetic Rats ◽  
Tanshinone Iia ◽  
Painful Diabetic Neuropathy ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels

AbstractPainful diabetic neuropathy (PDN) is one of the intractable complications of diabetes mellitus, which manifest as exaggerated pain perception. Previous studies showed that Tanshinone IIA (TIIA), one of the major bioactive extracts of Salvia miltiorrhiza Bunge, have obvious analgesic effect on different types of pain process, and the underlying analgesic mechanisms are not fully understood. The present study combined the behavioral, electrophysiological and biochemical methods to elucidate the analgesic mechanism of TIIA, using streptozotocin (STZ)-induced PDN rat models. Intraperitoneal injection (i.p.) of TIIA for 3 weeks in PDN rats significantly improved mechanical allodynia and thermal hyperalgesia. Patch clamp recordings showed that the excitability of dorsal root ganglion (DRG) nociceptive neuron was increased in diabetic state, and TIIA treatment effectively recovered the subnormality, which was achieved by preventing augments of both Tetrodotoxin-sensitive (TTX-resistant) and Tetrodotoxin-sensitive (TTX-S) sodium currents. Further, the protein expressions of voltage-gated sodium channels (VGSCs) α-subunits Nav1.3, Nav1.7 and Nav1.9 increased in DRG of diabetic rats and were normalized by TIIA application. In conclusion, this study provides evidence that the TIIA attenuated PDN by effecting VGSCs activities and expressions, indicating that the TIIA could be a promising agent for PDN treatment.

scholarly journals Diabetic neuropathy is associated with increased pain perception, low serum beta-endorphin and increase insulin resistance among Nigerian cohorts in Ekiti State

Heliyon ◽  
2020 ◽  
Vol 6 (7) ◽  
pp. e04377
Author(s):  
Olabode O. Akintoye ◽  
Bamidele V. Owoyele ◽  
Oyesanmi A. Fabunmi ◽  
Taiwo H. Raimi ◽  
Adesola A. Oniyide ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Diabetic Neuropathy ◽  
Pain Perception ◽  
Beta Endorphin ◽  
Increase Insulin Resistance ◽  
Low Serum

Critical Evaluation of Mouse Models Used to Study Pain and Loss of Pain Perception in Diabetic Neuropathy

2012 ◽  
Vol 120 (04) ◽  
pp. 188-190 ◽  
Author(s):  
A. Bierhaus ◽  
P. Nawroth
Keyword(s):  
Diabetic Neuropathy ◽  
Mouse Models ◽  
Molecular Mechanisms ◽  
Pain Perception ◽  
Critical Evaluation ◽  
Knock Out ◽  
Background Strain ◽  
And Gender ◽  
To Receive ◽  
Diabetes Induction

AbstractA number of studies have addressed diabetic neuropathy (DN) in transgenic and knock out mouse models to unravel the molecular mechanisms underlying metabolic pain and loss of pain perception. However, it is difficult to compare these studies with each other or even with human DN due to experimental differences including the type of diabetes, the background strain of the respective mouse model, the methods of diabetes induction and the duration of diabetes, animal age and gender. To receive useful information for DN from genetically modified mice, it is therefore mandatory to first define the appropriate model and – if necessary – to backcross transgenic strains into the respective background to allow a reliable (and at least in part translatable to human DN) interpretation of the results.

Evaluation of SET–A New Device for the Measurement of Pain Perception in Comparison to Standard Measures of Diabetic Neuropathy

2004 ◽  
Vol 6 (5) ◽  
pp. 601-606 ◽  
Author(s):  
Mai Nguyen ◽  
Wolfgang Henniges ◽  
Michael Lobisch ◽  
Silvia Reifert ◽  
Martin Larbig ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Pain Perception ◽  
New Device

Bladder decompensation correlates with diabetic neuropathy

JAMA ◽  
1966 ◽  
Vol 197 (7) ◽  
pp. 39b-39 ◽  
Author(s):  
M. Ellenberg
Keyword(s):  
Diabetic Neuropathy

Chronic Pain: Fundamental Scientific Considerations, Specifically for Legal Claims

2013 ◽  
Vol 18 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Robert J. Barth
Keyword(s):  
Health Outcomes ◽  
Pain Perception ◽  
Driving Forces ◽  
Psychological Treatment ◽  
Dominant Role ◽  
Meta Analysis ◽  
General Medicine ◽  
Pain Syndrome ◽  
Problematic Relationship

Abstract Scientific findings have indicated that psychological and social factors are the driving forces behind most chronic benign pain presentations, especially in a claim context, and are relevant to at least three of the AMA Guides publications: AMA Guides to Evaluation of Disease and Injury Causation, AMA Guides to Work Ability and Return to Work, and AMA Guides to the Evaluation of Permanent Impairment. The author reviews and summarizes studies that have identified the dominant role of financial, psychological, and other non–general medicine factors in patients who report low back pain. For example, one meta-analysis found that compensation results in an increase in pain perception and a reduction in the ability to benefit from medical and psychological treatment. Other studies have found a correlation between the level of compensation and health outcomes (greater compensation is associated with worse outcomes), and legal systems that discourage compensation for pain produce better health outcomes. One study found that, among persons with carpal tunnel syndrome, claimants had worse outcomes than nonclaimants despite receiving more treatment; another examined the problematic relationship between complex regional pain syndrome (CRPS) and compensation and found that cases of CRPS are dominated by legal claims, a disparity that highlights the dominant role of compensation. Workers’ compensation claimants are almost never evaluated for personality disorders or mental illness. The article concludes with recommendations that evaluators can consider in individual cases.

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