scholarly journals Analysis and Optimal Design of Batch and Two-Column Continuous Chromatographic Frontal Processes for Monoclonal Antibody Purification

2020 ◽  
Author(s):  
Ce Shi ◽  
Sebastian Vogg ◽  
Dong-Qiang Lin ◽  
Mattia Sponchioni ◽  
Massimo Morbidelli
Keyword(s):  
Continuous Process ◽  
Therapeutic Proteins ◽  
Design Procedure ◽  
Downstream Processing ◽  
Antibody Purification ◽  
Cation Exchange Resins ◽  
Frontal Processes ◽  
Exchange Resins ◽  
Downstream Processes ◽  
Frontal Chromatography

Frontal chromatography has seen increased interest for protein purification, in particular as a polishing step in downstream processes for therapeutic proteins production, as for example the purification of monoclonal antibodies (mAbs) from high molecular weight impurities, e.g., aggregates, using cation exchange resins. In this work we introduce a new two-column continuous process implementing frontal chromatography. The design procedure and its performance, compared to classical batch technology, are discussed. This represents an additional option in the realisation of optimised continuous downstream processing of therapeutic proteins.

Study on the Alkoxylation of Dihydromyrcene over Cation Exchange Resins

2019 ◽  
Vol 58 (27) ◽  
pp. 11871-11877 ◽  
Author(s):  
Si Chen ◽  
Su Wang ◽  
Zheng Zhou ◽  
Gaodong Yang ◽  
Zhibing Zhang
Keyword(s):  
Cation Exchange ◽  
Cation Exchange Resins ◽  
Exchange Resins

Factor analysis of trends in selectivity in gas-solid chromatography on cation-exchange resins

1980 ◽  
Vol 52 (4) ◽  
pp. 723-728 ◽  
Author(s):  
Roland F. Hirsch ◽  
Robert J. Gaydosh ◽  
Jacques R. Chretien
Keyword(s):  
Factor Analysis ◽  
Cation Exchange ◽  
Cation Exchange Resins ◽  
Exchange Resins

Gas-solid chromatography on cation-exchange resins

1981 ◽  
Vol 207 (1) ◽  
pp. 115-130 ◽  
Author(s):  
Jacques R. Chrétien ◽  
Jacques-Emile Dubois ◽  
Roland F. Hirsch ◽  
Robert J. Gaydosh
Keyword(s):  
Cation Exchange ◽  
Cation Exchange Resins ◽  
Exchange Resins

CONSERVATIVE MANAGEMENT OF ACUTE RENAL FAILURE

PEDIATRICS ◽  
1960 ◽  
Vol 25 (3) ◽  
pp. 409-418
Author(s):  
S. A. Kaplan ◽  
J. Strauss ◽  
A. M. Yuceoglu
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Fluid Intake ◽  
Sodium Intake ◽  
Caloric Intake ◽  
Urine Volume ◽  
Proximal Tubules ◽  
Cation Exchange Resins ◽  
Exchange Resins ◽  
Insensible Loss

The observations during treatment of three children with acute renal failure by a conservative regimen of therapy are presented. One patient died. The regimen has also been applied to six adults with renal failure; one died. The urine in the early stages of renal failure may be iso-osmotic with plasma and may represent unmodified fluid from the proximal tubules. Cardiac failure associated with hyperkalemia or administration of excessive quantities of fluids is the most frequent cause of death in this disorder. A regimen of therapy is described which embodies the following principles: a) Limitation of daily fluid intake to insensible loss plus the urine volume of the previous day. b) Restriction of sodium intake from the beginning to anticipate the development of acidosis. c) Use of cation exchange resins to prevent excessive increase in the concentration of potassium in the serum. d) Provision of adequate caloric intake through the administration of emulsified fat intravenously. e) Treatment of hyperphosphatemia and hypocalcemia when they occur. f) Continuation of careful supervision and therapy, even after the diuretic phase begins, since renal function continues to be severely restricted for several days afterwards.

scholarly journals Leachables from Strong Acid Cation Exchange Resins

1988 ◽  
Vol 37 (12) ◽  
pp. 1114-1121 ◽  
Author(s):  
Wataru AGUI ◽  
Masahito TAKEUCHI ◽  
Masahiko ABE ◽  
Keizo OGINO
Keyword(s):  
Cation Exchange ◽  
Strong Acid ◽  
Cation Exchange Resins ◽  
Acid Cation ◽  
Exchange Resins
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