Effect of temperature on the morphology of bubble-electrospun nanofibers

The morphology and microstructures of poly(vinyl alcohol) and poly(vinyl pyrrolidone) nanofibers produced by bubble-electrospinning are investigated experimentally. It is shown that the temperature predominantly affect the average diameters of the formed nanofibers. The smooth surface and controllable diameters of nanofibers are essential for their applications in different temperature environment.

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Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release

Biomaterials ◽

10.1016/j.biomaterials.2003.10.035 ◽

2004 ◽

Vol 25 (17) ◽

pp. 3773-3782 ◽

Cited By ~ 109

Author(s):

Amedea Barozzi Seabra ◽

Marcelo Ganzarolli de Oliveira

Keyword(s):

Nitric Oxide ◽

Vinyl Alcohol ◽

Vinyl Pyrrolidone ◽

Poly Vinyl Alcohol ◽

Nitric Oxide Release ◽

Poly Vinyl Pyrrolidone

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PREPARATION AND CHARACTERIZATION OF POLY (VINYL ALCOHOL)–POLY (VINYL PYRROLIDONE) MUCOADHESIVE BUCCAL PATCHES FOR DELIVERY OF LIDOCAINE HCL

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2018v10i1.23208 ◽

2018 ◽

Vol 10 (1) ◽

pp. 115 ◽

Cited By ~ 5

Author(s):

Napaphak Jaipakdee ◽

Thaned Pongjanyakul ◽

Ekapol Limpongsa

Keyword(s):

Vinyl Alcohol ◽

Vinyl Pyrrolidone ◽

Poly Vinyl Alcohol ◽

Scanning Calorimetry ◽

X Ray ◽

Casting Technique ◽

In Vitro Permeation ◽

Lidocaine Hcl ◽

Poly Vinyl Pyrrolidone

Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix.Conclusion: Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.

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