Coagulation Assay and Stroke Severity upon Admission of Patients with Cardioembolic Cerebral Infarction during Direct Oral Anticoagulant Use

The relationship between stroke severity and prior direct oral anticoagulant therapy in patients with acute ischaemic stroke and non-valvular atrial fibrillation

European Journal of Neurology ◽

10.1111/ene.13405 ◽

2017 ◽

Vol 24 (11) ◽

pp. 1399-1406 ◽

Cited By ~ 11

Author(s):

Y. Sakamoto ◽

S. Okubo ◽

C. Nito ◽

S. Suda ◽

N. Matsumoto ◽

...

Keyword(s):

Atrial Fibrillation ◽

Ischaemic Stroke ◽

Anticoagulant Therapy ◽

Acute Ischaemic Stroke ◽

Oral Anticoagulant ◽

Oral Anticoagulant Therapy ◽

Stroke Severity ◽

Direct Oral Anticoagulant ◽

The Relationship

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Stroke severity in patients with preceding direct oral anticoagulant therapy as compared to vitamin K antagonists

Journal of Neurology ◽

10.1007/s00415-019-09412-y ◽

2019 ◽

Vol 266 (9) ◽

pp. 2263-2272 ◽

Cited By ~ 4

Author(s):

Elias Auer ◽

Sebastién Frey ◽

Johannes Kaesmacher ◽

Arsany Hakim ◽

David J. Seiffge ◽

...

Keyword(s):

Anticoagulant Therapy ◽

Vitamin K ◽

Oral Anticoagulant ◽

Oral Anticoagulant Therapy ◽

Vitamin K Antagonists ◽

Stroke Severity ◽

Direct Oral Anticoagulant

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Cancer-associated cerebral infarction during direct oral anticoagulant treatment in cancer patients: a case series

International Cancer Conference Journal ◽

10.1007/s13691-019-00370-w ◽

2019 ◽

Vol 8 (3) ◽

pp. 130-135

Author(s):

Takuya Oyakawa ◽

Hiroyuki Fukuda ◽

Nao Muraoka ◽

Kei Iida ◽

Masatoshi Kusuhara

Keyword(s):

Cerebral Infarction ◽

Cancer Patients ◽

Oral Anticoagulant ◽

Case Series ◽

Direct Oral Anticoagulant ◽

Anticoagulant Treatment ◽

Oral Anticoagulant Treatment

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Adequate Adherence to Direct Oral Anticoagulant is Associated with Reduced Ischemic Stroke Severity in Patients with Atrial Fibrillation

Journal of Stroke and Cerebrovascular Diseases ◽

10.1016/j.jstrokecerebrovasdis.2018.09.019 ◽

2019 ◽

Vol 28 (6) ◽

pp. 1773-1780 ◽

Cited By ~ 5

Author(s):

Kazuo Yamashiro ◽

Naohide Kurita ◽

Ryota Tanaka ◽

Yuji Ueno ◽

Nobukazu Miyamoto ◽

...

Keyword(s):

Atrial Fibrillation ◽

Ischemic Stroke ◽

Oral Anticoagulant ◽

Stroke Severity ◽

Direct Oral Anticoagulant

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Abstract WP246: Characteristic of Ischemic Stroke Prior Taking Direct Oral Anticoagulant versus Warfarin Treatment: Results From the PASTA Registry

Stroke ◽

10.1161/str.51.suppl_1.wp246 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Satoshi Suda ◽

Yasuyuki Iguchi ◽

Shigeru Fujimoto ◽

Yoshiki Yagita ◽

Takayuki Mizunari ◽

...

Keyword(s):

Oral Anticoagulant ◽

Clinical Characteristics ◽

Low Dose ◽

Favorable Outcome ◽

Stroke Severity ◽

Direct Oral Anticoagulant ◽

Stroke Patients ◽

Nihss Score ◽

Large Size ◽

Warfarin Treatment

Background and Purpose: The characteristics of patients with stroke prior receiving direct oral anticoagulant (DOAC) have not been fully clarified. We planned to recruit patients prospectively and to investigate the characteristics and outcomes in stroke patients taking DOAC and warfarin treatment prior to the event. Methods: The prospective analysis of stroke patients taking anticoagulants (PASTA) registry study is an observational, multicenter, prospective registry of stroke patients receiving OAC. Patient enrollment started in April 2016 at 25 tertiary centers across Japan. We compared clinical characteristics and discharge modified Rankin Scale (mRS) between DOAC-and warfarin-treatment in patients with atrial fibrillation (AF). Results: A total of 580 patients (231 women; median age 80 [quartiles 73-84] years) were analyzed (Fig. A). Of these, 365 patients (63%) received prior DOAC treatment and the remaining 215 (37%) received prior warfarin treatment (Fig. B and C). There were significant differences in clinical characteristics and outcome between DOAC-and warfarin-treatment prior to the event regarding initial NIHSS score (median [quartiles]: DOAC, 4 [2-16] vs. warfarin, 9 [3-21]; P =0.0001), rate of medium-large size of infarct (DOAC, 202/340 [59%] versus warfarin, 152/203 [75%]; P =0.0003) and the proportion of patients with favorable outcome (mRS, 0-3: DOAC 218/354 [62%] vs. warfarin 108/212 [49%]; P =0.0036). Subclassification according to DOAC dosing revealed patients with low-dose (259/365; 71%) to be older and to have a higher NIHSS score compared with regular dose (low-dose, 5 [2-17] vs. regular-dose, 3 [1-11]; P =0.0023) (Fig. D). Type of DOAC agent did not result in relevant differences in clinical characteristics or outcome (Fig. E). Conclusions: Our results showed that patients with DOAC treatment before the event showed smaller infarct size, milder initial stroke severity, and favorable outcome compared to patients with warfarin.

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