89 GENE THERAPY: POTENT CYTOTOXIC T LYMPHOCYTE ACTIVITY BY ADENO-ASSOCIATED VIRUS/CORE-HEPATITIS C VIRUS GENE DELIVERY INTO DENDRITIC CELLS.

2006 ◽  
Vol 54 (1) ◽  
pp. S271.6-S271
Author(s):  
M. Chiriva-Internati ◽  
F. Grizzi ◽  
E. Frezza ◽  
E. Cobos
Keyword(s):  
Gene Therapy ◽  
Dendritic Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Gene Delivery ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Adeno Associated Virus ◽  
Virus Core ◽  
Lymphocyte Activity

Comparison of cytotoxic T-lymphocyte responses to hepatitis C virus core protein in uninfected and infected individuals

1999 ◽  
Vol 58 (3) ◽  
pp. 239-246 ◽  
Author(s):  
Margaret Jackson ◽  
Belinda Smith ◽  
Debra J. Bevitt ◽  
Michael Steward ◽  
Geoffrey L. Toms ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocyte ◽  
Core Protein ◽  
Cytotoxic T Lymphocyte ◽  
Virus Core ◽  
Lymphocyte Responses

scholarly journals Intrahepatic hepatitis C virus-specific cytotoxic T lymphocyte activity and response to interferon alfa therapy in chronic hepatitis C

Hepatology ◽  
1998 ◽  
Vol 28 (1) ◽  
pp. 225-230 ◽  
Author(s):  
David R. Nelson ◽  
Constantine G. Marousis ◽  
Tomoyoshi Ohno ◽  
Gary L. Davis ◽  
Johnson Y.N. Lau
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Interferon Alfa ◽  
Lymphocyte Activity

Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity

1998 ◽  
Vol 115 (4) ◽  
pp. 954-966 ◽  
Author(s):  
Sun-Lung Tsai ◽  
Young-Mao Chen ◽  
Ming-Huei Chen ◽  
Chao-Yuan Huang ◽  
I-Shyan Sheen ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Activity

Impaired cytotoxic T lymphocyte inductivity by dendritic cells derived from patients with hepatitis C virus-positive hepatocellular carcinoma

2007 ◽  
Vol 37 (4) ◽  
pp. 276-285 ◽  
Author(s):  
Tomoyoshi Ohno ◽  
Noboru Hirashima ◽  
Etsuro Orito ◽  
Izumi Hasegawa ◽  
Kei Fujiwara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dendritic Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte

scholarly journals Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 ◽  
Vol 191 (9) ◽  
pp. 1499-1512 ◽  
Author(s):  
Franziska Lechner ◽  
David K.H. Wong ◽  
P. Rod Dunbar ◽  
Roger Chapman ◽  
Raymond T. Chung ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Acute Infection ◽  
Hcv Infection ◽  
Ctl Response ◽  
Acute Hcv ◽  
Ifn Γ ◽  
Acute Hcv Infection

Although hepatitis C virus (HCV) infection is very common, identification of patients during acute infection is rare. Consequently, little is known about the immune response during this critical stage of the disease. We analyzed the T lymphocyte response during and after acute resolving HCV infection in three persons, using interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) and human histocompatibility leukocyte antigen (HLA) peptide tetramer assays. Acute infection was associated with a broadly directed T helper and cytotoxic T lymphocyte (CTL) response, which persisted after resolution of clinical hepatitis and clearance of viremia. At the earliest time point studied, highly activated CTL populations were observed that temporarily failed to secrete IFN-γ, a “stunned” phenotype, from which they recovered as viremia declined. In long-term HCV-seropositive persons, CTL responses were more common in persons who had cleared viremia compared with those with persistent viremia, although the frequencies of HCV-specific CTLs were lower than those found in persons during and after resolution of acute HCV infection. These studies demonstrate a strong and persistent CTL response in resolving acute HCV infection, and provide rationale to explore immune augmentation as a therapeutic intervention in chronic HCV infection.

Induction of Strong Cytotoxic T-Lymphocyte Responses to Hepatitis C Virus with Recombinant Poly-epitope in BALB/c Mice

2006 ◽  
Vol 19 (1) ◽  
pp. 64-73 ◽  
Author(s):  
J. Yan ◽  
S. Ling ◽  
H. Liu ◽  
H. Zhang ◽  
X. Song ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Responses
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