Clinical Pharmacology

2020 ◽  
Author(s):  
Molly Droege ◽  
Eric W. Mueller
Keyword(s):  
Clinical Pharmacology ◽  
Critically Ill ◽  
Adverse Drug Reactions ◽  
Therapeutic Interventions ◽  
Surgical Patients ◽  
Therapeutic Drug ◽  
Drug Reactions ◽  
Organ Function ◽  
Key Factor ◽  
Critically Ill Surgical Patients

Critically ill patients often require surgical procedures and therapeutic interventions that produce significant pathophysiologic changes. Drug pharmacology can be greatly altered in this population wherein comorbid diseases, varied organ function, and polypharmacy can produce adverse drug reactions (ADRs). This review aims to describe basic pharmacokinetic principles (absorption, distribution, metabolism, elimination) and changes in these processes due to altered organ function in critically ill surgical patients. This knowledge is a key factor in reducing ADRs. This review contains 10 figures, 2 tables, 101 references Keywords: adverse drug reactions, drug interactions, obesity, pharmacodynamics, pharmacokinetics, plasma protein binding, therapeutic drug monitoring  

Clinical Pharmacology

2020 ◽  
Author(s):  
Molly Droege ◽  
Eric W. Mueller
Keyword(s):  
Clinical Pharmacology ◽  
Critically Ill ◽  
Adverse Drug Reactions ◽  
Therapeutic Interventions ◽  
Surgical Patients ◽  
Therapeutic Drug ◽  
Drug Reactions ◽  
Organ Function ◽  
Key Factor ◽  
Critically Ill Surgical Patients

Critically ill patients often require surgical procedures and therapeutic interventions that produce significant pathophysiologic changes. Drug pharmacology can be greatly altered in this population wherein comorbid diseases, varied organ function, and polypharmacy can produce adverse drug reactions (ADRs). This review aims to describe basic pharmacokinetic principles (absorption, distribution, metabolism, elimination) and changes in these processes due to altered organ function in critically ill surgical patients. This knowledge is a key factor in reducing ADRs. This review contains 10 figures, 2 tables, 101 references Keywords: adverse drug reactions, drug interactions, obesity, pharmacodynamics, pharmacokinetics, plasma protein binding, therapeutic drug monitoring  

Clinical Pharmacology

2020 ◽  
Author(s):  
Molly Droege ◽  
Eric W. Mueller
Keyword(s):  
Clinical Pharmacology ◽  
Critically Ill ◽  
Adverse Drug Reactions ◽  
Therapeutic Interventions ◽  
Surgical Patients ◽  
Therapeutic Drug ◽  
Drug Reactions ◽  
Organ Function ◽  
Key Factor ◽  
Critically Ill Surgical Patients

Critically ill patients often require surgical procedures and therapeutic interventions that produce significant pathophysiologic changes. Drug pharmacology can be greatly altered in this population wherein comorbid diseases, varied organ function, and polypharmacy can produce adverse drug reactions (ADRs). This review aims to describe basic pharmacokinetic principles (absorption, distribution, metabolism, elimination) and changes in these processes due to altered organ function in critically ill surgical patients. This knowledge is a key factor in reducing ADRs. This review contains 10 figures, 2 tables, 101 references Keywords: adverse drug reactions, drug interactions, obesity, pharmacodynamics, pharmacokinetics, plasma protein binding, therapeutic drug monitoring  

Drug Allergy

2012 ◽  
Vol 5 (6) ◽  
pp. 319-324
Author(s):  
Helen E. Smith
Keyword(s):  
Adverse Drug Reactions ◽  
Drug Allergy ◽  
Therapeutic Drug ◽  
Drug Reactions ◽  
Immune Mediated ◽  
Allergy Drug ◽  
The Way

Adverse drug reactions are a major cause of morbidity, complicating over 5% of therapeutic drug courses. The majority of these events are due to common predictable mechanisms linked to the way the drug works, but about 5% of all reactions are immune-mediated and constitute true allergy. Drug allergy is one of the potential causes of anaphylaxis, angioedema and urticaria and should always be considered when a patient presents with one of these conditions.

Group II phospholipase A2 in serum in critically ill surgical patients

1994 ◽  
Vol 22 (6) ◽  
pp. 956-959 ◽  
Author(s):  
JUHA M. GröNROOS ◽  
KARI KUTTILA ◽  
TIMO J. NEVALAJNEN
Keyword(s):  
Phospholipase A2 ◽  
Critically Ill ◽  
Surgical Patients ◽  
Group Ii ◽  
Critically Ill Surgical Patients

Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China*

2007 ◽  
Vol 35 (11) ◽  
pp. 2538-2546 ◽  
Author(s):  
Baoli Cheng ◽  
Guohao Xie ◽  
ShangLong Yao ◽  
Xinmin Wu ◽  
Qulian Guo ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Critically Ill ◽  
Surgical Patients ◽  
University Hospitals ◽  
Critically Ill Surgical Patients

Vitamin D Status Is Associated With Development of Hospital-Acquired Pressure Injuries in Critically Ill Surgical Patients

2018 ◽  
Vol 34 (1) ◽  
pp. 142-147 ◽  
Author(s):  
Tiffany M. N. Otero ◽  
Cecilia Canales ◽  
D. Dante Yeh ◽  
Ali Elsayes ◽  
Donna M. Belcher ◽  
...  
Keyword(s):  
Vitamin D ◽  
Critically Ill ◽  
Surgical Patients ◽  
Vitamin D Status ◽  
Hospital Acquired ◽  
Critically Ill Surgical Patients
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