Automatic Skeletal Bone Age Assessment: State of the Art and Future Directions

Author(s):  
Isaak Kavasidis ◽  
Carmelo Pino ◽  
Edoardo Sicurezza
Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 765
Author(s):  
Mohd Asyraf Zulkifley ◽  
Nur Ayuni Mohamed ◽  
Siti Raihanah Abdani ◽  
Nor Azwan Mohamed Kamari ◽  
Asraf Mohamed Moubark ◽  
...  

Skeletal bone age assessment using X-ray images is a standard clinical procedure to detect any anomaly in bone growth among kids and babies. The assessed bone age indicates the actual level of growth, whereby a large discrepancy between the assessed and chronological age might point to a growth disorder. Hence, skeletal bone age assessment is used to screen the possibility of growth abnormalities, genetic problems, and endocrine disorders. Usually, the manual screening is assessed through X-ray images of the non-dominant hand using the Greulich–Pyle (GP) or Tanner–Whitehouse (TW) approach. The GP uses a standard hand atlas, which will be the reference point to predict the bone age of a patient, while the TW uses a scoring mechanism to assess the bone age using several regions of interest information. However, both approaches are heavily dependent on individual domain knowledge and expertise, which is prone to high bias in inter and intra-observer results. Hence, an automated bone age assessment system, which is referred to as Attention-Xception Network (AXNet) is proposed to automatically predict the bone age accurately. The proposed AXNet consists of two parts, which are image normalization and bone age regression modules. The image normalization module will transform each X-ray image into a standardized form so that the regressor network can be trained using better input images. This module will first extract the hand region from the background, which is then rotated to an upright position using the angle calculated from the four key-points of interest. Then, the masked and rotated hand image will be aligned such that it will be positioned in the middle of the image. Both of the masked and rotated images will be obtained through existing state-of-the-art deep learning methods. The last module will then predict the bone age through the Attention-Xception network that incorporates multiple layers of spatial-attention mechanism to emphasize the important features for more accurate bone age prediction. From the experimental results, the proposed AXNet achieves the lowest mean absolute error and mean squared error of 7.699 months and 108.869 months2, respectively. Therefore, the proposed AXNet has demonstrated its potential for practical clinical use with an error of less than one year to assist the experts or radiologists in evaluating the bone age objectively.


2019 ◽  
Vol 15 (1) ◽  
pp. 1-6
Author(s):  
Chadaporn Keatmanee ◽  
Songphon Klabwong ◽  
Kamolphong Osatavanichvong ◽  
Chirotchana Suchato

2017 ◽  
Vol 36 ◽  
pp. 41-51 ◽  
Author(s):  
C. Spampinato ◽  
S. Palazzo ◽  
D. Giordano ◽  
M. Aldinucci ◽  
R. Leonardi

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 781
Author(s):  
Muhammad Waqas Nadeem ◽  
Hock Guan Goh ◽  
Abid Ali ◽  
Muzammil Hussain ◽  
Muhammad Adnan Khan ◽  
...  

Deep learning is a quite useful and proliferating technique of machine learning. Various applications, such as medical images analysis, medical images processing, text understanding, and speech recognition, have been using deep learning, and it has been providing rather promising results. Both supervised and unsupervised approaches are being used to extract and learn features as well as for the multi-level representation of pattern recognition and classification. Hence, the way of prediction, recognition, and diagnosis in various domains of healthcare including the abdomen, lung cancer, brain tumor, skeletal bone age assessment, and so on, have been transformed and improved significantly by deep learning. By considering a wide range of deep-learning applications, the main aim of this paper is to present a detailed survey on emerging research of deep-learning models for bone age assessment (e.g., segmentation, prediction, and classification). An enormous number of scientific research publications related to bone age assessment using deep learning are explored, studied, and presented in this survey. Furthermore, the emerging trends of this research domain have been analyzed and discussed. Finally, a critical discussion section on the limitations of deep-learning models has been presented. Open research challenges and future directions in this promising area have been included as well.


2012 ◽  
Vol 5 (1) ◽  
pp. 90-96 ◽  
Author(s):  
P. Thangam ◽  
◽  
T. V. Mahendiran ◽  
K. Thanushkodi ◽  
◽  
...  

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