During the 20th century, both dental materials and dental technologies for the fabrication of dental prosthesis progressed remarkably. Owing to the increased demand of safety and aesthetics, 3 mol% yttria stabilized tetragonal zirconia polycrystalline has been recently introduced in prosthetic dentistry for the fabrication of crowns and fixed partial dentures, in combination with CAD/CAM technique. This greatly changed the conventional dental laboratory work which is labor-intensive and experience-dependent. This review mainly introduced the state of dental zirconia and the application of CAD/CAM technology in dentistry. Key words: Dental Zirconia; CAD/CAM Technique; Mechanical Properties; Transformation Toughing; Low Temperature Aging;