Administration of Sarpogrelate Hydrochloride for Allergic Vasculitis.

1996 ◽  
Vol 58 (1) ◽  
pp. 16-18
Author(s):  
Kazuyo MAEKAWA ◽  
Kimiko TAKEI ◽  
Kayo TAIRA ◽  
Takeo AOKI ◽  
Hiroshi UESATO ◽  
...  
Keyword(s):  
Sarpogrelate Hydrochloride ◽  
Allergic Vasculitis

Systemic "allergic" vasculitis. Clinical and pathological relationships

JAMA ◽  
1965 ◽  
Vol 194 (10) ◽  
pp. 1059-1064 ◽  
Author(s):  
R. P. McCombs
Keyword(s):  
Allergic Vasculitis

Allergic vasculitis Gougerot-Ruiter syndrome

1967 ◽  
Vol 95 (1) ◽  
pp. 23-27 ◽  
Author(s):  
S. G. Stringa
Keyword(s):  
Allergic Vasculitis

A Case of Allergic Vasculitis Associated with Purpura Scattered over His Face, Congenitally Corrected Transposition and HCV Infection.

1997 ◽  
Vol 59 (5) ◽  
pp. 678-682 ◽  
Author(s):  
Yasuyuki SAWADA ◽  
Kiyomi SOEJIMA ◽  
Toshiyuki YAMAMOTO ◽  
Hiroo YOKOZEKI ◽  
Kiyoshi NISHIOKA ◽  
...  
Keyword(s):  
Hcv Infection ◽  
Allergic Vasculitis ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

Tuberculosis of the meninges and central nervous system. Experience of clinical diagnostics in St. Petersburg for 50 years

MedAlliance ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 14-24
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Medical Errors ◽  
Clinical Diagnostics ◽  
Lethal Outcome ◽  
Significant Difference ◽  
Group 2 ◽  
Allergic Vasculitis ◽  
Tuberculosis Meningitis ◽  
Group 1

The clinic and diagnostics of tuberculosis meningitis (TM) in 926 patients treated in St. Petersburg hospitals in 1965–1994 (group 1) and in 1995–2018 (group 2) is presented. The TM clinic is demonstrated to be determined by the form of tuberculosis and its characteristic generalization nature in the presence of repeated waves of bacteremia and allergic vasculitis of greater or lesser severity. There is clinical peculiarity of TM in primary pulmonary tuberculosis and its early large-focal and late miliar generalization, as well as in hematogenous tuberculosis. In patients of the 1st and 2nd groups the TM clinic shows in some respects a noticeable similarity, in others — a significant difference. Despite the typical symptoms, early diagnosis of TM took place in less than 20% of patients. Clinical examples illustrating the unusual development of TM, contrasting with its usual course, are given. A number of objective and subjective factors contributing to the adverse evolution of TM and its lethal outcome are discussed. These include the peculiarity of modern tuberculosis, especially when associated with HIV infection, as well as medical errors associated with ignorance of the pathogenesis of tuberculosis and failure to comply with the minimum examination for tuberculosis.

In vitro inhibitory effect of sarpogrelate hydrochloride on serotonin-induced platelet small-aggregate formation

2000 ◽  
Vol 60 (2) ◽  
pp. 81-86 ◽  
Author(s):  
Akira Suehiro ◽  
Mikio Marumo ◽  
Hiroshi Yoshimoto ◽  
Satoshi Higasa ◽  
Eizo Kakishita
Keyword(s):  
Inhibitory Effect ◽  
Aggregate Formation ◽  
Small Aggregate ◽  
Sarpogrelate Hydrochloride

DEVELOPMENT AND VALIDATION OF RP-HPLC-PDA METHOD FOR THE ESTIMATION OF SARPOGRELATE HYDROCHLORIDE IN BULK AND DOSAGE FORMS

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (04) ◽  
pp. 77-80
Author(s):  
M Vijaya Lakshmi ◽  
◽  
K Hima Bindu ◽  
M. Pravallika ◽  
B. N. Nalluri
Keyword(s):  
Dosage Forms ◽  
Hplc Method ◽  
Control Analysis ◽  
Pharmaceutical Dosage Forms ◽  
Rp Hplc ◽  
Ich Guidelines ◽  
Anti Platelet Drug ◽  
Sarpogrelate Hydrochloride ◽  
The Mean ◽  
Development And Validation

A simple and precise RP-HPLC method has been developed and validated for the estimation of sarpogrelate hydrochloride, an anti-platelet drug in bulk and pharmaceutical dosage forms. Sarpogrelate is an antagonist at 5HT2A and 5HT2B receptors which blocks serotonin induced platelet aggregation and has application in the treatment of diseases including diabetes mellitus, Raynaud’s disease, angina pectoris and atherosclerosis. Chromatography was carried out on a Phenomenex C18 (250 x 4.6mm, 5μm) column with a mobile phase of 10mM ammonium acetate and acetonitrile (45:55% v/v). The flow rate was 1.2mL/min. The detection wavelength was carried out at 220nm. The retention time is 3.356 minutes for sarpogrelate hydrochloride. The linearity was found in the range of 10-50 μg/ml (R = 0.999) and % RSD is less than 2%. The mean recoveries obtained for sarpogrelate hydrochloride were in the range of 98.73-100.67%. The method is validated as per ICH guidelines and can be applied for the estimation of percentage purity in Sarpogrelate hydrochloride for quality control analysis in bulk and its dosage forms.

Henoch-Schoenlein Purpura

1992 ◽  
Vol 13 (4) ◽  
pp. 130-137
Author(s):  
Shelley Lanzkowsky ◽  
Leora Lanzkowsky ◽  
Philip Lanzkowsky
Keyword(s):  
Abdominal Pain ◽  
Leukocytoclastic Vasculitis ◽  
Renal Involvement ◽  
Gastrointestinal Symptoms ◽  
Female Ratio ◽  
Course Of Illness ◽  
Colicky Abdominal Pain ◽  
Allergic Vasculitis ◽  
Male To Female ◽  
First Descriptions

The distinctive syndrome of Henoch-Schoenlein purpura (HSP) was first described by Heberden before 1800, and in 1808 English physician Robert Willan described a patient who had swollen, painful joints and a rash. The syndrome owes its name to two German physicians. In 1837, Johan Schoenlein described several cases of purpura associated with arthritis, which he termed "peliosis rheumatica." In 1868, Edouard Henoch pointed out that the term "peliosis rheumatica" was inappropriate and restrictive because patients who had urticarial purpura and acute arthritis also manifested gastrointestinal symptoms, such as vomiting, colicky abdominal pain, and melena. He described four children who had purpura, colicky abdominal pain, gastrointestinal hemorrhage, and joint pain as well as renal involvement.1 Since these first descriptions, HSP also has been referred to as anaphylactoid, allergic, or rheumatoid purpura; leukocytoclastic vasculitis; and allergic vasculitis.1,2 Epidemiology Seventy-five percent of all cases of HSP occur in children between 2 and 11 years of age, with younger children rarely affected. Children younger than 2 y experience a milder course of illness, with less frequent renal and gastrointestinal manifestations.3 HSP is exceedingly rare in adults, among whom other causes of vasculitis should be considered more likely. The incidence of HSP is greater in males, with a male-to-female ratio of 1.5 to 2.0:1.

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