scholarly journals Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (11) ◽  
pp. 2329-2336 ◽  
Author(s):  
Falastin Salami ◽  
Hye-Seung Lee ◽  
Eva Freyhult ◽  
Helena Elding Larsson ◽  
Åke Lernmark ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Cell ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Islet Autoantibodies ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Increased Risk

scholarly journals Effects of the tiletamine/zolazepam-xylazine-tramadol combination on plasma oxidative status and haematological indicators in miniature pigs

2014 ◽  
Vol 83 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Sheng Jiang ◽  
Hong-Gang Fan ◽  
De-Zhang Lu ◽  
Jin-Long Hou ◽  
Xu-Dong Song ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Blood Cell ◽  
Cell Volume ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Packed Cell Volume ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Baseline Values

Oxidative stress in the body occurs when the production of free radicals overwhelms the antioxidant defence systems. The aim of this study was to examine the effects of a tiletamine/zolazepam-xylazine-tramadol combination on the antioxidant status, lipoperoxidase and blood cell indicators in eight miniature pigs. Baseline measures were recorded prior to anaesthesia, then the animals were anaesthetized with the combination of tiletamine/zolazepam (3.5 mg/kg), xylazine (1.32 mg/kg), and tramadol (1.8 mg/kg). Blood samples were collected from the anterior vena cava at 15, 30, 60, 90, 120 min, 24 h, and 72 h after anaesthesia. Plasma malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase concentrations were measured by colorimetry, and red blood cell counts, white blood cell counts, haemoglobin and packed cell volume were determined using an automated cell counter. The results showed that the concentration of malondialdehyde increased significantly at 30 and 60 min after the injection (P< 0.05), whereas glutathione peroxidase and catalase activity increased slightly (P> 0.05) then returned to baseline values after 90 min (P> 0.05). Superoxide dismutase activity increased significantly (P< 0.05) at 30 and 60 min, and then gradually decreased to baseline values after 90 min. Changes in red blood cell counts, haemoglobin and packed cell volume were not significant, while white blood cell count decreased significantly (P< 0.05) at 30 and 60 min. Our study is the first to demonstrate that tiletamine/zolazepam-xylazine-tramadol provide antioxidant effects, which may be proposed for alleviating the stress of examination and research at veterinary clinics or long-distance transportation.

scholarly journals Changes in Some Haematological Parameters of Pubertal Yankasa Rams ‎Fed Graded Levels of Dietary Protein Using Cotton Seed and Palm Kernel ‎Cake

2020 ◽  
Vol 17 (1) ◽  
pp. 7-11
Author(s):  
Taiwo Kamardeen Bello ◽  
Balkisu Banke Oyelowo ◽  
Raheela Hassan ◽  
Brenda Oke ◽  
Sheriff Yusuf Idris ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Dietary Protein ◽  
Total Protein ◽  
Packed Cell Volume ◽  
Crude Protein ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

The effects of graded levels of dietary protein on some haematological parameters in pubertal Yankasa rams were studied. They were randomly divided into three treatment groups (A, B and C). Groups A, B and C received 10%, 15% and 20% crude protein respectively. All rams were fed a basal diet of hay (Digitaria spp) ad-libitum and given a supplement ration of concentrate mixture at 2% body weight/day. Blood was collected once weekly via jugular venepuncture into heparinised test-tubes, and transported to the laboratory for determination of red blood cell counts, packed cell volume, white blood cell counts and total protein for twelve weeks. The overall mean red blood cell values obtained were 4.2 ± 0.1 ×106 µl, 5.2 ± 0.1 106 µl and 5.06 ± 0.1 ×106 µl, for groups A, B and C respectively. The difference between values obtained for groups B and C were not significantly different (P > 0.05). Mean packed cell volumes obtained in this study revealed that rams fed 15% crude protein had significantly (P < 0.05) higher values (31.3 ± 0.9%) than those fed 10% (25.9± 0.7%) but similar to those fed 20% (30.33 ± 0.56%) crude protein. There were no significant (P > 0.05) differences in mean white blood cell counts and total protein concentrations between all groups of animals fed 10% CP. Feeding rams diets containing 15 % CP (cotton seed cake and palm kernel cake) gave better values in terms of packed cell volume and red blood cell counts, than feeding diets containing 10% and 20% C.P. While graded levels of dietary protein was shown to affect packed cell volume and total protein concentration, it had no significant effect on red blood cell and white blood cell counts.  

scholarly journals Longitudinal multi-omics transition associated with fatality in critically ill COVID-19 patients

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Chaoyang Sun ◽  
Yuzhe Sun ◽  
Ping Wu ◽  
Wencheng Ding ◽  
Shiyou Wang ◽  
...  
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
Clinical Data ◽  
Red Blood Cell ◽  
Serum Samples ◽  
Risk Of Death ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Increased Risk ◽  
Independent Cohort

Abstract Purpose Critically ill COVID-19 patients have significantly increased risk of death. Although several circulating biomarkers are thought to be related to COVID-19 severity, few studies have focused on the characteristics of critically ill patients with different outcomes. The objective of this study was to perform a longitudinal investigation of the potential mechanisms affecting the prognosis of critically ill COVID-19 patients. Methods In addition to clinical data, 113 whole blood samples and 85 serum samples were collected from 33 severe and critical COVID-19 patients without selected comorbidities. Multi-omics analysis was then performed using longitudinal samples. Results Obvious transcriptional transitions were more frequent in critical survivors than in critical non-survivors, indicating that phase transition may be related to survival. Based on analysis of differentially expressed genes during transition, the erythrocyte differentiation pathway was significantly enriched. Furthermore, clinical data indicated that red blood cell counts showed greater fluctuation in survivors than in non-survivors. Moreover, declining red blood cell counts and hemoglobin levels were validated as prognostic markers of poor outcome in an independent cohort of 114 critical COVID-19 patients. Protein–metabolite–lipid network analysis indicated that tryptophan metabolism and melatonin may contribute to molecular transitions in critical COVID-19 patients with different outcomes. Conclusions This study systematically and comprehensively depicted the longitudinal hallmarks of critical COVID-19 patients and indicated that multi-omics transition may impact the prognosis. Take home message Frequent transcriptional phase transitions may contribute to outcome in critically ill COVID-19 patients. Furthermore, fluctuation in red blood cell and hemoglobin levels may relate to poor prognosis. The biological function of melatonin was suppressed in COVID-19 non-survivors, which may provide a potential theoretical basis for clinical administration.

scholarly journals THE STUDY OF HAEMATOLOGICAL PARAMETERS IN THE NIGERIAN LOCAL CHICKEN

2021 ◽  
Vol 23 (1) ◽  
pp. 94-97
Author(s):  
F. U. C. MMEREOLE
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Sedimentation Rates ◽  
Coagulation Time ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Local Chicken ◽  
White Blood Cell Counts ◽  
Blood Characteristics

An investigation was conducted to study the haematological parameters of the Nigerian local chicken using a total of 100 local chickens out of which 30 were randomly selected for bleeding. The blood samples were subjected to laboratory analysis to identify their haemoglobin contents, fragility and sedimentation rates as well as red blood cell counts, white blood cell counts and coagulation time. The results indicated that haemoglobin content ranged from 63.82 - 78.,43% with a mean of 70,43%, fragility and sedimentation rates ranged from 0.40 - 0.85% osmotic equivalent, coagulation time from 3.82 -6.25 minutes with a mean of 4.61 minutes, the red blood cell counts from 1.93 - 2.96 (x10°/ul) with a mean of 2.5 (x10°/ul) and white blood cell counts from 962 - 1,868 cells/ul with a mean of 1,216 cells/ul. It is believed that the establishment of the normal blood characteristics of the local chicken as done in this study, can be of immense aid in detecting abnormalities in the blood characteristics which can be used in diagnosing certain blood related diseases.

An Alternative Elastase-mediated Degradation of Fibrinogen and Fibrin Observed in a Patient with Herpes Simplex Encephalitis and Pneumonia

1996 ◽  
Vol 76 (02) ◽  
pp. 184-186 ◽  
Author(s):  
Kenji lijima ◽  
Fumiyo Murakami ◽  
Yasushi Horie ◽  
Katsumi Nakamura ◽  
Shiro Ikawa ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Blood Cell ◽  
White Blood Cell ◽  
Herpes Simplex Encephalitis ◽  
Pmn Elastase ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Sds Page ◽  
White Blood Cell Counts ◽  
Pmn Élastase

SummaryA 74-year-old female developed pneumonia following herpes simplex encephalitis. Her white blood cell counts reached 28,400/μl, about 90% of which consisted of granulocytes. The polymorphonuclear (PMN) elastase/α1-arantitrypsin complex levels increased and reached the maximum of 5,019 ng/ml, indicating the release of a large amount of elastase derived from the granulocytes. The mechanism of PMN elastase release was most likely to be granulocyte destruction associated with phagocytosis. The cleavage of fibrinogen and fibrin by PMN elastase, independent of plasmin, was indicated by the presence of the fragments in immunoprecipitated plasma from the patient corresponding to elastase-induced FDP D and DD fragments and the absence of fragments corresponding to plasmin-induced FDP D and DD fragments on SDS-PAGE. These findings suggested that the large amount of PMN elastase released from the excessive numbers of granulocytes in this patient with herpes simplex encephalitis and pneumonia, induced the cleavage of fibrinogen and fibrin without the participation of plasmin.

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