scholarly journals Longitudinal multi-omics transition associated with fatality in critically ill COVID-19 patients

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Chaoyang Sun ◽  
Yuzhe Sun ◽  
Ping Wu ◽  
Wencheng Ding ◽  
Shiyou Wang ◽  
...  
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
Clinical Data ◽  
Red Blood Cell ◽  
Serum Samples ◽  
Risk Of Death ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Increased Risk ◽  
Independent Cohort

Abstract Purpose Critically ill COVID-19 patients have significantly increased risk of death. Although several circulating biomarkers are thought to be related to COVID-19 severity, few studies have focused on the characteristics of critically ill patients with different outcomes. The objective of this study was to perform a longitudinal investigation of the potential mechanisms affecting the prognosis of critically ill COVID-19 patients. Methods In addition to clinical data, 113 whole blood samples and 85 serum samples were collected from 33 severe and critical COVID-19 patients without selected comorbidities. Multi-omics analysis was then performed using longitudinal samples. Results Obvious transcriptional transitions were more frequent in critical survivors than in critical non-survivors, indicating that phase transition may be related to survival. Based on analysis of differentially expressed genes during transition, the erythrocyte differentiation pathway was significantly enriched. Furthermore, clinical data indicated that red blood cell counts showed greater fluctuation in survivors than in non-survivors. Moreover, declining red blood cell counts and hemoglobin levels were validated as prognostic markers of poor outcome in an independent cohort of 114 critical COVID-19 patients. Protein–metabolite–lipid network analysis indicated that tryptophan metabolism and melatonin may contribute to molecular transitions in critical COVID-19 patients with different outcomes. Conclusions This study systematically and comprehensively depicted the longitudinal hallmarks of critical COVID-19 patients and indicated that multi-omics transition may impact the prognosis. Take home message Frequent transcriptional phase transitions may contribute to outcome in critically ill COVID-19 patients. Furthermore, fluctuation in red blood cell and hemoglobin levels may relate to poor prognosis. The biological function of melatonin was suppressed in COVID-19 non-survivors, which may provide a potential theoretical basis for clinical administration.

scholarly journals Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (11) ◽  
pp. 2329-2336 ◽  
Author(s):  
Falastin Salami ◽  
Hye-Seung Lee ◽  
Eva Freyhult ◽  
Helena Elding Larsson ◽  
Åke Lernmark ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Cell ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Islet Autoantibodies ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Increased Risk

scholarly journals Changes of Hematocrit, Hemoglobin, Serum Protein Levels and Red Blood Cell Counts Before and After Stroke

1976 ◽  
Vol 13 (4) ◽  
pp. 207-214
Author(s):  
Hiroshi Yamanouchi ◽  
Hideo Tohgi ◽  
Masakuni Kameyama ◽  
Mototaka Murakami ◽  
Tamotsu Matsuda
Keyword(s):  
Blood Cell ◽  
Serum Protein ◽  
Red Blood Cell ◽  
Protein Levels ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Before And After

scholarly journals Changes in Serum Lipids from Egg Consumption Are Associated with Clinical Erythrocyte Indices (P08-093-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Julia Greco ◽  
Allison Sloan ◽  
Christa Palancia Esposito ◽  
Aaron Van Dyke ◽  
Catherine Andersen
Keyword(s):  
Blood Cell ◽  
Total Cholesterol ◽  
Red Blood Cell ◽  
Serum Lipids ◽  
Hdl Cholesterol ◽  
Distribution Width ◽  
Erythrocyte Indices ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Induced Changes

Abstract Objectives Serum lipids may influence the lifespan of erythrocytes, and have been associated with clinical erythrocyte indices at the population level. Consumption of whole eggs vs. egg whites exerts varying effects on serum lipids and lipoprotein profiles; therefore, we investigated whether egg-induced changes in serum lipids correspond to changes in clinical erythrocyte markers. Methods Young, healthy men and women (18–35y, BMI < 30 kg/m2, n = 11) were recruited to participate in an ongoing intervention trial. All subjects followed an egg-free diet for 4 weeks, then were randomized to consume either 3 whole eggs or 3 egg whites per day for 4 weeks. Fasting serum lipids, complete blood cell counts, and dietary intake analysis was performed at the end of each study period. Results Average serum lipids and erythrocyte indices were within normal ranges at the end of each diet period. Changes in total cholesterol following the whole egg (+4.8%) and egg white (0.4%) diet period were not significant as compared to the egg-free diet period. Similarly, clinical erythrocyte markers were not significantly altered by daily consumption of whole eggs or egg whites. However, changes in total cholesterol and LDL-cholesterol between diet periods were positively correlated with changes in total red blood cell counts and hemoglobin. Total cholesterol was additionally correlated with hematocrit levels, and negatively associated with red cell distribution width. Total red blood cell counts and hemoglobin were further correlated with changes in the total cholesterol to HDL-cholesterol ratios, but not HDL-cholesterol alone. Conclusions Our findings indicate that egg-induced changes in serum lipids are associated with clinical erythrocyte indices, and that total cholesterol levels and dyslipidemia may be more significant determinants of erythrocyte profiles. Funding Sources This study was funded by an Agriculture and Food Research Initiative Grant from the USDA National Institute of Food and Agriculture.

Hematology distinguishes coastal and offshore forms of dolphins (Tursiops)

1983 ◽  
Vol 61 (4) ◽  
pp. 930-933 ◽  
Author(s):  
Deborah A. Duffield ◽  
Sam H. Ridgway ◽  
Lanny H. Cornell
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Tursiops Truncatus ◽  
Genetic Basis ◽  
Bottlenose Dolphins ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Cell Volumes

Bottlenose dolphins, Tursiops truncatus, can be separated into coastal and offshore ecotypes based upon hemoglobin levels, packed cell volumes, and red blood cell counts, the offshore form having higher values for all three measures. Captive-bred crosses between coastal and offshore types produce animals with intermediate hematologic profiles suggesting a significant genetic basis for these differences.

Are elevated fetal nucleated red blood cell counts an indirect reflection of enhanced erythropoietin activity?

2004 ◽  
Vol 190 (5) ◽  
pp. 1473-1475 ◽  
Author(s):  
Asaf Ferber ◽  
Zhanna Fridel ◽  
Alina Weissmann-Brenner ◽  
Victoria K Minior ◽  
Michael Y Divon
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Nucleated Red Blood Cell

The Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Women

2009 ◽  
Vol 31 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Hugo W. Huisman ◽  
Aletta E. Schutte ◽  
Johannes M. van Rooyen ◽  
Rudolph Schutte ◽  
Leoné Malan ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Endothelin 1 ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Caucasian Women
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