Prediction of Adverse Pregnancy Outcomes among Women with Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1630-P
Author(s):  
TINA COSTACOU ◽  
DEBRA RUBINSTEIN ◽  
TREVOR J. ORCHARD
Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1376-P
Author(s):  
SIHUI LUO ◽  
PING LING ◽  
YU DING ◽  
XUEYING ZHENG ◽  
DAIZHI YANG ◽  
...  

2018 ◽  
Vol 6 (4) ◽  
pp. 111 ◽  
Author(s):  
Flavia Sacerdoti ◽  
María Scalise ◽  
Juliana Burdet ◽  
María Amaral ◽  
Ana Franchi ◽  
...  

Gastrointestinal infection with Shiga toxin-producing Escherichia coli (STEC) causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS), characterized by hemolytic anemia, thrombocytopenia and acute renal failure. The main virulence factor of STEC is Shiga toxin (Stx), which is responsible for HUS development. STEC can produce Stx type 1 and/or 2 (Stx1, Stx2) and their variants, Stx2 being more frequently associated with severe cases of HUS. This pathology occurs in 5–15% of cases with STEC infection when Stx gain access to the bloodstream and causes damage in the target organs such as the kidney and brain. STEC infections affect mainly young children, although the large HUS outbreak with a new Stx2-producing STEC O104:H4 in Europe in 2011 involved more adults than children, and women were over-represented. Maternal infections during pregnancy are associated with adverse pregnancy outcomes. Studies in rats showed that Stx2 binds to the utero-placental unit and causes adverse pregnancy outcomes. In this article, we provide a brief overview of Stx2 action on placental tissues and discuss whether they might cause pregnancy loss or preterm birth.


2006 ◽  
Vol 195 (6) ◽  
pp. S120
Author(s):  
Trishna Goswami ◽  
Madhurima Uppalapati ◽  
Holly Masel ◽  
Nisha Vyas ◽  
Helain Landy ◽  
...  

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