473-P: HDAC Inhibition Augments TGF-ß-Induced JNK Activation, CTGF Expression, and NF-E2 Degradation Promoting Profibrotic Signaling in Renal Proximal Tubules

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 473-P
Author(s):  
JIA LI ◽  
MADHAVI JAGDISH RANE ◽  
LU CAI ◽  
YI TAN
Keyword(s):  
Proximal Tubules ◽  
Hdac Inhibition ◽  
Renal Proximal Tubules ◽  
Jnk Activation

Expression of Cyt-c-Mediated Mitochondrial Apoptosis-Related Proteins in Rat Renal Proximal Tubules during Development

Nephron ◽  
2016 ◽  
Vol 135 (1) ◽  
pp. 77-86 ◽  
Author(s):  
Xiao-Feng Song ◽  
He Tian ◽  
Ping Zhang ◽  
Zhen-Xing Zhang
Keyword(s):  
Proximal Tubules ◽  
Mitochondrial Apoptosis ◽  
Renal Proximal Tubules ◽  
Cyt C ◽  
Related Proteins

scholarly journals SUN-140 EFFECTS OF PARATHYROID HORMONE ON GLUCOSE METABOLISM IN RENAL PROXIMAL TUBULES

2019 ◽  
Vol 4 (7) ◽  
pp. S216
Author(s):  
H. Tsukada ◽  
M. Nakamura ◽  
N. Satoh ◽  
T. Mizuno ◽  
Y. Sato ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Glucose Metabolism ◽  
Proximal Tubules ◽  
Renal Proximal Tubules

Spontaneous release of glycosylphosphatidylinositol (GPI)-anchored renal dipeptidase from porcine renal proximal tubules

2002 ◽  
Vol 25 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Sung Wook Park ◽  
Bok Yun Kang ◽  
Hyun Joong Yoon ◽  
Eun Mi Park ◽  
Kyong Choi ◽  
...  
Keyword(s):  
Proximal Tubules ◽  
Spontaneous Release ◽  
Renal Proximal Tubules

scholarly journals Predominance of ACE2‐Dependent Metabolism of Angiotensin II But Not Angiotensin I In Sheep Renal Proximal Tubules and Urine

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Hossam A Shaltout ◽  
Brian Westwood ◽  
David Averill ◽  
Jorge Figueroa ◽  
Carlos Ferrario ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Proximal Tubules ◽  
Angiotensin I ◽  
Renal Proximal Tubules

scholarly journals Renal Angiotensinogen in Nonhuman Primates is Predominantly Liver-Derived

2021 ◽  
Author(s):  
Masayoshi Kukida ◽  
Lei Cai ◽  
Dien Ye ◽  
Hisashi Sawada ◽  
Yuriko Katsumata ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Antisense Oligonucleotides ◽  
Nonhuman Primates ◽  
Primary Source ◽  
Renin Angiotensin System ◽  
Proximal Tubules ◽  
Specific Inhibition ◽  
Angiotensin System ◽  
Renal Proximal Tubules ◽  
Cynomolgus Monkeys

AGT (Angiotensinogen) is the unique substrate of the renin-angiotensin system. Liver is the primary source of circulating AGT. The present study determined whether hepatocyte-derived AGT regulates renal AGT accumulation by injecting ASO (antisense oligonucleotides) targeting hepatocyte-derived AGT (GalNAc AGT ASO) into female cynomolgus monkeys. Hepatocyte-specific inhibition of AGT led to profound reductions of plasma AGT concentrations. AGT protein in S1 and S2 of renal proximal tubules was greatly diminished by GalNAc AGT ASO. Given the similarity between nonhuman primates and human, our findings support the notion that renal AGT is predominantly derived from liver, and liver regulates renal angiotensin II production in humans.

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