Effect of amphotericin B‐deoxycholate (Fungizone) on the mitochondria of Wistar rats' renal proximal tubules cells

2021 ◽  
Author(s):  
Shehab Ahmed Alenazi ◽  
Ekramy Elmorsy ◽  
Ayat Al‐Ghafari ◽  
Amr El‐Husseini
Keyword(s):  
Amphotericin B ◽  
Wistar Rats ◽  
Proximal Tubules ◽  
Renal Proximal Tubules ◽  
Amphotericin B Deoxycholate

scholarly journals The Calcium Sensing Receptor Activation by Neomycin Decreases the Bicarbonate Flux in Renal Proximal Tubules of Wistar Rats

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Priscilla M Santos ◽  
Ricardo Fernandez ◽  
Gerhard Malnic ◽  
Thaissa Pessoa
Keyword(s):  
Wistar Rats ◽  
Receptor Activation ◽  
Proximal Tubules ◽  
Calcium Sensing Receptor ◽  
Renal Proximal Tubules ◽  
Calcium Sensing

Expression of Cyt-c-Mediated Mitochondrial Apoptosis-Related Proteins in Rat Renal Proximal Tubules during Development

Nephron ◽  
2016 ◽  
Vol 135 (1) ◽  
pp. 77-86 ◽  
Author(s):  
Xiao-Feng Song ◽  
He Tian ◽  
Ping Zhang ◽  
Zhen-Xing Zhang
Keyword(s):  
Proximal Tubules ◽  
Mitochondrial Apoptosis ◽  
Renal Proximal Tubules ◽  
Cyt C ◽  
Related Proteins

scholarly journals SUN-140 EFFECTS OF PARATHYROID HORMONE ON GLUCOSE METABOLISM IN RENAL PROXIMAL TUBULES

2019 ◽  
Vol 4 (7) ◽  
pp. S216
Author(s):  
H. Tsukada ◽  
M. Nakamura ◽  
N. Satoh ◽  
T. Mizuno ◽  
Y. Sato ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Glucose Metabolism ◽  
Proximal Tubules ◽  
Renal Proximal Tubules

scholarly journals Comparative Drug Disposition, Urinary Pharmacokinetics, and Renal Effects of Multilamellar Liposomal Nystatin and Amphotericin B Deoxycholate in Rabbits

2003 ◽  
Vol 47 (12) ◽  
pp. 3917-3925 ◽  
Author(s):  
Andreas H. Groll ◽  
Diana Mickiene ◽  
Vidmantas Petraitis ◽  
Ruta Petraitiene ◽  
Raul M. Alfaro ◽  
...  
Keyword(s):  
Total Dose ◽  
Amphotericin B ◽  
Drug Disposition ◽  
Fungal Infections ◽  
Standard Dose ◽  
Concentration Data ◽  
Drug Concentrations ◽  
Amphotericin B Deoxycholate ◽  
Dose Dependent Decrease ◽  
Dose Dependent

ABSTRACT The comparative drug dispositions, urinary pharmacokinetics, and effects on renal function of multilamellar liposomal nystatin (LNYS; Nyotran) and amphotericin B deoxycholate (DAMB; Fungizone) were studied in rabbits. Drug concentrations were determined by high-performance liquid chromatography as total concentrations of LNYS and DAMB. In comparison to a standard dose of 1 mg of DAMB/kg of body weight, therapeutic dosages of LNYS, i.e., 2, 4, and 6 mg/kg, resulted in escalating maximum concentrations (C max) (17 to 56μ g/ml for LNYS versus 3.36 μg/ml for DAMB; P< 0.001) and values for the area under the concentration-time curve from 0 to 24 h (AUC0-24) (17 to 77μ g · h/ml for LNYS versus 12μ g · h/ml for DAMB; P < 0.001) in plasma but a significantly faster total clearance from plasma (0.117 to 0.080 liter/h/kg for LNYS versus 0.055 liter/h/kg for DAMB; P = 0.013) and a ≤8-fold-smaller volume of distribution at steady state (P = 0.002). Urinary drug concentration data revealed a ≥10-fold-higher C max (16 to 10 μg/ml for LNYS versus 0.96μ g/ml for DAMB; P = 0.015) and a 4- to 7-fold-greater AUC0-24 (63 to 35μ g · h/ml for LNYS versus 8.9μ g · h/ml for DAMB; P = 0.015) following the administration of LNYS, with a dose-dependent decrease in the dose-normalized AUC0-24 in urine (P= 0.001) and a trend toward a dose-dependent decrease in renal clearance. Except for the kidneys, the mean concentrations of LNYS in liver, spleen, and lung 24 h after dosing were severalfold lower than those after administration of DAMB (P,<0.002 to <0.001). Less than 1% each of the total dose of LNYS was recovered from the kidneys, liver, spleen, and lungs; in contrast, a quarter of the total dose was recovered from the livers of DAMB-treated animals. LNYS had dose-dependent effects on glomerular filtration and distal, but not proximal, renal tubular function which did not exceed those of DAMB at the highest investigated dosage of 6 mg/kg. The results of this experimental study demonstrate fundamental differences in the dispositions of LNYS and DAMB. Based on its enhanced urinary exposure, LNYS may offer a therapeutic advantage in systemic fungal infections involving the upper and lower urinary tracts that require therapy with antifungal polyenes.

A novel low-affinity strychnine binding site on renal proximal tubules: Role in toxic cell death

Life Sciences ◽  
1993 ◽  
Vol 53 (15) ◽  
pp. 1203-1209 ◽  
Author(s):  
Gary W. Miller ◽  
Rick G. Schnellmann
Keyword(s):  
Cell Death ◽  
Binding Site ◽  
Proximal Tubules ◽  
Renal Proximal Tubules

scholarly journals Life‐Threatening Adverse Event After Amphotericin B Lipid Complex Treatment in a Patient Treated Previously with Amphotericin B Deoxycholate

1998 ◽  
Vol 26 (4) ◽  
pp. 1016-1016 ◽  
Author(s):  
J. Garnacho‐Montero ◽  
C. Ortiz‐Leyba ◽  
J. L. García Garmendia ◽  
F. J. Jiménez Jiménez
Keyword(s):  
Adverse Event ◽  
Amphotericin B ◽  
Complex Treatment ◽  
Lipid Complex ◽  
Amphotericin B Deoxycholate ◽  
Life Threatening ◽  
Amphotericin B Lipid Complex

Fluorescence of Amphotericin B-Deoxycholate (Fungizone) Monomers and Aggregates and the Effect of Heat-Treatment

Langmuir ◽  
2007 ◽  
Vol 23 (17) ◽  
pp. 8718-8725 ◽  
Author(s):  
Robin Stoodley ◽  
Kishor M. Wasan ◽  
Dan Bizzotto
Keyword(s):  
Heat Treatment ◽  
Amphotericin B ◽  
Amphotericin B Deoxycholate
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