Associations of Anti-GAD Antibodies with Islet Cell Antibodies and Insulin Autoantibodies in First-Degree Relatives of Type I Diabetic Patients

Diabetes ◽  
1994 ◽  
Vol 43 (1) ◽  
pp. 154-160 ◽  
Author(s):  
U. Roll ◽  
M. R. Christie ◽  
E. Standl ◽  
A.-G. Ziegler
Keyword(s):  
Islet Cell ◽  
Islet Cell Antibodies ◽  
Insulin Autoantibodies ◽  
Diabetic Patients ◽  
Type I ◽  
Gad Antibodies ◽  
First Degree Relatives

A Tumor Necrosis Factor  -Gene Polymorphism Associated With Islet Cell Antibodies in Newly Diagnosed Type I Diabetic Patients

Diabetes Care ◽  
1994 ◽  
Vol 17 (8) ◽  
pp. 944-945
Author(s):  
J. Vendrell ◽  
G. Ercilla ◽  
C. Gutierrez ◽  
R. Gomis ◽  
A. Goday ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Islet Cell ◽  
Tumor Necrosis ◽  
Islet Cell Antibodies ◽  
Diabetic Patients ◽  
Type I ◽  
Newly Diagnosed ◽  
Factor Gene ◽  
Tumor Necrosis Factor Gene ◽  
Necrosis Factor

Anti-goat immunoglobulin antibodies in diabetic children at diagnosis and follow-up: comparison with islet cell antibodies and other autoantibodies

1989 ◽  
Vol 120 (3) ◽  
pp. 326-330 ◽  
Author(s):  
U. Di Mario ◽  
L. Crisa ◽  
E. Anastasi ◽  
G. Contreas ◽  
D. Andreani ◽  
...  
Keyword(s):  
Islet Cell ◽  
Solid Phase ◽  
Type I Diabetes ◽  
Islet Cell Antibodies ◽  
Normal Subjects ◽  
Islet Cell Antibody ◽  
Diabetic Patients ◽  
Type I ◽  
Recent Onset

Abstract. The presence of antibodies reacting with human as well as animal immunoglobulins in sera from recent onset Type I diabetic patients has been recently demonstrated by some of our group. In the present study, the occurrence of these antibodies has been evaluated in sera from 19 Type I diabetic patients, at diagnosis and at follow-up within three years, and from 26 normal subjects, and has also been compared with the presence of islet cell antibodies and other organ-specific autoantibodies. A solid-phase radioimmunoassay has been used: serum was incubated in goat immunoglobulin-coated wells and the binding of 125-I-anti-human immunoglobulin antibodies was evaluated. Anti-goat immunoglobulin antibodies were above the 90th percentile of normal values in all diabetic patients at diagnosis (median, interquartile range, in μg 125I-antibody bound/1 serum: 83, 77.5–88, versus 51.5, 44.5–62 in normal subjects, P < 0.001) and significantly declined with time after diagnosis (P < 0.001). Islet cell antibodies were present in 79% of patients at diagnosis, whereas at least one other auto-antibody was found in 21% of patients. In the follow-up study the decline in anti-goat immunoglobulin antibody levels was different from that of islet cell antibody positivity. A circulating immunoglobulin reacting with other immunoglobulins is thus present in the early stages of Type I diabetes and may well play a part in the complex immunopathogenetic interactions.

Proinsulin autoantibodies: Association with type I diabetes but not with islet cell antibodies, insulin autoantibodies or HLA-DR type

1990 ◽  
Vol 3 (5) ◽  
pp. 573-577 ◽  
Author(s):  
Bernd Kuglin ◽  
Babette Halder ◽  
Jörg Bertrams ◽  
Dieter Grüneklee ◽  
F. Arnold Gries ◽  
...  
Keyword(s):  
Islet Cell ◽  
Type I Diabetes ◽  
Islet Cell Antibodies ◽  
Insulin Autoantibodies ◽  
Type I ◽  
Hla Dr

Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes

Diabetes ◽  
1992 ◽  
Vol 41 (3) ◽  
pp. 347-353 ◽  
Author(s):  
R. Gianani ◽  
A. Pugliese ◽  
S. Bonner-Weir ◽  
A. J. Shiffrin ◽  
J. S. Soeldner ◽  
...  
Keyword(s):  
Islet Cell ◽  
Type I Diabetes ◽  
Islet Cell Antibodies ◽  
Significant Heterogeneity ◽  
Type I
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