Induced hyperglycemia alters antithrombin III activity but not its plasma concentration in healthy normal subjects

Abstract Protein C, a newly identified inhibitor of blood coagulation, was measured immunologically in 58 patients with untreated acute leukemias and compared with that of normal subjects. On the average, slightly lower values were found. However, the 17 patients with overt laboratory pictures of decompensated disseminated intravascular coagulation (DIC), including 11 cases with acute promyelocytic leukemia, had protein C concentrations no lower than those of the remaining 41 patients without DIC. Antithrombin III activity and antigen were normal and, like protein C, not lowered in DIC. The concentrations of both proteins were closely correlated with changes in the indexes for liver synthetic function. A subgroup of 13 patients with hyperleukocytic leukemias had lower protein C and antithrombin III, in line with the more compromised synthetic function of their livers. Our findings indicate that liver impairment rather than DIC is the main cause of the changes in the two naturally occurring inhibitors of blood coagulation.

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Fibrinogen, Factor VIII Related Antigen, Antithrombin III and α2-Antiplasmin in Peripheral Arterial Disease

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661187 ◽

1984 ◽

Vol 52 (03) ◽

pp. 240-242 ◽

Cited By ~ 16

Author(s):

M Christe ◽

A Delley ◽

G A Marbet ◽

L Biland ◽

F Duckert

Keyword(s):

Myocardial Infarction ◽

Peripheral Arterial Disease ◽

Antithrombin Iii ◽

Normal Subjects ◽

Arterial Disease ◽

General Tendency ◽

Previous Myocardial Infarction ◽

Exercise Ecg ◽

Peripheral Arterial ◽

Antithrombin Iii Activity

SummaryIn 306 subjects, 217 without and 89 with peripheral arterial disease (PAD), VIIIR:Ag and α2-antiplasmin are significantly higher in PAD (p < 0.01). In the PAD negative group the ratio α2-antiplasmin/antithrombin III activity is significantly higher 1.11 ± 0.3 in the patients with an abnormal exercise ECG typical of coronary disease than in normal subjects 1.02 ± 0.2 (p < 0.05). In the PAD positive group antithrombin III concentration is higher in patients with a normal exercise ECG than in patients with abnormal exercise ECG (p < 0.05). The same is true for α2- antiplasmin but not for the antithrombin III activity. Fibrinogen and VIIIR:Ag are higher in patients with a previous myocardial infarction, however, the age is also significantly different as compared to the group without previous myocardial infarction. Disturbance of the cerebral arterial circulation is characterized by an elevation of VIIIR:Ag and of α2-antiplasmin as comapred to the values obtained in patients without this complication. There is a general tendency towards higher α2-antiplasmin values with the extension of the arterial disease.

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Liver dysfunction rather than intravascular coagulation as the main cause of low protein C and antithrombin III in acute leukemia

Blood ◽

10.1182/blood.v63.4.965.bloodjournal634965 ◽

1984 ◽

Vol 63 (4) ◽

pp. 965-969 ◽

Cited By ~ 1

Author(s):

F Rodeghiero ◽

PM Mannucci ◽

S Vigano ◽

T Barbui ◽

L Gugliotta ◽

...

Keyword(s):

Blood Coagulation ◽

Protein C ◽

Antithrombin Iii ◽

Normal Subjects ◽

Acute Leukemias ◽

Intravascular Coagulation ◽

Low Protein ◽

Lower Protein ◽

Synthetic Function ◽

Antithrombin Iii Activity

Protein C, a newly identified inhibitor of blood coagulation, was measured immunologically in 58 patients with untreated acute leukemias and compared with that of normal subjects. On the average, slightly lower values were found. However, the 17 patients with overt laboratory pictures of decompensated disseminated intravascular coagulation (DIC), including 11 cases with acute promyelocytic leukemia, had protein C concentrations no lower than those of the remaining 41 patients without DIC. Antithrombin III activity and antigen were normal and, like protein C, not lowered in DIC. The concentrations of both proteins were closely correlated with changes in the indexes for liver synthetic function. A subgroup of 13 patients with hyperleukocytic leukemias had lower protein C and antithrombin III, in line with the more compromised synthetic function of their livers. Our findings indicate that liver impairment rather than DIC is the main cause of the changes in the two naturally occurring inhibitors of blood coagulation.

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Antithrombin III Deficiency in Maturity Onset Diabetes Mellitus and Atherosclerosis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649168 ◽

1974 ◽

Vol 31 (02) ◽

pp. 339-345 ◽

Cited By ~ 12

Author(s):

R. N Banerjee ◽

A. L Sahni ◽

V Kumar ◽

M Arya

Keyword(s):

Diabetes Mellitus ◽

Antithrombin Iii ◽

Normal Subjects ◽

Close Correlation ◽

Maturity Onset Diabetes ◽

Onset Diabetes ◽

Antithrombin Iii Deficiency ◽

Antithrombin Iii Activity

SummaryAntithrombin III activity and thrombin times were assayed in maturity onset diabetics, atherosclerotic patients and normal subjects. There was a close correlation between the Antithrombin III activity and thrombin times in all three groups. Reductions in these measurements in diabetes mellitus and atherosclerosis, independent of thromboembolic phenomena, support the theory of Antithrombin III deficiency in these diseases.

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DNA Length Polymorphism Present in the Antithrombin III Promoter Region Does not Influence Plasma Antithrombin III Activity Levels

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650280 ◽

1996 ◽

Vol 75 (02) ◽

pp. 376-377 ◽

Cited By ~ 2

Author(s):

René W L M Niessen ◽

Roy J Lamping ◽

Augueste Sturk ◽

Marjolein Peters

Keyword(s):

Length Polymorphism ◽

Promoter Region ◽

Antithrombin Iii ◽

Activity Levels ◽

Antithrombin Iii Activity

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On the Natural Blood Coagulation Inhibitor System Investigations of Inhibitor Factors Based on Antithrombin Deficient Blood

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654884 ◽

1965 ◽

Vol 14 (03/04) ◽

pp. 473-489 ◽

Cited By ~ 13

Author(s):

O Egeberg

Keyword(s):

Normal Level ◽

Antithrombin Iii ◽

Strong Support ◽

Blood Protein ◽

Coagulation Inhibitor ◽

Inhibitor System ◽

Normal Human ◽

Partial Deficiency ◽

Antithrombin Iii Activity ◽

Prothrombinase Activity

SummaryNatural coagulation inhibitor factors were studied in sera, or in fractions of sera, from patients with congenital partial deficiency of antithrombin and from normal persons. In the patients’ sera the progressive antithrombin (antithrombin III) and heparin cofactor (antithrombin II) had both been measured around 50 per cent of normal level.No decreased activity could be demonstrated in the patients’ sera as to antiprothrombinase, the inhibitor against blood intrinsic prothrombinase activity.For anticonvertin, the inhibitor against the tissue convertin complex, the activity was found decreased to about the same level as that demonstrated for antithrombin III and II. The results lend strong support to the hypothesis that the activities measured as anticonvertin, antithrombin III and antithrombin II represent functions of the same blood protein, which on the other side appears to be distinct from antiprothrombinase. In accordance with this explanation, an antithrombin III concentrate had also antithrombin II and anticonvertin activity, and further, adsorption of a normal human serum with convertin appeared to specifically reduce its antithrombin III activity.The inhibitor against activated antihemophilic C factor (AHC’ = activated f. XI) was studied in sera adsorbed with BaS04 and celite. The inhibitor activity was found at normal level in the patients’ sera, consistent with the view that anti-AHC’ is distinct from antithrombin III, II and from anticonvertin. No acceleration of the anti-AHC’ activity could be demonstrated after addition to the inhibition mixture of weak solutions of heparin.The results are discussed.

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Lipoprotein Fractions and Antithrombin III Consumption During Clotting

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657176 ◽

1982 ◽

Vol 47 (03) ◽

pp. 236-238 ◽

Cited By ~ 4

Author(s):

J H Winter ◽

B Bennett ◽

F McTaggart ◽

A S Douglas

Keyword(s):

Blood Clotting ◽

Antithrombin Iii ◽

Initial Rate ◽

Density Lipoprotein ◽

Normal Subjects ◽

Lipid Levels ◽

Antithrombin Activity ◽

Artery Disease ◽

Immunological Assays ◽

Total Triglyceride

SummaryPlasma and serum antithrombin levels were measured in functional (initial rate measurement) and immunological assays together with serum lipid levels in normal subjects and patients with coronary artery disease. Specific antithrombin activity in plasma showed a negative correlation with triglyceride levels. The consumption of antithrombin activity during blood clotting was negatively correlated with both serum total triglyceride and heparin precipitable lipoprotein and positively correlated with serum high density lipoprotein cholesterol. Different blood lipoprotein fractions may influence the activity of the antithrombin III molecule.

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