Role of insulin and atrial natriuretic peptide in sodium retention in insulin-treated IDDM patients during isotonic volume expansion

Abstract Polyclonal antibodies raised in a rabbit against avian atrial natriuretic peptide (ANP) were shown to reduce circulating endogenous ANP levels in Pekin ducks by more than 90%, and were subsequently used to investigate the role of this peptide in volume expansion diuresis and natriuresis. Conscious birds, undergoing a steady-state diuresis and natriuresis maintained by an i.v. infusion of hypotonic saline at a rate of 0·7 ml/min, responded to ANP antiserum (anti-ANP) with an immediate 30% reduction in urine flow rate and sodium excretion which lasted for about 30 min. Plasma arginine vasotocin levels were not changed by anti-ANP whereas circulating angiotensin II concentrations increased immediately following the administration of anti-ANP. Serum from non-immunized normal rabbits produced no changes in the renal and plasma parameters monitored. The results show that the high circulating levels of endogenous ANP associated with volume expansion promote renal salt and fluid excretion and thus have a major physiological role in avian volume homeostasis. Journal of Endocrinology (1994) 140, 85–90

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Role of cardiac innervation in atrial natriuretic peptide secretion in transplanted heart recipients

AJP Renal Physiology ◽

10.1152/ajprenal.1993.265.1.f112 ◽

1993 ◽

Vol 265 (1) ◽

pp. F112-F118

Author(s):

B. Geny ◽

F. Piquard ◽

M. Follenius ◽

B. Mettauer ◽

A. Schaefer ◽

...

Keyword(s):

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Arginine Vasopressin ◽

Volume Expansion ◽

Biologically Active ◽

Control Group ◽

Cardiac Innervation ◽

Total Blood ◽

Atrial Natriuretic

To investigate whether cardiac innervation modulates atrial natriuretic peptide (ANP) secretion, we performed acute volume expansion on eight normal and eight matched (age, weight, and total blood volume) transplanted denervated heart patients (Htx), while monitoring fluid-regulating hormone, systemic blood pressure, and echocardiographic atrial area changes. At rest, plasma ANP and guanosine 3',5'-cyclic monophosphate (cGMP) were lower in control subjects than in Htx (45 +/- 16 vs. 103 +/- 35 pg/l and 0.9 +/- 0.3 vs. 3.5 +/- 1.4 pM, respectively; P < 0.001). Plasma active renin, aldosterone, and catecholamines did not differ significantly in the two populations, whereas arginine vasopressin and cortisol were higher in controls (P < 0.01 and P < 0.005). Although volume expansion (+15%) and atrial stretch were similar in the two groups, plasma ANP and cGMP increased significantly only in the Htx group (103 +/- 35 to 189 +/- 69 pg/l and 3.5 +/- 1.4 to 5.8 +/- 1.4 pM, respectively; P < 0.001). The decrease observed for the other hormones was not significant except for arginine vasopressin and cortisol (P < 0.05 and P < 0.001) in the control group. These results support the hypothesis of an inhibitory role of cardiac innervation in biologically active ANP secretion in humans, at rest and after acute volume expansion.

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Role of Atrial Natriuretic Peptide in the Response to Blood Volume Expansion in the Weanling Rat

Pediatric Research ◽

10.1203/00006450-199004000-00014 ◽

1990 ◽

Vol 27 (4) ◽

pp. 396-400 ◽

Cited By ~ 2

Author(s):

Robert L Chevalier ◽

Barbara Thornhill ◽

R Ariel Gomez ◽

Nancy V Ragsdale ◽

Michael J Peach ◽

...

Keyword(s):

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Blood Volume ◽

Volume Expansion ◽

Blood Volume Expansion ◽

Atrial Natriuretic

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Role of atrial natriuretic peptide in the natriuretic response to central volume expansion induced by head-out water immersion in sodium-retaining cirrhotic subjects

The American Journal of Medicine ◽

10.1016/0002-9343(88)90590-6 ◽

1988 ◽

Vol 85 (3) ◽

pp. 375-382 ◽

Cited By ~ 58

Author(s):

Karl L. Skorecki ◽

Wai Ming Leung ◽

Peter Campbell ◽

Leonard C. Warner ◽

Pui Y. Wong ◽

...

Keyword(s):

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Volume Expansion ◽

Water Immersion ◽

Central Volume ◽

Atrial Natriuretic

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Role of atrial natriuretic peptide in the pathogenesis of sodium retention in IDDM with and without glomerular hyperfiltration

Diabetes ◽

10.2337/diabetes.41.8.936 ◽

1992 ◽

Vol 41 (8) ◽

pp. 936-945 ◽

Cited By ~ 6

Author(s):

P. Fioretto ◽

M. Sambataro ◽

M. R. Cipollina ◽

C. Giorato ◽

A. Carraro ◽

...

Keyword(s):

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Glomerular Hyperfiltration ◽

Sodium Retention ◽

Atrial Natriuretic

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Role of atrial appendages in modulating stimulated plasma atrial natriuretic peptide levels in conscious rats

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1990.259.5.r1017 ◽

1990 ◽

Vol 259 (5) ◽

pp. R1017-R1024

Author(s):

A. Hoffman ◽

E. Grossman ◽

H. R. Keiser

Keyword(s):

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Plasma Levels ◽

Sodium Excretion ◽

Volume Expansion ◽

Vena Cava ◽

Urinary Sodium Excretion ◽

Basal Plasma ◽

Atrial Natriuretic

To evaluate the role of the atrial appendages in modulating plasma levels of atrial natriuretic peptide (ANP), we applied a series of both acute and chronic stimuli in conscious, chronic, bilaterally atrial-appendectomized (APP) and sham-operated control rats. Basal plasma ANP levels and urinary sodium excretion were normal in all rats after APP. The release of ANP was markedly blunted to acute volume expansion (+67% vs. +357% in controls, P less than 0.01) but was only moderately reduced after norepinephrine infusion (+106% vs. +212%, P less than 0.05) and was normal after acute salt load [+148% vs. +180% in controls, not significant (NS)]. Furthermore, plasma levels of ANP were increased normally in APP rats treated with deoxycorticosterone acetate (270 + 18 vs. 296 + 14 pg/ml in controls, NS) and in APP rats with congestive heart failure induced by a large arteriovenous (a-v) fistula between the aorta and the vena cava (306 +/- 18 vs. 302 +/- 12 pg/ml, NS). Sodium excretion patterns were similar in chronically stimulated APP and control rats. The results demonstrate that, although APP reduces the response of ANP release to acute volume expansion, it does not do so to other stimuli of either acute or chronic nature, suggesting that there is no permanent defect in the ability of APP rats to secrete ANP. These studies confirm that the atria are the major source for ANP release into the circulation after acute intravascular volume expansion. However, other tissue sources may contribute significantly to the levels of circulating ANP in response to this and other acute and chronic stimuli.

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