scholarly journals Gene Transfer of Manganese Superoxide Dismutase Extends Islet Graft Function in a Mouse Model of Autoimmune Diabetes

Diabetes ◽  
2003 ◽  
Vol 52 (2) ◽  
pp. 387-393 ◽  
Author(s):  
S. Bertera ◽  
M. L. Crawford ◽  
A. M. Alexander ◽  
G. D. Papworth ◽  
S. C. Watkins ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Gene Transfer ◽  
Mouse Model ◽  
Manganese Superoxide Dismutase ◽  
Autoimmune Diabetes ◽  
Graft Function ◽  
Islet Graft ◽  
Manganese Superoxide

Gene Transfer of Manganese Superoxide Dismutase Reverses Vascular Dysfunction in the Absence But Not in the Presence of Atherosclerotic Plaque

2001 ◽  
Vol 12 (11) ◽  
pp. 1407-1416 ◽  
Author(s):  
Michela Zanetti ◽  
Junichi Sato ◽  
Corey J. Jost ◽  
Peter Gloviczki ◽  
Zvonimir S. Katusic ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Gene Transfer ◽  
Atherosclerotic Plaque ◽  
Manganese Superoxide Dismutase ◽  
Vascular Dysfunction ◽  
Manganese Superoxide

scholarly journals Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta

2001 ◽  
Vol 280 (6) ◽  
pp. H2516-H2523 ◽  
Author(s):  
Michela Zanetti ◽  
Jun'Ichi Sato ◽  
Zvonimir S. Katusic ◽  
Timothy O'Brien
Keyword(s):  
Superoxide Dismutase ◽  
Endothelial Dysfunction ◽  
Gene Transfer ◽  
Manganese Superoxide Dismutase ◽  
Ex Vivo ◽  
Rabbit Aorta ◽  
Sod Activity ◽  
Manganese Superoxide ◽  
Diabetic Rabbit ◽  
Copper Zinc

Increased production of oxygen free radicals is an important mechanism of endothelial dysfunction in diabetes mellitus. Our goal was to test whether adenovirus (Ad)-mediated gene transfer of copper/zinc (CuZn) or manganese superoxide dismutase (Mn SOD) improves relaxation of diabetic vessels. The aortas from 9 alloxan-induced diabetic mellitus (DM) and 16 control rabbits were used. Control and DM rings were transduced ex vivo with Ad vectors encoding Mn SOD (AdMn SOD), CuZn SOD (AdCuZn SOD), β-galactosidase (Adβgal), or diluents. In the absence of gene transfer, SOD activity was significantly increased in DM aortas. Transgene expression in DM AdCuZn SOD and DM AdMn SOD-transduced vessels was confirmed by Western blot analysis and by increased SOD activity (DM AdCuZn SOD, 76.2 ± 9.3; DM AdMn SOD, 65.2 ± 4.8; P < 0.05 vs. DM Adβgal; 50.9 ± 4.4 U/mg protein). Superoxide production was increased in DM Adβgal-transduced aorta and relaxations to acetylcholine were impaired in these vessels. Gene transfer of CuZn SOD and Mn SOD corrected both of these defects. Thus Ad-mediated gene transfer CuZn and Mn SOD to the diabetic aorta improves endothelium-dependent relaxation.

scholarly journals Ginseng increases Klotho expression by FoxO3-mediated manganese superoxide dismutase in a mouse model of tacrolimus-induced renal injury

Aging ◽  
2019 ◽  
Vol 11 (15) ◽  
pp. 5548-5569 ◽  
Author(s):  
Sun Woo Lim ◽  
Yoo Jin Shin ◽  
Kang Luo ◽  
Yi Quan ◽  
Sheng Cui ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Mouse Model ◽  
Renal Injury ◽  
Manganese Superoxide Dismutase ◽  
Manganese Superoxide
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