scholarly journals Evaluating the Efficacy of Crisaborole Using the Atopic Dermatitis Severity Index and Percentage of Affected Body Surface Area

2020 ◽  
Vol 100 (13) ◽  
pp. adv00170
Author(s):  
J Silverberg ◽  
A Tallman ◽  
W Ports ◽  
R Gerber ◽  
H Tan ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Severity Index ◽  
Atopic Dermatitis Severity

The Self-Administered Eczema Area and Severity Index in Children with Moderate to Severe Atopic Dermatitis: Better Estimation of AD Body Surface Area Than Severity

2010 ◽  
Vol 27 (5) ◽  
pp. 470-475 ◽  
Author(s):  
Sara G.A. Van Velsen ◽  
Mirjam J. Knol ◽  
Inge M. Haeck ◽  
Carla A.F.M. Bruijnzeel-Koomen ◽  
Suzanne G.M.A. Pasmans
Keyword(s):  
Atopic Dermatitis ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Severity Index ◽  
The Self ◽  
Severe Atopic Dermatitis

Psoriasis: Moderne Versorgung braucht einen ganzheitlichen Ansatz

2019 ◽  
pp. 196-197
Author(s):  
Natalia Kirsten
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Mass ◽  
Body Surface ◽  
Vitamin D3 ◽  
Severity Index ◽  
Serum Concentrations ◽  
Depression Severity ◽  
Interleukin 18 ◽  
Psoriasis Area Severity Index

Objective: Psoriasis and depression may have common mechanisms, such as systemic inflammation, dysfunction of the hypothalamic-pituitary-adrenal axis, and vitamin D3 deficiency. Among men with psoriasis, this study examined whether depression severity was associated with serum concentrations of different metabolic and inflammatory markers.Methods: The study included 85 men with psoriasis (mean age ±standard deviation [SD], 47 ±14 years) and 65 men without psoriasis (mean age ±SD, 44 ±13 years). In both groups, we measured the body mass index; blood pressure; and serum concentrations of lipids, uric acid, lipase, interleukins 6 and 18, cortisol, and 25-hydroxyvitamin D3. All participants completed the Beck Depression Inventory. Other variables analyzed included psoriasis duration, the Psoriasis Area Severity Index, and the percentage of body surface area affected by psoriatic lesions.Results: Compared with controls, patients with psoriasis had significantly greater depression severity, higher body mass indices, and higher serum concentrations of total cholesterol and interleukins 6 and 18; moreover, they had significantly lower serum 25-hydroxyvitamin D3 concentrations. In patients with psoriasis, depression severity correlated positively with psoriasis duration, the Psoriasis Area Severity Index, the percentage of body surface area affected by psoriatic lesions, and interleukin-18 concentration. In patients with psoriasis, depression severity correlated negatively with 25-hydroxyvitamin D3 concentration, but it did not correlate significantly with the serum concentrations of interleukin 6 and cortisol. Conclusion: High concentrations of interleukin 18 and low concentrations of 25-hydroxyvitamin D3 may be associated with depression severity in men with psoriasis. Thus, further studies should examine whether effective anti-inflammatory treatments or vitamin D3 supplementation can improve depression outcomes in these patients.

scholarly journals PSORIASIS VULGARIS BERAT DITERAPI MIKOFENOLAT MOFETIL: TANTANGAN DALAM PENGOBATAN

2019 ◽  
Vol 46 (3) ◽  
Author(s):  
Hari Darmawan ◽  
Nopriyati
Keyword(s):  
Liver Injury ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Psoriasis Vulgaris ◽  
Severity Index ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Psoriasis merupakan penyakit kulit eritropapuloskuamosa kronik residif, ditandai lesi kulit khas plak eritematosa batas tegas ditutup skuama putih keperakan. Diagnosis psoriasis ditegakkan melalui anamnesis, pemeriksaan fisis, dan histopatologik. Psoriasis vulgaris berat diterapi mikofenolat mofetil (MMF) belum pernah dan baru pertama kali di Rumah Sakit Umum Pusat dr. Mohammad Hoesin Palembang. Pengalaman klinis, efikasi serta keamanan terapi MMF terbatas. Perempuan, 40 tahun, keluhan timbul bintil dan bercak merah meninggi ditutup sisik putih tebal pada hampir seluruh tubuh sejak 8 pekan lalu disertai gatal. Pada status dermatologikus tampak papul-plak eritem, multipel, lentikuler-plakat disertai skuama di regio fasialis, trunkus, ekstremitas anterior et posterior dextra et sinistra. Tanda Auspitz dan fenomena tetesan lilin positif. Biopsi histopatologik mendukung diagnosis psoriasis vulgaris. Skor psoriasis area and severity index (PASI) 20,4 dengan body surface area (BSA) 50%. Pasien diterapi MMF dan steroid topikal selama 12 pekan dan menunjukkan perbaikan PASI 75%, namun dirawat inap kembali dengan drug induced liver injury (DILI).Pilihan MMF karena saat ini metotreksat sulit didapat dan pasien alergi terhadap siklosporin. Perlu penelitian lebih banyak untuk menilai efikasi dan efek samping MMF dalam tatalaksana psoriasis vulgaris. Kata kunci: psoriasis vulgaris berat, mikofenolat mofetil, drug induced liver injury

27050 Efficacy of baricitinib 2-mg stratified by baseline body surface area in adults with moderate-to-severe atopic dermatitis

2021 ◽  
Vol 85 (3) ◽  
pp. AB128
Author(s):  
Jonathan I. Silverberg ◽  
Mark Boguniewicz ◽  
Jill Waibel ◽  
Jamie Weisman ◽  
Lindsey Strowd ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Severe Atopic Dermatitis
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