scholarly journals New Evidence of Enhanced Safety of Nitrous Oxide in General Anesthesia

2013 ◽  
Vol 60 (4) ◽  
pp. 143-144 ◽  
Author(s):  
Joel M. Weaver
1986 ◽  
Vol 62 (2) ◽  
pp. 587-591 ◽  
Author(s):  
Benno Bonke ◽  
Jože Rupreht ◽  
John H. M. Van Eijndhoven

Return of motor-responses upon request as an indicator of stimulus processing during apparent unconsciousness in general anesthesia was studied in 8 healthy, male volunteers during prolonged inhalation of nitrous oxide. First the minimal effective concentration of nitrous oxide was established for each volunteer, based upon continued absence of motor-responses to repeated verbal commands. One week later this concentration of nitrous oxide was administered for a 3-hr. period; return of motor-responses after at least 30 min. of absence was considered a sign of so-called unconscious perception. Four volunteers showed return of motor-response within the 3 hr. of exposure, but two of these had been rather restless throughout the session. Results indicate that unexpected processing of information by patients may occur during presumed unconsciousness after a prolonged inhalation of nitrous oxide in general anesthesia.


2017 ◽  
Vol 64 (3) ◽  
pp. 171-172
Author(s):  
Tomo Morota ◽  
Katsuya Endou ◽  
Hiroshi Omizo ◽  
Setsuo Furuta ◽  
Hisashi Miyajima

We report a case of endotracheal tube malfunction, in which the inner surface of the tube peeled off during anesthesia. The patient, a 7-year-old boy, was under general anesthesia for the treatment of multiple dental caries. The damaged tube could have caused respiratory failure, putting the patient's life at risk. We speculate that the use of nitrous oxide was one of the contributing factors to the inner wall detachment. Several additional lessons can be learned from this incident in order to prevent tube-related trouble during an operation.


1967 ◽  
Vol 40 (3) ◽  
pp. 928-931 ◽  
Author(s):  
Judah Folkman ◽  
David M. Long ◽  
Richard Rosenbaum

Abstract Ether, nitrous oxide, halothane, and cyclopropane diffuse through silicone rubber. General anesthesia can be produced in dogs by passing the vapors of any of these anesthetic agents through a coil of silicone rubber tubing, each end of which is placed in an artery and vein. Potential applications include a new method for general anesthesia and a simple accurate vaporizer for halothane.


1988 ◽  
Vol 69 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Van A. Doze ◽  
Audrey Shafer ◽  
Paul F. White

1963 ◽  
Vol 24 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Margaret C. Holderness ◽  
Patricia E. Chase ◽  
Robert D. Dripps

1975 ◽  
Vol 19 (3) ◽  
pp. 310
Author(s):  
MARGARET C. HOLDERNESS ◽  
PATRICIA E. CHASE ◽  
ROBERT D. DRIPPS

1996 ◽  
Vol 8 (8) ◽  
pp. 639-643 ◽  
Author(s):  
Cynthia A. Lien ◽  
Hugh C. Hemmings ◽  
Matthew R. Belmont ◽  
Amy Abalos ◽  
Charleen Hollmann ◽  
...  

2007 ◽  
Vol 106 (5) ◽  
pp. 952-955 ◽  
Author(s):  
Adelchi Toscano ◽  
Carlo Pancaro ◽  
Vito Aldo Peduto

Background Dreaming during anesthesia is not a well-understood phenomenon. Anticholinergic drugs are used in anesthesia as premedication, but their use to decrease the incidence of dreams and psychological adverse reactions after anesthesia is not well established. The authors therefore studied the efficacy of intramuscular atropine and scopolamine for the prevention of dreams during general anesthesia with propofol and nitrous oxide. Methods Healthy women undergoing minor gynecologic surgery were randomly assigned to receive 2.5 microg/kg scopolamine or 10 microg/kg atropine intramuscularly (n = 50/group). In both groups, anesthesia was induced and maintained with propofol as a 2.5-mg/kg bolus, followed by 12 mg x kg(-1) x h(-1) as a continuous infusion and 70% nitrous oxide in oxygen. Two interviews regarding dreaming activity and characteristics were conducted at 20 min and 6 h after surgery. Results None of the patients in the scopolamine group and 47% of the patients in the atropine group reported the occurrence of dreams 20 min after recovery. The results were similar at 6 h: 6% of the scopolamine group and 43% of the atropine group reported dream activity. No differences in sedation or anesthetic requirements were found. Conclusions Previous studies in animals and humans suggest that dreams are affected by drugs acting on the central cholinergic system. The current results suggest that intramuscular scopolamine prevents dreams or dream recall in healthy young women undergoing short elective surgery with propofol-nitrous oxide anesthesia.


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