Nontraumatic Intradural and Subdural Hemorrhage and Hypoxic Ischemic Encephalopathy in Fetuses, Infants, and Children up to Three Years of Age: Analysis of Two Audits of 636 Cases from Two Referral Centers in the United Kingdom

2013 ◽  
Vol 16 (3) ◽  
pp. 149-159 ◽  
Author(s):  
Irene Scheimberg ◽  
Marta C. Cohen ◽  
Rita E. Zapata Vazquez ◽  
Susan Dilly ◽  
Mudher Al Adnani ◽  
...  
Keyword(s):  
United Kingdom ◽  
Infants And Children ◽  
Hypoxic Ischemic Encephalopathy ◽  
Subdural Hemorrhage ◽  
The United Kingdom ◽  
Ischemic Encephalopathy

Evidence of Occurrence of Intradural and Subdural Hemorrhage in the Perinatal and Neonatal Period in the Context of Hypoxic Ischemic Encephalopathy: An Observational Study from Two Referral Institutions in the United Kingdom

2009 ◽  
Vol 12 (3) ◽  
pp. 169-176 ◽  
Author(s):  
Marta C. Cohen ◽  
Irene Scheimberg
Keyword(s):  
Thin Film ◽  
Hypoxic Ischemic Encephalopathy ◽  
Subdural Hemorrhage ◽  
Intrauterine Death ◽  
Venous Plexus ◽  
Neonatal Deaths ◽  
The United Kingdom ◽  
Degrees Of Severity ◽  
The Brain ◽  
Ischemic Encephalopathy

The occurrence of subdural hemorrhage (SDH) on the convexities of the cerebral hemispheres is not an unusual finding in the setting of intrauterine, perinatal, or neonatal deaths, the hemorrhage usually presenting either as a thin film over the occipital poles or as a small infratentorial bleed. Working in 2 referral centers with over 30 000 deliveries per year, we routinely examine the dura macroscopically and histologically in nonmacerated fetuses over 24 weeks in gestation and in neonates. This paper describes our experience of intradural hemorrhage (IDH) and SDH associated with hypoxia. Our series comprises 25 fetuses and 30 neonates with obvious macroscopic intradural hemorrhage and hypoxia of varying degrees of severity diagnosed by systematic examination of the brain. Fetal gestational age ranged from 26–41/40 weeks (all no more than 24 hours from intrauterine death), while the 30 neonates lived for between 1 hour and 19 days. Simultaneously with IDH, frank SDH was seen in 2 of 3 of all cases (16 fetuses and 20 neonates). Intradural hemorrhage was more prominent in the posterior falx and tentorium, most likely because of the existence of 2 venous plexus at these sites. Our findings demonstrate that SDH and cerebral hypoxia are common associations of IDH and that SDH (often seen as a thin film of hemorrhage) almost always occurs in association with diffuse falcine IDH. Diffuse IDH with SDH are more frequently associated with severe or moderate hypoxic ischemic encephalopathy (HIE), while mild or early HIE is more common with focal IDH without SDH.

Lack of Evidence for a Causal Relationship between Hypoxic-Ischemic Encephalopathy and Subdural Hemorrhage in Fetal Life, Infancy, and Early Childhood

2007 ◽  
Vol 10 (5) ◽  
pp. 348-350 ◽  
Author(s):  
Roger W. Byard ◽  
Peter Blumbergs ◽  
Guy Rutty ◽  
Jan Sperhake ◽  
Jytte Banner ◽  
...  
Keyword(s):  
Sudden Infant Death ◽  
The United States ◽  
Hypoxic Ischemic Encephalopathy ◽  
Sudden Infant ◽  
Subdural Hemorrhage ◽  
Fetal Life ◽  
Female Ratio ◽  
Infancy And Early Childhood ◽  
Age Range ◽  
Ischemic Encephalopathy

It has been asserted that hypoxic-ischemic encephalopathy (HIE) with cerebral swelling in the absence of marked trauma may be responsible for subural hemorrhage in the young. As this may have considerable implications in determining both the mechanism of death and the degree of force required to cause injury in certain cases of inflicted head injury in infancy, clarification is required. A retrospective study of 82 fetuses, infants, and toddlers with proven HIE and no trauma was undertaken from forensic institutes in Australia, the United Kingdom, Germany, Denmark, and the United States. The age range was 35 weeks gestation to 3 years, with a male to female ratio of 2:1. All cases had histologically confirmed HIE. Causes of the hypoxic episodes were temporarily resuscitated sudden infant death syndrome with delayed death (N = 30), drowning (N = 12), accidental asphyxia (N = 10), intrauterine/delivery asphyxia (N = 8), congenital disease (N = 6), aspiration of food/gastric contents (N = 4), inflicted asphyxia (N = 3), epilepsy (N = 1), dehydration (N = 1), drug toxicity (N = 1), complications of prematurity (N = 1), and complications of anesthesia (N = 1). The initiating event was not determined in 4 instances. In no case was there macroscopic evidence of subdural hemorrhage. In this study no support could be given to the hypothesis that HIE in the young in the absence of trauma causes subdural hemorrhage.

A comparison of the United Kingdom Clinical Aptitude Test (UK-CAT) with a traditional admission selection process

2009 ◽  
pp. 1-6 ◽  
Author(s):  
Nishan Fernando ◽  
Gordon Prescott ◽  
Jennifer Cleland ◽  
Kathryn Greaves ◽  
Hamish McKenzie
Keyword(s):  
United Kingdom ◽  
Selection Process ◽  
Aptitude Test ◽  
The United Kingdom

Research on Schizophrenia: A View From the United Kingdom

1990 ◽  
Vol 35 (8) ◽  
pp. 800-801
Author(s):  
Michael F. Pogue-Geile
Keyword(s):  
United Kingdom ◽  
The United Kingdom

In the United Kingdom, Employed Women Have Problems, Too

1992 ◽  
Vol 37 (10) ◽  
pp. 1076-1077
Author(s):  
Barbara A. Gutek
Keyword(s):  
United Kingdom ◽  
The United Kingdom ◽  
Employed Women
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