scholarly journals Microvessel Density and Expression of Vascular Endothelial Growth Factor and Its Receptors in Diffuse Large B-Cell Lymphoma Subtypes

2007 ◽  
Vol 170 (4) ◽  
pp. 1362-1369 ◽  
Author(s):  
Dita Gratzinger ◽  
Shuchun Zhao ◽  
Robert J. Marinelli ◽  
Amy V. Kapp ◽  
Robert J. Tibshirani ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
B Cell ◽  
Microvessel Density ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Vascular Endothelial ◽  
Large B Cell Lymphoma ◽  
Endothelial Growth Factor ◽  
Large B Cell

Primary cutaneous diffuse large B-cell lymphoma, leg type, with expression of both vascular endothelial growth factor and its receptors

2009 ◽  
Vol 33 (11) ◽  
pp. e181-e183 ◽  
Author(s):  
Shoko Nakayama ◽  
Taiji Yokote ◽  
Kichinosuke Kobayashi ◽  
Yuji Hirata ◽  
Toshikazu Akioka ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Vascular Endothelial ◽  
Large B Cell Lymphoma ◽  
Endothelial Growth Factor ◽  
Large B Cell

scholarly journals Angiogenesis’ related genetic variants alter clinical features and prognosis of diffuse large B-cell lymphoma patients

Tumor Biology ◽  
2021 ◽  
Vol 43 (1) ◽  
pp. 129-140
Author(s):  
Angelo Borsarelli Carvalho Brito ◽  
Marcia Torresan Delamain ◽  
Marcello Ferreti Fanelli ◽  
Fernando Augusto Soares ◽  
Cármino Antônio de Souza ◽  
...  
Keyword(s):  
B Cell ◽  
Clinical Features ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Vascular Endothelial ◽  
Single Nucleotide Variants ◽  
Large B Cell Lymphoma ◽  
Increased Risk ◽  
Endothelial Growth Factor ◽  
Large B Cell

OBJECTIVES: Single nucleotide variants (SNVs) in vascular endothelial growth factor A (VEGFA) and VEGFA receptor (KDR) genes confer different inherited abilities in angiogenesis (AG) pathway. We aimed in the present study to evaluate influence of six VEGFA and four KDR SNVs in clinical features and survival of diffuse large B-cell lymphoma (DLBCL) patients. METHODS: One hundred and sixty-eight DLBCL patients diagnosed between June 2009-September 2014 were enrolled in the study. Patients were homogeneously treated with R-CHOP. Genotypes were identified in genomic DNA by real-time polymerase chain reaction. RESULTS: Patients with VEGFA -634CC and +936CT or TT genotypes were at increased risk of showing grade III / IV toxicities and not achieving complete remission with treatment, and shorter event-free and overall survival were seen in patients with VEGFA -1154GA or AA genotype and VEGFA ATAGCC haplotype. CONCLUSION: Our data suggest that inherited abnormalities in AG’s gene modulate clinical features and prognosis of DLBCL patients homogeneously treated with R-CHOP.

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