Malignant phyllodes tumor of the breast with spinal metastasis: case report and review of literature

Phyllodes tumor (PT) is a rare tumor of the breast accounting for approximately 1% of all breast neoplasms. In 1838, J. Muller coined the term “cystosarcoma phyllodes” based on the leaf-like projections of the tumor extending into the cystic spaces and sarcomatous stromal growth. However, seeing as up to 70% of phyllodes tumors are benign, “cystosarcoma” was removed, and the tumor is now recognized simply as phyllodes tumor. It is mainly seen in females between the ages of 35 and 55. Although most phyllodes tumors are benign, malignant cases do uncommonly occur, 22% of which have distant metastasis typically to the lungs and bones. Rarely, this tumor metastasizes to other locations. Herein, we report a case of malignant phyllodes tumor with metastasis to the pancreas. According to our knowledge, only 3 case reports of pancreatic metastasis from malignant phyllodes tumor have been reported in literature thus far. We aim to increase awareness among physicians of this rare metastasic potential of the uncommonly encountered malignant phyllodes tumor.

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A giant malignant phyllodes tumor of breast post mastectomy with metastasis to stomach manifesting as anemia: a case report and review of literature

BMC Surgery ◽

10.1186/s12893-020-00846-0 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Hui-Pu Liu ◽

Wen-Yen Chang ◽

Chin-Wen Hsu ◽

Shan-Tao Chien ◽

Zheng-Yi Huang ◽

...

Keyword(s):

Case Report ◽

Phyllodes Tumor ◽

Review Of Literature ◽

Malignant Phyllodes Tumor

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Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature

Indian Journal of Pathology and Microbiology ◽

10.4103/ijpm.ijpm_238_17 ◽

2018 ◽

Vol 61 (4) ◽

pp. 577 ◽

Cited By ~ 1

Author(s):

SwethaLakshmi Narla ◽

Punitha Stephen ◽

Ann Kurian ◽

S Annapurneswari

Keyword(s):

Case Report ◽

Pregnant Woman ◽

Rare Case ◽

Phyllodes Tumor ◽

Review Of Literature ◽

Malignant Phyllodes Tumor ◽

Rare Case Report ◽

Well Differentiated

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Malignant Phyllodes Tumor Including Aneurysmal Bone Cyst-Like Areas in Pregnancy - a Case Report and Review of the Literature

Breast Care ◽

10.1159/000448236 ◽

2016 ◽

Vol 11 (4) ◽

pp. 291-294 ◽

Cited By ~ 1

Author(s):

Canan Kelten ◽

Ceren Boyaci ◽

Cem Leblebici ◽

Kemal Behzatoglu ◽

Didem C. Trabulus ◽

...

Keyword(s):

Case Report ◽

Bone Cyst ◽

Clinical Breast Examination ◽

Phyllodes Tumor ◽

Breast Cancer Diagnosis ◽

Left Breast ◽

Malignant Phyllodes Tumor ◽

Her Family ◽

Simple Mastectomy ◽

Clinical Breast

Background: Malignant phyllodes tumors of the breast are rare biphasic neoplasms. Only few cases related to pregnancy have been reported. Case Report: A 37-year-old woman presented with swelling and pain in her left breast as well as hyperemia on the breast skin, 4 weeks after labor. In her family history, her aunt and maternal cousin had had a breast cancer diagnosis. Clinical evaluation of the patient was consistent with a breast abscess. Therefore, abscess drainage and biopsy from the cavity wall were performed. However, the biopsy was diagnosed as malignant phyllodes tumor. An evaluation by ultrasonography showed a well-defined hypoechoic mass with many cystic spaces covering the entire breast tissue. Therefore, a simple mastectomy was performed. Microscopic examination revealed a high-grade malignant phyllodes tumor. Additionally, bone cyst-like areas in the form of sponge-like blood-filled non-endothelialized spaces were observed. Conclusions: Since the breasts become larger due to the physiological changes during pregnancy, any underlying breast lesions may be obscured. Therefore, clinical breast examination in the first visit of pregnancy is important.

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