scholarly journals A Suspected Ovarian Cancer in a Postmenopausal Woman That Turned Out to Be a Broad Ligament Leiomyoma with Extensive Hydropic Degeneration

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Polepalle Thoshya ◽  
Fernandopulle Navindi Hasara ◽  
Raut Jaydip
Keyword(s):  
Ovarian Cancer ◽  
Postmenopausal Woman ◽  
Broad Ligament ◽  
Hydropic Degeneration

Management of high, moderate, and low penetrance ovarian cancer susceptibility mutations: an assessment of current risk reduction practices

2020 ◽  
Vol 30 (10) ◽  
pp. 1583-1588
Author(s):  
Catherine H. Watson ◽  
Lindsay Soo ◽  
Brittany A. Davidson ◽  
Laura J. Havrilesky ◽  
Paula S. Lee ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Postmenopausal Woman ◽  
Risk Reduction ◽  
Premenopausal Woman ◽  
Cancer Susceptibility ◽  
Gynecologic Oncology ◽  
Reduction Strategies ◽  
Risk Reduction Strategies ◽  
Risk Reducing ◽  
Current Risk

ObjectiveLimited information exists regarding risk reduction strategies for women with moderate and low penetrance ovarian cancer susceptibility mutations. We sought to assess current risk reduction practice patterns for carriers of these mutations through a survey of members of the Society of Gynecologic Oncology.MethodsSociety of Gynecologic Oncology members were emailed a survey consisting of two vignettes: (1) a 35-year-old premenopausal woman; (2) a 55-year-old postmenopausal woman with comorbidities. Each vignette contained sub-scenarios in which the patient had either a BRCA1 (relative risk (RR)=30–60), RAD51C (RR=5.0), or ATM (RR=1.5–2.0) mutation. Respondents were queried about their preferred management approach. Summary statistics were performed to describe results of the survey. We used χ2 testing for statistical analyses, comparing results according to mutation type and demographic information.ResultsA total of 193 (15%) of 1284 Society of Gynecologic Oncology members responded. For the premenopausal woman, 99%, 80%, and 40% would perform a risk reducing salpingo-oophorectomy prior to menopause in the setting of a BRCA1, RAD51C, and ATM mutation, respectively. For the postmenopausal woman, 98%, 85%, and 42% would proceed with risk reducing salpingo-oophorectomy in the setting of a BRCA1, RAD51C, and ATM mutation, respectively. Response distribution for carriers of RAD51C and ATM mutations were different from BRCA1 in both vignettes (p<0.001).ConclusionsRespondents were more likely to perform risk reducing salpingo-oophorectomy, in the setting of a BRCA1, RAD51C, and ATM mutation, earlier and more frequently in the setting of a BRCA1 mutation. However, there was a lack of consensus about management of the moderate and low penetrance mutations, suggesting that more data regarding age specific risks and appropriate risk reduction strategies for these alterations are needed.

Cotyledonoid Leiomyoma

2002 ◽  
Vol 126 (2) ◽  
pp. 210-213
Author(s):  
W. Cheuk ◽  
John K. C. Chan ◽  
John Y. S. Liu
Keyword(s):  
Uterine Leiomyoma ◽  
Uterine Prolapse ◽  
Broad Ligament ◽  
Growth Patterns ◽  
Brown Tumor ◽  
Coagulative Necrosis ◽  
Provisional Diagnosis ◽  
Hydropic Degeneration ◽  
Total Hysterectomy ◽  
The Right

Abstract Cotyledonoid leiomyoma or “grapelike” leiomyoma is a very rare tumor among the ever-expanding repertoire of growth variants described in benign uterine leiomyoma. We report a case of cotyledonoid leiomyoma in a 55-year-old woman who presented with menorrhagia and uterine prolapse. A large multinodular fungating tumor adhering to the right posterolateral wall of the uterus and extending to the broad ligament was discovered at vaginal hysterectomy. With a provisional diagnosis of sarcoma, total hysterectomy and bilateral salpingo-oophorectomy were performed. Postoperatively, the patient was well with no evidence of recurrence at 14 months. Pathologic examination revealed a 10-cm, red-brown tumor that comprised multiple bulbous processes protruding over the uterine surface, in continuity with a dissecting intramyometrial component. It was composed of fascicles and nodules of bland-looking smooth muscle cells with prominent perinodular hydropic degeneration. Coagulative necrosis, mitoses, and nuclear atypia were absent. Cotyledonoid leiomyoma apparently results from a combination of several uncommon growth patterns operating together, including subserosal growth, dissecting growth, and perinodular hydropic degeneration. Increased awareness of this grossly alarming variant of benign uterine leiomyoma can help avoid overtreatment.

Management of high, moderate, and low penetrance ovarian cancer susceptibility gene mutations: An assessment of current practice patterns.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 1536-1536
Author(s):  
Catherine H. Watson ◽  
Brittany Anne Davidson ◽  
Laura Jean Havrilesky ◽  
Paula S. Lee ◽  
Leah McNally ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Postmenopausal Woman ◽  
Risk Reduction ◽  
Premenopausal Woman ◽  
Current Practice ◽  
Practice Patterns ◽  
Management Approach ◽  
Limited Information ◽  
Reduction Strategies ◽  
Risk Reduction Strategies

1536 Background: Limited information exists regarding appropriate risk-reduction strategies for women with moderate and low penetrance ovarian cancer (OVCA) susceptibility mutations. We sought to assess current practice patterns for women with these genetic changes through a survey of members of the Society of Gynecologic Oncology (SGO). Methods: All full SGO members were e-mailed a survey consisting of two vignettes: 1) a 35-year-old premenopausal woman who desires pregnancy; 2) a 55-year-old postmenopausal woman with multiple comorbidities. Each vignette contained sub-scenarios in which the patient had either a BRCA1 (RR = 30-60), RAD51C (RR = 5.0) or ATM (RR 1.5-2.0) OVCA susceptibility mutation. Respondents were queried about their preferred management approach. Chi-square test was used for statistical analysis. Results: 193 (15%) of 1284 SGO members responded. 58% were in academic practice. For the premenopausal woman, 52%, 13% and 6% would perform an RRSO prior to age 40 in the setting of a BRCA1, RAD51C and ATM mutation respectively. 47%, 68% and 9% would perform RRSO at 40-50; and 0%, 9% and 23% would perform RRSO at menopause, depending on the gene mutated. For the postmenopausal woman with comorbidities, 98%, 85% and 42% would proceed with RRSO in the setting of a BRCA1, RAD51C and ATM mutation respectively; 2%, 8% and 39% would observe (with/without screening); and 0%, 7% and 19% would do further research prior to proceeding. Distribution of responses for carriers of RAD51C and ATM mutations were different from BRCA1 in both vignettes [p < 0.001]. Conclusions: Respondents were more likely to perform RRSO earlier and more frequently in the setting of a BRCA1 mutation compared to either a RAD51C or ATM mutation. However, there was lack of consensus in management of the moderate and low penetrance OVCA susceptibility mutations. These patterns likely reflect the limited information available regarding the timing and magnitude of risk associated with these genes. Given the immediate and long-term morbidity of oophorectomy, more data regarding age-specific risks and appropriate risk-reduction strategies for moderate and low penetrance OVCA susceptibility mutations is needed.

scholarly journals Severely calcified leiomyoma of broad ligament in a postmenopausal woman: Report of a rare case

2016 ◽  
Vol 7 (3) ◽  
pp. 147
Author(s):  
Subrata Pal ◽  
Sajeeb Mondal ◽  
Palash Kr Mondal ◽  
Gargi Raychaudhuri ◽  
Rajashree Pradhan ◽  
...  
Keyword(s):  
Postmenopausal Woman ◽  
Rare Case ◽  
Broad Ligament
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