scholarly journals Meta-Analysis, Ideals of Objectivity, and the Reliability of Medical Knowledge

2015 ◽  
Vol 28 (3) ◽  
pp. 101-121
Author(s):  
Saana Jukola

This paper focuses on the ideals of scientific objectivity as they emerge in discussions concerning meta-analyses and medical research. Stegenga (2011) has argued that meta-analyses fail to be objective because conducting them involves making judgments. I show that his reasoning is based on the so-called procedural ideal of objectivity, which can be questioned: this ideal is unattainable and does not capture some of the problematic issues of medical research. By introducing a case in research on selective serotonin reuptake inhibitors, I demonstrate why the so-called social view on objectivity succeeds better in accommodating 1) the way in which scientific research necessarily involves judgments, 2) the possible risks involved in research, and 3) the influence that the institutional context has on research activities. Adopting this ideal of objectivity helps us better appreciate the virtues of meta-analyses and pinpoint which practices threaten the reliability of meta-analyses’ results.

Dose-Response ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 155932582090235
Author(s):  
Shih-Wei Lai ◽  
Cheng-Chan Yu ◽  
Cheng-Li Lin ◽  
Kuan-Fu Liao

Background/Objective: Some case series and case report have shown the association between the risk of acute pancreatitis and use of selective serotonin reuptake inhibitors. The results of systematic studies were not consistent. Methods: A meta-analysis was performed to investigate the risk of acute pancreatitis associated with use of selective serotonin reuptake inhibitors. Results: There was no statistical association between the risk of acute pancreatitis and selective serotonin reuptake inhibitors use (odds ratio: 1.19, 95% confidence interval: 0.93-1.51). Conclusions: Despite reaching no statistical significance, the possibility of the association between the risk of acute pancreatitis and selective serotonin reuptake inhibitors use cannot be totally excluded.


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