scholarly journals Analysis between vitamin D receptor Bsml polymorphism and exocrine pancreatic insufficiency in patients with comorbidity: chronic pancreatitis and chronic obstructive pulmonary disease

2021 ◽  
Vol 25 (2(98)) ◽  
pp. 68-74
Author(s):  
T. Lazaruk ◽  
O. Fediv ◽  
O. Olinyk
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Chronic Pancreatitis ◽  
Vitamin D Deficiency ◽  
Pulmonary Disease ◽  
Pancreatic Insufficiency ◽  
Serum Vitamin ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Serum Vitamin D

The objective of the research is to analyze the association of Bsml polymorphism of the vitamin D receptor gene in patients with comorbidity - chronic pancreatitis (CP) and chronic obstructive pulmonary disease (COPD), as well as to correct the serum vitamin D level.Material and methods. The study included 57 patients with CP with concomitant COPD, who were hospitalized in the gastroenterology department of the Chernivtsi Regional Clinical Hospital. COPD was in a state of stable or unstable remission. The average age of the examined patients was 52.36 ± 1.83 years. The inclusion criterion was vitamin D deficiency diagnosed in patients with chronic pancreatitis and chronic obstructive pulmonary disease. The exclusion criterion was another nosology that could cause disorders of vitamin D metabolism. Results. 57 patients had vitamin D deficiency. No patients with normal vitamin levels were recorded. Thus, the average level of vitamin D in respondents with vitamin D deficiency was 36.13 ± 7.61. After genotyping and distribution according to a specific genotype, a vitamin deficiency correction scheme was selected. Cholecalciferol at a dose of 6000 IU for 2 months was prescribed for the G/G genotype patients. Patients with G/A and A/A genotypes received the same drug at a dose of 8000 IU for 2 months, followed by determination of serum vitamin D levels.Conclusions. For patients with A allele (genotypes AA and AG), the genetic risk of developing vitamin D deficiency is higher than the average population level. For patients with moderate and severe exocrine pancreatic insufficiency and signs of malabsorption syndrome, it is recommended to check not only the level of 25 (OH) D in the serum, but also to determine the polymorphic variant of the VDR gene to approve further treatment tactics - determine the optimal dose and check its effectiveness.

scholarly journals Serum Vitamin D levels in Chronic Obstructive Pulmonary Disease

2017 ◽  
Vol 5 (2) ◽  
pp. 128-136
Author(s):  
Dr. Ajay Kumar ◽  
◽  
Dr. Sanjay Tandon ◽  
Dr. S T Nagdeote ◽  
Dr. Kapil Sharma ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Pulmonary Disease ◽  
Serum Vitamin ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The Effect of Serum Vitamin D Level in Korean Chronic Obstructive Pulmonary Disease (COPD) Patients

CHEST Journal ◽  
2014 ◽  
Vol 145 (3) ◽  
pp. 388A
Author(s):  
Ji Ye Jung ◽  
Ah Young Leem ◽  
Eu Dong Hwang ◽  
Song Yee Kim ◽  
Se Kyu Kim ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Pulmonary Disease ◽  
Serum Vitamin ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Serum Vitamin D ◽  
Copd Patients

scholarly journals General Assessment of Calcium-Phosphorus Metabolism and Vitamin D Levels in Patients with Chronic Pancreatitis and Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol 6 (1) ◽  
pp. 96-100
Author(s):  
T. Yu. Lazaruk ◽  
◽  
O. I. Fediv
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Chronic Pancreatitis ◽  
Pulmonary Disease ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Chronic Obstructive ◽  
Phosphorus Metabolism ◽  
Obstructive Pulmonary Disease ◽  
Calcium Phosphorus

Our attention was drawn to the comorbidity of chronic pancreatitis and chronic obstructive pulmonary disease, namely the features of clinical and pathogenetic links. The article examines metabolism of vitamin D, parathyroid hormone and calcium-phosphorus metabolism in patients with this comorbidity and considering exocrine insufficiency. The results of our own research in this direction are presented. The purpose of the study was to determine the nature of the exocrine pancreatic insufficiency effect on the metabolism of vitamin D, parathyroid hormone and calcium-phosphorus metabolism. Material and methods. The study included 30 patients with exacerbation of chronic pancreatitis and 50 patients with a diagnosis of chronic pancreatitis in the acute stage and chronic obstructive pulmonary disease aged 47-55 years (average age – 52.36±1.83 years). All patients had chronic pancreatitis for more than 10 years. Inclusion criteria was the presence of exocrine pancreatic insufficiency and changes of vitamin D in patients’ metabolism. Patients were hospitalized in the gastroenterology department of the Regional Clinical Hospital, Chernivtsi, Ukraine in connection with exacerbation of chronic pancreatitis. Chronic obstructive pulmonary disease was in stable or unstable remission. Respondents were informed about the study and gave their consent. The control group consisted of 20 healthy individuals. Results and discussion. We revealed a complication of the clinical course in patients with chronic pancreatitis and chronic obstructive pulmonary disease on the background of exocrine pancreatic insufficiency. One of the manifestations was a violation of the metabolism of vitamin D, parathyroid hormone and calcium-phosphorus metabolism. Correlation analysis revealed a positive relationship between levels of exocrine pancreatic insufficiency and serum vitamin D concentration (p <0.05, r = 0.71). There was a strong inverse correlation between the levels of parathyroid hormone and vitamin D (p <0.05, r = - 0.87), and the content of calcium in the serum (p <0.05, r = - 0.74). Conclusion. Comorbidity of chronic pancreatitis and chronic obstructive pulmonary disease causes severe disorders of mineral metabolism and metabolism of vitamin D

scholarly journals Serum Vitamin D Level in Chronic Obstructive Pulmonary Disease and its Relation with Severity: A Single Centre Study

2019 ◽  
Vol 41 (2) ◽  
pp. 56-58
Author(s):  
Pankaj Pant ◽  
Shovit Thapa ◽  
Santa K Das ◽  
Niraj Bam
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Pulmonary Disease ◽  
Serum Vitamin ◽  
Stage Ii ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Low Serum

Introduction: Chronic obstructive pulmonary disease (COPD) is a public health problem of epidemic proportion. Several studies have shown low serum vitamin D levels in patients with COPD. The aim of this study was to compare serum vitamin D level in patients with Global Initiative for Chronic Obstructive Lung Diseases (GOLD) COPD stage II, III and IV with controls and correlate serum vitamin D level with severity of COPD. Methods: A cross sectional study was conducted from June 2014 to November 2015 at Tribhuvan University Teaching Hospital (TUTH). A total of 154 subjects were enrolled for study that consisted of 77 cases of COPD and 77 controls for comparison. Participants were taken from medical wards and outpatient department. COPD staging was done as per GOLD guidelines and stage II, III and IV were labeled as advanced COPD cases. Both descriptive and inferential statistics were performed in SPSS version 20. Results: Stage II, III and IV COPD were 30%, 36% and 34% respectively. Mean serum vitamin D level was 15.16±7.19 ng/ml in COPD cases and 33.99±12.37 ng/ml in healthy controls showing statistically significant relation of low serum vitamin D in patients with advanced COPD (p <0.0001). Serum vitamin D was found to be in decreasing trend with increasing severity of COPD. Conclusion: Patients with advanced COPD (GOLD stage II, III and IV) had low serum vitamin D levels compared to normal population and serum vitamin D level correlated with GOLD severity in Nepalese patients with COPD.

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