RUSSIA’S FIRST CLINICAL CASE OF A CHILD WITH MABRY’S SYNDROME (HYPERPHOSPHATASIA, MENTAL RETARDATION AND EPILEPSY) IN COMBINATION WITH HIRSCHSPRUNG’S DISEASE
The article presents a literature review of a rare congenital disease, hyperphosphatasia syndrome with mental retardation (Mabry's syndrome) in children. This syndrome is characterized by a triad of symptoms: hyperphosphatasia, epilepsy and mental retardation, often associated developmental defects. To date, 114 patients have been described. The review presents the available literary sources with clinical observations of patients since 1970, when the syndrome was first described by the pediatrician Ch. Mabry. The data on genetic defects leading to the disease are presented. The scheme of development of pyridoxine-sensitive epilepsy, the most severe manifestation of the syndrome, is described. The first clinical case of the patient with Mabry's syndrome in combination with Hirschsprung's disease in Russia is described.