The risks of a new hypothesis: why did JUPITER patients have almost twice the predicted event rate of reduction?

2011 ◽  
Vol 12 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Gregory A Sgueglia ◽  
Filippo Crea
Keyword(s):  
2002 ◽  
Author(s):  
H. W. Moises ◽  
T. Zoega ◽  
I. I. Gottesman
Keyword(s):  

1990 ◽  
Vol 29 (03) ◽  
pp. 243-246 ◽  
Author(s):  
M. A. A. Moussa

AbstractVarious approaches are considered for adjustment of clinical trial size for patient noncompliance. Such approaches either model the effect of noncompliance through comparison of two survival distributions or two simple proportions. Models that allow for variation of noncompliance and event rates between time intervals are also considered. The approach that models the noncompliance adjustment on the basis of survival functions is conservative and hence requires larger sample size. The model to be selected for noncompliance adjustment depends upon available estimates of noncompliance and event rate patterns.


2020 ◽  
Vol 91 (4) ◽  
pp. 352-357
Author(s):  
Jessica Tedford ◽  
Valerie Skaggs ◽  
Ann Norris ◽  
Farhad Sahiar ◽  
Charles Mathers

INTRODUCTION: Atrial fibrillation (AF) is one of the most common cardiac arrhythmias in the general population and is considered disqualifying aeromedically. This study is a unique examination of significant outcomes in aviators with previous history of both AF and stroke.METHODS: Pilots examined by the FAA between 2002 and 2012 who had had AF at some point during his or her medical history were reviewed, and those with an initial stroke or transient ischemic attack (TIA) during that time period were included in this study. All records were individually reviewed to determine stroke and AF history, medical certification history, and recurrent events. Variables collected included medical and behavior history, stroke type, gender, BMI, medication use, and any cardiovascular or neurological outcomes of interest. Major recurrent events included stroke, TIA, cerebrovascular accident, death, or other major events. These factors were used to calculate CHA2DS2-VASc scores.RESULTS: Of the 141 pilots selected for the study, 17.7% experienced a recurrent event. At 6 mo, the recurrent event rate was 5.0%; at 1 yr, 5.8%; at 3 yr 6.9%; and at 5 yr the recurrent event rate was 17.3%. No statistical difference between CHA2DS2-VASc scores was found as it pertained to number of recurrent events.DISCUSSION: We found no significant factors predicting risk of recurrent event and lower recurrence rates in pilots than the general population. This suggests CHA2DS2-VASc scores are not appropriate risk stratification tools in an aviation population and more research is necessary to determine risk of recurrent events in aviators with atrial fibrillation.Tedford J, Skaggs V, Norris A, Sahiar F, Mathers C. Recurrent stroke risk in pilots with atrial fibrillation. Aerosp Med Hum Perform. 2020; 91(4):352–357.


2008 ◽  
Vol 35 (2) ◽  
pp. 306-318 ◽  
Author(s):  
C. LAVERS ◽  
M. KNAPP

Khutū was a material derived from an animal used by Medieval Asian peoples in the manufacture of knife handles and as an alexipharmic. Al-Bīrūnī (973–1048) made extensive enquiries into the origin of khutū but reached no definite conclusion. Literary scholars in the first half of the twentieth century identified the walrus and narwhal as probable sources, but in ignoring aspects of the literature on khutū’s appearance and provenance left a number of questions unanswered. We clarify and extend this research and identify further clues to the identity of khutū. We concur that walrus ivory was one source of khutū, suggest that the remains of “Ice Age” mammals may have influenced development of the medieval literature on khutū more than previous investigators realized, and offer a new hypothesis of khutū’s origin.


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