Congenital diaphragmatic hernia after exposure to a triple retinoic acid antagonist during pregnancy

2017 ◽  
Vol 18 (5) ◽  
pp. 389-392 ◽  
Author(s):  
Daria Cipollone ◽  
Denis A. Cozzi ◽  
Rita Businaro ◽  
Bruno Marino
Keyword(s):  
Retinoic Acid ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Acid Antagonist

Prenatal treatment with retinoic acid promotes pulmonary alveologenesis in the nitrofen model of congenital diaphragmatic hernia

2008 ◽  
Vol 43 (3) ◽  
pp. 500-507 ◽  
Author(s):  
Sandra Montedonico ◽  
Kaoru Sugimoto ◽  
Patrick Felle ◽  
John Bannigan ◽  
Prem Puri
Keyword(s):  
Retinoic Acid ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Prenatal Treatment

Lung and liver growth and retinoic acid status in human fetuses with congenital diaphragmatic hernia

2018 ◽  
Vol 116 ◽  
pp. 17-23 ◽  
Author(s):  
Christine K.C. Loo ◽  
Michael A. Pearen ◽  
Tamara N. Pereira ◽  
Joanna Perry-Keene ◽  
Diane Payton ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Human Fetuses ◽  
Liver Growth ◽  
Acid Status

Effects of maternal retinoic acid administration in a congenital diaphragmatic hernia rabbit model

2008 ◽  
Vol 43 (6) ◽  
pp. 594-603 ◽  
Author(s):  
Denis Gallot ◽  
Karen Coste ◽  
Jacques Jani ◽  
Xenia Roubliova ◽  
Geoffroy Marceau ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Rabbit Model ◽  
Acid Administration

scholarly journals Perspective on Similarities and Possible Overlaps of Congenital Disease Formation—Exemplified on a Case of Congenital Diaphragmatic Hernia and Neuroblastoma in a Neonate

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 163
Author(s):  
Zihe Huo ◽  
Remo Bilang ◽  
Benedikt Brantner ◽  
Nicolas von der Weid ◽  
Stefan G. Holland-Cunz ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Cell Differentiation ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Rare Diseases ◽  
Simultaneous Presentation ◽  
Congenital Disease ◽  
Disease Entities ◽  
Acid Pathway ◽  
Neonatal Tumor

The coincidence of two rare diseases such as congenital diaphragmatic hernia (CDH) and neuroblastoma is exceptional. With an incidence of around 2–3:10,000 and 1:8000 for either disease occurring on its own, the chance of simultaneous presentation of both pathologies at birth is extremely low. Unfortunately, the underlying processes leading to congenital malformation and neonatal tumors are not yet thoroughly understood. There are several hypotheses revolving around the formation of CDH and neuroblastoma. The aim of our study was to put the respective hypotheses of disease formation as well as known factors in this process into perspective regarding their similarities and possible overlaps of congenital disease formation. We present the joint occurrence of these two rare diseases based on a patient presentation and immunochemical prognostic marker evaluation. The aim of this manuscript is to elucidate possible similarities in the pathogeneses of both disease entities. Discussed are the role of toxins, cell differentiation, the influence of retinoic acid and NMYC as well as of hypoxia. The detailed discussion reveals that some of the proposed pathophysiological mechanisms of both malformations have common aspects. Especially disturbances of the retinoic acid pathway and NMYC expression can influence and disrupt cell differentiation in either disease. Due to the rarity of both diseases, interdisciplinary efforts and multi-center studies are needed to investigate the reasons for congenital malformations and their interlinkage with neonatal tumor disease.

Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia

2014 ◽  
Vol 49 (6) ◽  
pp. 876-881 ◽  
Author(s):  
Florian Friedmacher ◽  
Naho Fujiwara ◽  
Alejandro D. Hofmann ◽  
Hiromizu Takahashi ◽  
Luis A.J. Alvarez ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Rat Lungs
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