Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia

2013 ◽  
Vol 30 (2) ◽  
pp. 137-142 ◽  
Author(s):  
Balazs Kutasy ◽  
Florian Friedmacher ◽  
Johannes W. Duess ◽  
Prem Puri
Keyword(s):  
Retinoic Acid ◽  
Growth Factor ◽  
Protein Expression ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Insulin Like Growth Factor

Modulation by retinoic acid of insulin-like growth factor (IGF) and IGF binding protein expression in human SK-N-SH neuroblastoma cells

1996 ◽  
Vol 134 (4) ◽  
pp. 474-480 ◽  
Author(s):  
Sylvie Babajko ◽  
Michel Binoux
Keyword(s):  
Retinoic Acid ◽  
Growth Factor ◽  
Protein Expression ◽  
Binding Protein ◽  
Neuroblastoma Cells ◽  
Insulin Like Growth Factor ◽  
Igf Binding ◽  
Igf Receptor ◽  
Igf Binding Protein

Babajko S, Binoux M. Modulation by retinoic acid of insulin-like growth factor (IGF) and IGF binding protein expression in human SK-N-SH neuroblastoma cells. Eur J Endocrinol 1996;134:474–80. ISSN 0804–4643 Growth in neuroblastoma cells is regulated by insulin-like growth factors (IGFs) whose action is modulated by IGF binding proteins (IGFBPs). In this study, SK-N-SH neuroblastoma cells were shown to produce IGF-II, IGFBP-2, IGFBP-4 and small quantities of IGFBP-6. We have studied the effects of a natural morphogen, retinoic acid (RA), on growth and IGFBP expression in these cells. In all experiments, cells were cultured in serum-free medium and treated with 1 μmol/l RA for 12 h. Cell number increased by almost 50% during the first 24 h after the beginning of treatment. This stimulation was inhibited by 80% or more in the presence of the anti-type 1 IGF receptor antibody α-IR3 and anti-IGF-II antibody. The IGF-II concentrations in the culture media, measured after acidic gel filtration, increased about 1.5-fold and Northern blotting showed a concomitant increase in IGF-II mRNA levels. The mitogenic effect of RA therefore reflects its stimulation of IGF-II production. The availability of IGF-II to the cells may also be enhanced because of the proteolysis of IGFBP-2 to which it is bound. After this initial phase, proliferation ceased despite continued IGF-II production between 24 and 72 h. Both IGFBP-2 and IGFBP-4 production decreased, whereas that of IGFBP-6 increased. These changes appeared both in the protein quantities and in their mRNAs. Insulin-like growth factor binding protein 6 has a strong affinity for IGF-II, 5–10 times that of IGFBP-2 and at least 10 times that of the type 1 IGF receptor, and the arrested proliferation may result, at least in part, from sequestration by IGFBP-6 of the IGF-II secreted. Sylvie Babajko, INSERM U142, Hôpital Saint Antoine, 184 rue du Faubourg, St Antoine, 75571 Paris Cedex 12, France

scholarly journals Retinoic acid regulates insulin-like growth factor-binding protein expression in human osteoblast cells.

Endocrinology ◽  
1996 ◽  
Vol 137 (3) ◽  
pp. 975-983 ◽  
Author(s):  
Y Zhou ◽  
S Mohan ◽  
T A Linkhart ◽  
D J Baylink ◽  
D D Strong
Keyword(s):  
Retinoic Acid ◽  
Growth Factor ◽  
Protein Expression ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Human Osteoblast ◽  
Osteoblast Cells ◽  
Factor Binding

Prenatal treatment with retinoic acid promotes pulmonary alveologenesis in the nitrofen model of congenital diaphragmatic hernia

2008 ◽  
Vol 43 (3) ◽  
pp. 500-507 ◽  
Author(s):  
Sandra Montedonico ◽  
Kaoru Sugimoto ◽  
Patrick Felle ◽  
John Bannigan ◽  
Prem Puri
Keyword(s):  
Retinoic Acid ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Prenatal Treatment

The Effects of Retinoic Acid on the Insulin-like Growth Factor Axis in Primary Tissue Culture from Hyperparathyroidism

2006 ◽  
Vol 30 (5) ◽  
pp. 714-720 ◽  
Author(s):  
Chris K.M. Wong ◽  
Teresa Lai ◽  
Jeffrey M.P. Holly ◽  
Malcolm H. Wheeler ◽  
Claire E.H. Stewart ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Primary Tissue Culture ◽  
Primary Tissue

Retinoic acid regulates insulin-like growth factor II expression in a neuroblastoma cell line.

Endocrinology ◽  
1992 ◽  
Vol 130 (6) ◽  
pp. 3669-3676 ◽  
Author(s):  
K Matsumoto ◽  
C Gaetano ◽  
W H Daughaday ◽  
C J Thiele
Keyword(s):  
Retinoic Acid ◽  
Growth Factor ◽  
Cell Line ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Insulin Like Growth Factor ◽  
Factor Ii

scholarly journals Down-regulation of insulin-like growth factor binding proteins and growth modulation in hepatoma cells by retinoic acid

Hepatology ◽  
1999 ◽  
Vol 29 (4) ◽  
pp. 1091-1098 ◽  
Author(s):  
Dae-Ghon Kim ◽  
Dae-yeol Lee ◽  
Baik-Hwan Cho ◽  
Kyung-Ran You ◽  
Mi-Young Kim ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Growth Factor ◽  
Binding Proteins ◽  
Hepatoma Cells ◽  
Insulin Like Growth Factor ◽  
Growth Modulation ◽  
Down Regulation ◽  
Factor Binding
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