Serum concentrations of the third component of complement in healthy dogs and dogs with protein-losing nephropathy

The structure-relationships and pharmacokinetic properties of the new second- and third-generation cephalosporins are reviewed. The new second-generation cephalosporins include ceforanide, cefotiam, and cefuroxime. The third-generation cephalosporins include cefmenoxime, cefoperazone, cefotaxime, cefsulodin, ceftazidime, ceftizoxime, ceftriaxone, and moxalactam. These new cephalosporins are semisynthetic analogs with different chemical substitutions on a 7-aminocephalosporanic nucleus. As a result of these chemical modifications, improvements in the antibacterial spectrum as well as pharmacokinetic properties have occurred. In general, the new cephalosporins have longer half-lives, higher and prolonged serum concentrations, and increased cerebrospinal fluid penetration. Selected cephalosporins also have increased biliary tract concentrations. A classification scheme for these new agents, based on generation and susceptibility to Pseudomonas aeruginosa, is presented.

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THE BIOLOGIC SIGNIFICANCE OF THE THIRD COMPONENT OF COMPLEMENT (C3) IN NONIMMUNE HOST DEFENSES

Pediatric Research ◽

10.1203/00006450-197404000-00486 ◽

1974 ◽

Vol 8 (4) ◽

pp. 421-421

Author(s):

Jerry A Winkelstein ◽

Mary Ruth Smith ◽

Hyun S Shin ◽

David H Carver

Keyword(s):

Complement C3 ◽

Host Defenses ◽

The Third ◽

Third Component Of Complement

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Defective Activation of the Third Component of Complement in the Sera of Newborn Infants

Pediatric Research ◽

10.1203/00006450-197910000-00001 ◽

1979 ◽

Vol 13 (10) ◽

pp. 1093-1096 ◽

Cited By ~ 12

Author(s):

Jerry A Winkelstein ◽

Lawrence E Kurlandsky ◽

Andrea J Swift

Keyword(s):

Newborn Infants ◽

The Third ◽

Third Component Of Complement

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Systolic blood pressure of dogs at hospital and domestic environment

Ciência Rural ◽

10.1590/s0103-84782012005000036 ◽

2012 ◽

Vol 42 (7) ◽

pp. 1242-1248

Author(s):

Frederico Aécio Carvalho Soares ◽

Elisa Barp Neuwald ◽

Verônica Santos Mombach ◽

Ana Elize Ribeiro D'Avila ◽

Francisco de Oliveira Conrado ◽

...

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

Doppler Ultrasonography ◽

Serum Cortisol ◽

Serum Concentrations ◽

Pathological Conditions ◽

Healthy Dogs ◽

The Mean ◽

Veterinary Hospital ◽

At Home

The measurement of blood pressure (BP) is an important assessment of the cardiovascular system, being influenced by physical and pathological conditions. Certain situations of stress and anxiety during BP measurement can lead to elevated values in small animals, known in medicine as "white coat effect". The aim of this research was to compare systolic blood pressure (SBP) measurement using Doppler ultrasonography in 45 adult healthy dogs in two environments, at a veterinary hospital and at home. Comparison of heart rate, serum concentrations of cortisol and glucose intended to help the evaluation of the stress level of the animals. The mean of SBP at the veterinary hospital was 154.7mmHg and it was significantly (P<0.01) higher than at home (136.3mmHg). It was also observed that HR (mean=122.7bpm), and serum cortisol (median=4.5µg dL-1) and glucose (mean=95.9mg dL-1) concentrations were significantly higher (P<0.01) at the hospital, when compared with values obtained at home (109.6bpm; 1.5µg dL-1 and 85.5mg dL-1, respectively). In conclusion, the environment can influence SBP in dogs, due to factors related to stress.

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