Effects of Imipramine and Methylphenidate on Perceptual-Motor Performance of Hyperactive Children

1976 ◽  
Vol 43 (2) ◽  
pp. 459-470 ◽  
Author(s):  
Carl Spring ◽  
Absalom M. Yellin ◽  
Lawrence Greenberg
Keyword(s):  
Discriminant Function ◽  
Motor Performance ◽  
Digit Span ◽  
Double Blind Study ◽  
Normal Children ◽  
Double Blind ◽  
Hyperactive Children ◽  
Perceptual Motor Performance ◽  
Improved Performance ◽  
Motor Effects

Perceptual-motor effects of imipramine and methylphenidate were evaluated in a double-blind study of 47 hyperactive children. No effects were found for imipramine, although methylphenidate improved performance on several tests. Improvement due to methylphenidate was not related to baseline scores. A discriminant function was computed to compare baseline perceptual-motor scores of the hyperactive and 41 normal children. Only half of the hyperactive children were clearly discriminated from normal children by the discriminant function. The digit-span test, which was not sensitive to methylphenidate, effectively discriminated hyperactive from normal children.

Motor Performance in Hyperactive Children Treated with Imipramine

1988 ◽  
Vol 66 (3) ◽  
pp. 763-769 ◽  
Author(s):  
C. Thomas Gualtieri ◽  
Randall W. Evans
Keyword(s):  
Motor Performance ◽  
Drug Effects ◽  
Tricyclic Antidepressant ◽  
Motor Speed ◽  
Double Blind ◽  
Hyperactive Behavior ◽  
Hyperactivity Disorder ◽  
Hyperactive Children ◽  
Antidepressant Imipramine ◽  
High Doses

The effects of the tricyclic antidepressant imipramine were evaluated in a study of 9 children with Attention Deficit-Hyperactivity Disorder. The study was double-blind, placebo-controlled, with three drug conditions, low, medium, and high doses. The focus was on neuropsychological drug effects. Imipramine exerted negative dose-response effects on motor performance (motor speed, motor pursuit), while it improved hyperactive behavior and attention and raised the heart rate slightly.

Effects of Methylphenidate in Normal Adults with Reference to Drug Action in Hyperactivity

1984 ◽  
Vol 18 (1) ◽  
pp. 86-88 ◽  
Author(s):  
Michael G. Aman ◽  
Marina Vamos ◽  
John S. Werry
Keyword(s):  
Drug Effects ◽  
Drug Action ◽  
Stimulant Drug ◽  
Normal Children ◽  
Double Blind ◽  
Hyperactive Children ◽  
Reduced Physical Activity ◽  
Emotional Responsivity ◽  
Adult Volunteers ◽  
Normal Adults

Methylphenidate was administered to each of 12 adult volunteers in a double-blind, placebo-controlled, crossover study for purposes of comparison with previous studies in hyperactive children. Statistically significant changes occurred only on a minority of measures, but the results were generally in the direction of facilitated performance, reduced physical activity and increased emotional responsivity. As these results are similar to those in hyperactive and normal children, this appears to support the contention that stimulant drug effects in hyperactive children are not paradoxical or atypical.

Effects of Clinical Dosage Levels of Methylphenidate on Two-Flash Thresholds and Perceptual Motor Performance in Hyperactive Children

1979 ◽  
Vol 48 (3) ◽  
pp. 721-722 ◽  
Author(s):  
Norman G. Gordon ◽  
Donald R. Kantor
Keyword(s):  
Motor Performance ◽  
Digit Symbol ◽  
Motor Tasks ◽  
Hyperactive Children ◽  
Perceptual Motor Performance ◽  
Normal Controls

Three groups ( ns = 10) of children (normals, hyperactives, hyperactives on medication) were administered eight perceptual-motor tasks. The normal controls were significantly superior in performance in comparison with the hyperactives taken off methylphenidate on three tasks but only superior on one task (Digit Symbol) when compared to hyperactives on methylphenidate. The hyperactives on medication were also significantly superior to the hyperactives not on medication on the Digit Symbol task.

Effect of pomegranate fruit supplementation on performance and various markers in athletes and active subjects: a systematic review

2019 ◽  
pp. 1-15
Author(s):  
Alicja Urbaniak ◽  
Anna Skarpańska-Stejnborn
Keyword(s):  
Vessel Diameter ◽  
Whole Body ◽  
Double Blind Study ◽  
Double Blind ◽  
Physically Active ◽  
Highly Active ◽  
Body Strength ◽  
Rate Of Increase ◽  
Study Designs ◽  
Pomegranate Fruit

Abstract. The aim of the study was to review recent findings on the use of POM supplements in athletes of various disciplines and physically active participants. Eleven articles published between 2010 and 2018 were included, where the total number of investigated subjects was 176. Male participants constituted the majority of the group (n = 155), as compared to females (n = 21). 45% of research described was conducted on athletes, whereas the remaining studies were based on highly active participants. Randomised, crossover, double-blind study designs constituted the majority of the experimental designs used. POM supplementation varied in terms of form (pills/juice), dosage (50 ml–500 ml) and time of intervention (7 days–2 months) between studies. Among the reviewed articles, POM supplementation had an effect on the improvement of the following: whole body strength; feeling of vitality; acute and delayed muscle fatigue and soreness; increase in vessel diameter; blood flow and serum level of TAC; reduction in the rate of increase for HR, SBP, CK and LDH; support in the recovery of post-training CK, LDH, CRP and ASAT to their baseline levels; reduction of MMP2, MMP9, hsCRP and MDA; and increased activity of antioxidant enzymes (glutathione peroxidase and superoxide dismutase). In the majority of reviewed articles POM supplementation had a positive effect on a variety of parameters studied and the authors recommended it as a supplement for athletes and physically active bodies.

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