scholarly journals The Efficiency of Pulse Therapy with Glucocorticoids in Inflammatory Orbital Disorders: Case Report

2020 ◽  
Vol 25 (4) ◽  
pp. 22-24
Author(s):  
Ioana-Codruţa Lebădă ◽  
Mihaela Stanciu
Keyword(s):  
Case Report ◽  
Thyroid Dysfunction ◽  
Clinical Presentation ◽  
Pulse Therapy ◽  
Inflammatory Disorder ◽  
Orbital Pseudotumor ◽  
Ocular Symptoms ◽  
Receptor Antibodies ◽  
Symptoms And Signs ◽  
Tsh Receptor Antibodies

Abstract Orbital pseudotumor represents a benign inflammatory disorder of the orbit, with unspecified etiology, whose clinical presentation can mimic the ocular pathology of Basedow disease, namely Graves’ ophthalmopathy, the two of them representing two of the most common orbital conditions. Imagistic methods and laboratory analyses can establish the diagnosis through orbital MRI images specific for the orbital pseudotumor, especially by dosage of the TSH receptor antibodies (TRAb) which will have increased values in Basedow disease with ocular damage. In both situations, the treatment is represented as a first therapeutic line by administration of corticotherapy in high dosage orally or intravenously, with favorably evolution, which is also observable in the case of our patient who was diagnosed with orbital pseudotumor based on MRI images, with associated thyroid dysfunction with negative TRAb, in which the pulse therapy with Solumedrol has determined the improvement of ocular symptoms and signs.

The role of thyrotropin receptor antibodies in Grave’s Ophthalmopathy treatment

2016 ◽  
Vol 62 (5) ◽  
pp. 54-55
Author(s):  
Narine S. Martirosian ◽  
Nina A. Petunina ◽  
Liubov V. Trukhina
Keyword(s):  
Disease Management ◽  
Therapy Monitoring ◽  
Clinical Manifestations ◽  
Pulse Therapy ◽  
Clinical Activity ◽  
Inflammatory Disorder ◽  
Intravenous Methylprednisolone ◽  
Thyrotropin Receptor Antibodies ◽  
Receptor Antibodies

Background. Graves' ophthalmopathy (GO) is an autoimmune inflammatory disorder affecting the retroorbital tissues. Although the role of TRAb in GO is now accepted by many researchers and clinicians, their use in the disease management of GO is less well studied than the role of TRAb for the diagnosis and therapy monitoring of Graves’ disease.Aim: to evaluate the relation between TRAb level and the activity of GO, the course of GO and the effectiveness of the treatment.Materials and methods. We have studied 26 patients with GO and Grave’s Disease. Activity of GO was measured with the clinical activity score (CAS), we defined active GO as a CAS≥3. TSH, FT4 and TRAb were evaluated. All patients had received intravenous methylprednisolone (ivMP) pulse therapy in cumulative dose 6000 mg. We observed patients for 1 year after pulse therapy. TRAb level was evaluated before, 3, 6 and 12 months after pulse therapy.Results: At the time of initial treatment all patients had active GO, 60% with CAS 3-4 and 40% with CAS 5-7. On year after the pulse therapy of GO, all patients were classified into responders (69,2%) and non-responders (30,8%) according to their clinical manifestations. Pulse therapy considered as effective if GO activity decreased with CAS ≤ 2. Serum TRAb level was significantly higher in patients who non-responded to therapy – 34,8 U/L vs 17,5 U/L (p≤0,01). This level was significantly decreased in patients responded to treatment – 1,6 U/L vs 12,4 U/L (p≤0,01). TRAb level above 28,8 U/L before treatment (p≤0,01), 10,1 U/L after 3 months of treatment (p≤0,01), 5,1 U/L after 6 months of treatment (p≤0,01) and 8,2 U/L after 3 months of treatment (p≤0.01) was associated with higher risk of non-responding.Conclusion: We conclude, that TRAb level may serve not only as predictor of GO activity and severity, but changes in the level of antibodies could be of additional help for the disease management with ivMP.

scholarly journals Marked Mydriasis and Neuritis Nervi Optici Associated with Galactorrhea Following Citalopram Treatment: A Case Report and Discussion

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Horst J. Koch ◽  
Heike Zellmer
Keyword(s):  
Case Report ◽  
Major Depression ◽  
Clinical Laboratory ◽  
Pulse Therapy ◽  
Neuritis Nervi Optici ◽  
Ocular Symptoms ◽  
Methyl Prednisolone

We report the case of a 25-year-old women suffering from major depression who was treated with citalopram for several weeks with doses between 20 mg and 60 mg. She gradually developed marked mydriasis within 2 months after treatment and subsequently neuritis nervi optici. Moreover, abrupt galactorrhea occurred after 2 months of treatment. All neuro-ophthalmological, neurophysiological, clinical laboratory, and neuroradiological diagnostic efforts did not reveal an underlying organic pathophysiology. The ocular symptoms disappeared rapidly after the discontinuation of citalopram and pulse therapy with methyl-prednisolone. However, galactorrhea persisted for a few weeks necessitating treatment with bromocriptine.

scholarly journals Pigmented Oral Lichen Planus: A Case Report

2017 ◽  
Vol 1 (1) ◽  
pp. 11
Author(s):  
Firstine Kelsi Hartanto ◽  
Thomas George Kallarakal
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Diagnostic Process ◽  
Clinical Feature ◽  
Inflammatory Disorder ◽  
Predisposing Factor ◽  
Oral Lichen

<p><strong>Background:</strong> Lichen planus is a chronic muccocutaneous inflammatory disorder. Oral lichen planus (OLP) has certain specific characteristics in its clinical presentation, but can also be presented in forms resembling other diseases. This may introduce difficulty in the diagnostic process. It has been reported that OLP affects between 0.1 to 4% individuals, predominantly women and people over 40 years old. <strong>Case Report:</strong> A 46-year-old woman complained of a non-healing ulcer present for 1.5 months. Intraorally, multiple white striae with prominent central areas of brownish hyperpigmentation were apparent on the right and left buccal mucosa, right and left buccal sulcus, and lateral and dorsum of the tongue. A biopsy was completed and the histopathology features confirmed the diagnosis of OLP. For the initial treatment, a topical corticosteroid was prescribed, followed by steroid mouthwash. Response to this treatment was positive. OLP has been frequently reported to affect women over the age of 40, with psychological stress as a primary predisposing factor. The clinical presentation is characteristic of Wickham’s striae with erosive areas. However, a biopsy and histopathological examination is mandatory to confirm the diagnosis. The clinical feature of pigmented OLP has been reported and confirmed by microscopic finding of band-like lymphocytic appearance which is the pathognomonic features of OLP, along with basal cell liquefaction degeneration, and melanin in continence at the lamina propria. <strong>Conclusion:</strong> Pigmented OLP is a variant of erosive OLP. Anamnesis, clinical presentation, and histopathological examination confirm diagnosis.</p>

scholarly journals Induction of Autoimmune Hypothyroidism and Subsequent Hyperthyroidism by TSH Receptor Antibodies following Subacute Thyroiditis: A Case Report.

2001 ◽  
Vol 48 (2) ◽  
pp. 139-142 ◽  
Author(s):  
MAKOTO IITAKA ◽  
SACHIKO KAKINUMA ◽  
KAYO YAMANAKA ◽  
SATOMI FUJIMAKI ◽  
IKUROU OOSUGA ◽  
...  
Keyword(s):  
Case Report ◽  
Subacute Thyroiditis ◽  
Tsh Receptor ◽  
Autoimmune Hypothyroidism ◽  
Receptor Antibodies ◽  
Tsh Receptor Antibodies

scholarly journals Cerebellar haemangioblastoma presenting with dizziness in pregnancy: case report and review of the literature

2009 ◽  
Vol 2 (4) ◽  
pp. 164-167 ◽  
Author(s):  
Anna P Kenyon ◽  
Salman Haider ◽  
Keyoumars Ashkan ◽  
Catherine Nelson-Piercy
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Medical Literature ◽  
Clinical Presentation ◽  
Review Of The Literature ◽  
Cerebellar Haemangioblastoma ◽  
Symptoms And Signs ◽  
Cerebral Neoplasms ◽  
In Pregnancy ◽  
New Onset

Cerebral neoplasms are uncommon in pregnancy but should be considered in any pregnant woman with new onset neurological symptoms and signs. We report a case of cerebellar haemangioblastoma presenting in pregnancy and discuss the clinical presentation, diagnosis, surgical management and medical literature surrounding the condition.

Fluctuating Thyroid Function Depending on the Balance between Stimulating and Blocking Types of TSH Receptor Antibodies: A Case Report

Thyroid ◽  
1993 ◽  
Vol 3 (4) ◽  
pp. 315-318 ◽  
Author(s):  
KANJI KASAGI ◽  
AKINARI HIDAKA ◽  
KEIGO ENDO ◽  
SHINICHI MIYAMOTO ◽  
RYO TAKEUCHI ◽  
...  
Keyword(s):  
Case Report ◽  
Thyroid Function ◽  
Tsh Receptor ◽  
Receptor Antibodies ◽  
Tsh Receptor Antibodies

Orbital Pseudotumor with Extraorbital Extension in Childhood - A Case Report and Review of Literature

2015 ◽  
Vol 76 (S 02) ◽  
Author(s):  
Anes Mašović ◽  
Ibrahim Omerhodžić ◽  
Emina Hrvat ◽  
Lejla Gurbeta ◽  
Edin Begić ◽  
...  
Keyword(s):  
Case Report ◽  
Review Of Literature ◽  
Orbital Pseudotumor

Bi-microbial Healthcare-Associate Endocarditis caused by Enterococcus faecalis and Burkholderia cepacia: A Case Report and literature review

2020 ◽  
Vol 02 ◽  
Author(s):  
Masood Ghori ◽  
Nadya O. Al Matrooshi ◽  
Samir Al Jabbari ◽  
Ahmed Bafadel ◽  
Gopal Bhatnagar
Keyword(s):  
Case Report ◽  
Infective Endocarditis ◽  
Literature Review ◽  
Enterococcus Faecalis ◽  
Surgical Management ◽  
Burkholderia Cepacia ◽  
Clinical Presentation ◽  
Complicated Course ◽  
Healthcare Associated ◽  
Echocardiographic Findings

: Infective Endocarditis (IE), a known complication of hemodialysis (HD), has recently been categorized as Healthcare-Associated Infective Endocarditis (HAIE). Single pathogen bacteremia is common, polymicrobial endocardial infection is rare in this cohort of the patients. We report a case of endocarditis caused by Enterococcus faecalis (E. faecalis) and Burkholderia cepacia (B. cepacia), a first ever reported combination of a usual and an unusual organism, respectively, in a patient on HD. Clinical presentation of the patient, its complicated course ,medical and surgical management ,along with microbial and echocardiographic findings is presented herein. The authors believe that presentation of this case of HAIE may benefit and contribute positively to cardiac science owing to the rare encounter of this organism as a pathogen in infective endocarditis and the difficulties in treating it.

Surgical management of choke through oesophagotomy in a buffalo: A case report

2017 ◽  
Vol 12 (3) ◽  
Author(s):  
Devasee Borakhatariya ◽  
A. B. Gadara
Keyword(s):  
Case Report ◽  
Surgical Management ◽  
Clinical Presentation ◽  
Clinical Signs ◽  
Thoracic Inlet ◽  
Cervical Oesophagus ◽  
Foreign Objects ◽  
History Of ◽  
Oesophageal Obstruction ◽  
Large Animals

Oesophageal disorders are relatively uncommon in large animals. Oesophageal obstruction is the most frequently encountered clinical presentation in bovine and it may be intraluminal or extra luminal (Haven, 1990). Intraluminal obstruction or “choke” is the most common abnormality that usually occurs when foreign objects, large feedstuff, medicated boluses, trichobezoars, or oesophageal granuloma lodge in the lumen of the oesophagus. Oesophageal obstructions in bovine commonly occur at the pharynx, the cranial aspect of the cervical oesophagus, the thoracic inlet, or the base of the heart (Choudhary et al., 2010). Diagnosis of such problem depends on the history of eating particular foodstuff and clinical signs as bloat, tenesmus, retching, and salivation

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