Determination of risperidone at picogram level in human urine by luminol—H2O2 chemiluminescence

2006 ◽  
Vol 60 (4) ◽  
Author(s):  
X. Xie ◽  
X. Shao ◽  
Z. Song
Keyword(s):  
Flow Injection ◽  
Human Urine ◽  
High Sensitivity ◽  
Chemiluminescence Method ◽  
Synergistic Enhancement ◽  
Relative Standard ◽  
Sensitive Determination ◽  
Flow Injection Chemiluminescence ◽  
Simple Flow

AbstractA simple flow-injection chemiluminescence method with synergistic enhancement has been investigated for the rapid and sensitive determination of antipsychotic risperidone. The synergistic action was significant in the chemiluminescence system of luminol—hydrogen peroxide with risperidone as an enhancer. The increased chemiluminescence intensity was correlated with risperidone concentration within the range from 10 pg mL−1 to 1.0 ng mL−1 with relative standard deviations lower than 5.0 % and the detection limit of 4 pg mL−1. At a flow rate of 2.0 mL min−1, the flow-injection chemiluminescence method exhibited both a high sensitivity and excellent selectivity giving a throughput of 120 times per hour. The proposed method was successfully applied to determine the risperidone content in human urine without any pretreatment. It was found that the excretive amounts of risperidone reached their maximum after taking 2.0 mg of risperidone for 1 h, with a total excretive ratio of 17.37 % in 8.5 h.

The Determination of Perphenazine by a New Simple Flow‐Injection Chemiluminescence Method

2005 ◽  
Vol 38 (12) ◽  
pp. 1933-1941 ◽  
Author(s):  
Xiaonian Han ◽  
Yuhai Tang ◽  
Chunling Yu ◽  
Xiaohui Zheng ◽  
Qingju Jin
Keyword(s):  
Flow Injection ◽  
Chemiluminescence Method ◽  
Flow Injection Chemiluminescence ◽  
Simple Flow

scholarly journals Evaluation of Antibacterial Enrofloxacin in Eggs by Matrix Solid Phase Dispersion-Flow Injection Chemiluminescence

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Xiaocui Duan ◽  
Pingping Zhang ◽  
Jing Feng ◽  
Ning Jiao
Keyword(s):  
Flow Injection ◽  
Solid Phase ◽  
Optimal Conditions ◽  
Testing Technique ◽  
Matrix Solid Phase Dispersion ◽  
Phase Dispersion ◽  
Relative Standard ◽  
Flow Injection Chemiluminescence ◽  
Simple Flow

The study based on the chemiluminescence (CL) reaction of potassium ferricyanide and luminol in sodium hydroxide medium, enrofloxacin (ENRO) could dramatically enhance CL intensities and incorporated with matrix solid-phase dispersion (MSPD) technique (Florisil used as dispersant, dichloromethane eluted the target compounds). A simple flow injection chemiluminescence (FL-CL) method with MSPD technique for determination of ENRO in eggs was described. Under optimal conditions, the CL intensities were linearly related to ENRO concentration ranging from4.0×10-8 g.L−1to5.0×10-5 g.L−1, with a correlation coefficient of 0.9989 and detection limit of5.0×10-9 g.L−1. The relative standard deviation was 3.6% at an ENRO concentration of2.0×10-6 g.L−1. Our testing technique can help ensure food safety, and thus, protect public health.

Flow-Injection Chemiluminescence Method for the Determination of Hydrocortisone and Progesterone

1997 ◽  
Vol 51 (10) ◽  
pp. 1484-1487 ◽  
Author(s):  
Huai-Na Li ◽  
Yun-Xing Ci
Keyword(s):  
Sulfuric Acid ◽  
Reaction Mechanism ◽  
Flow Injection ◽  
Chemiluminescence Method ◽  
Experimental Conditions ◽  
Mercapto Group ◽  
Sensitizing Effect ◽  
Flow Injection Chemiluminescence ◽  
Simple Flow

A simple flow injection chemiluminescence (CL) method for the determination of progesterone and hydrocortisones (HCRs) is described. The method is based on their sensitizing effect on the chemiluminescence reaction of a mercapto-group (-SH) with cerium(IV) in sulfuric acid. This method allows determination in the ranges 0.28–8.0 μg/mL for hydrocortisones (HCRs) and 0.5–8.0 μg/mL for progesterone with a detection limit of 0.10 μg/mL for HCRs and 0.26 μg/mL for progesterone. The experimental conditions for the reaction are optimized. The possible reaction mechanism is discussed.

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