Ethambutol Optic Neuropathy Visual Function And Visual Evoked Potentials

Inflammatory optic neuropathy (ON) is a rare event in Behçet’s disease (BD). We report herein a series of ten BD Tunisian patients with ON and describe its clinical features among them. A retrospective review of BD patients (International Study Group for BD criteria) was performed. The patients were divided into two groups: those presenting an inflammatory ON, and those none. The diagnosis of inflammatory ON was based on the clinical examination, visual field and visual evoked potentials. We analyzed the characteristics of the two groups. Ten patients (2.3%) presented an inflammatory ON among our 440 patients. Inflammatory ON was inaugural in 8 cases. Clinical manifestations were as follows: blurred vision (7 cases) and periorbital pain (3 cases). In two cases, the patients did not complain from ophthalmological symptoms. The fundus revealed a papilledema (2 cases), papillary pallor (4 cases), and was normal in 5 cases. Visual field realized in only three patients showed a scotoma in all cases. Visual evoked potentials revealed increased latency in all cases. All patients received corticosteroids associated to an immunosuppressive agent. The comparative study between the two groups revealed that inflammatory ON was significantly more associated to neurological involvement (p<0.0001) and that the disease was more severe in the ON group (p<0.0001). Inflammatory ON in BD is rare and may occur at an early stage of the clinical course of the disease. Its prevalence is certainly underestimated. A systematic visual evoked potential may be interesting as a screening tool.

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Visual evoked potentials in veterinary ophthalmology: literature review

Russian veterinary journal ◽

10.32416/article_5d935e18017700.96578341 ◽

2019 ◽

Vol 2019 (5) ◽

pp. 23-29

Author(s):

Артем Миронович ◽

Artem Mironovich ◽

Сергей Бояринов ◽

Sergey Boyarinov

Keyword(s):

Nervous System ◽

Literature Review ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Visual Function ◽

Research Method ◽

Structural Changes ◽

Complete Loss ◽

Diagnostic Research ◽

Visual Evoked

Diagnosis of causes of blindness in veterinary ophthalmology is an urgent issue. There are a large number of diseases of central and peripheral nervous system, which can lead to partial or complete loss of visual function in animals. Visual evoked potentials (VEP) of brain can be a reliable diagnostic research method to clarify the location of the disfunction and causes of blindness in dogs and cats. Together, the visual evoked potentials and electroretinography complement each other and give a greater idea of electrophysiology of visual process. In this article on the basis of large quantity of information we examine the ways of applying this method and the problems, connected with its use. It is important to understand that the VEP can reveal the functional disturbances of visual way, but does not give the information about the structural changes.

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Visual evoked potentials in diagnostics of optic neuropathy associated with renal failure

Postępy Higieny i Medycyny Doświadczalnej ◽

10.5604/01.3001.0010.3787 ◽

2017 ◽

Vol 71 (0) ◽

pp. 32-39 ◽

Cited By ~ 1

Author(s):

Małgorzata Jurys ◽

Sebastian Sirek ◽

Aureliusz Kolonko ◽

Dorota Pojda-Wilczek

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Optic Neuropathy ◽

Neurological Complications ◽

Noninvasive Technique ◽

Secondary Demyelination ◽

P100 Component ◽

Visual Evoked

Chronic renal failure is associated with many neurological complications. Due to accumulation of uremic neurotoxins axonal degeneration with its secondary demyelination occurs, which results in development of polineuropathy in 60-100% of patients with chronic renal failure. One of the most severe peripheral neuropathy is optic neuropathy. It is associated with visual deterioration and reduction in quality of life. Symptoms of the optic neuropathy may appear either before or after dialysis therapy. They often worsen after renal transplant, probably due to immunosuppressive regimen. Early diagnostics of the optic neuropathy became possible by using visual evoked potentials (VEP). This reliable, sensitive and noninvasive technique provides a direct measure of subclinical impairment of visual pathways. Among hemodialysed or immunosupressed patients one can observe abnormal VEP parameters – especially prolonged latency of the P100 component, less often fluctuation of its amplitude. These alterations are pronounced even if clinical examination reveals no abnormalities. This review presents a summary of current use of visual evoked potentials in monitoring of patients with chronic renal failure.

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