The L-type voltage-gated calcium channel CaV1.2 α1 subunit in activated reactive astrocytes around β-amyloid plaques in an Alzheimer mouse model

2013 ◽  
Vol 1 (Suppl. 1) ◽  
pp. A2.1
Author(s):  
Nina Daschil
Keyword(s):  
Mouse Model ◽  
Calcium Channel ◽  
Amyloid Plaques ◽  
Reactive Astrocytes ◽  
Voltage Gated ◽  
Β Amyloid ◽  
Voltage Gated Calcium Channel ◽  
Α1 Subunit

Alterations in hippocampal voltage-gated calcium channel α1 subunit expression patterns after kainate-induced status epilepticus in aging rats

2003 ◽  
Vol 57 (1) ◽  
pp. 15-32 ◽  
Author(s):  
Kevin M. Kelly ◽  
Milos D. Ikonomovic ◽  
Eric E. Abrahamson ◽  
Elena A. Kharlamov ◽  
Teresa M. Hentosz ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Calcium Channel ◽  
Expression Patterns ◽  
Aging Rats ◽  
Voltage Gated ◽  
Subunit Expression ◽  
Voltage Gated Calcium Channel ◽  
Α1 Subunit

scholarly journals straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel α1 subunit

2008 ◽  
Vol 181 (1) ◽  
pp. 157-170 ◽  
Author(s):  
Cindy V. Ly ◽  
Chi-Kuang Yao ◽  
Patrik Verstreken ◽  
Tomoko Ohyama ◽  
Hugo J. Bellen
Keyword(s):  
Calcium Channel ◽  
Neuronal Excitability ◽  
Neuromuscular Junctions ◽  
Synaptic Function ◽  
Voltage Gated ◽  
Α2δ Subunit ◽  
Voltage Gated Calcium Channel ◽  
Α1 Subunit ◽  
Synaptic Level ◽  
Synaptic Stabilization

In a screen to identify genes involved in synaptic function, we isolated mutations in Drosophila melanogaster straightjacket (stj), an α2δ subunit of the voltage-gated calcium channel. stj mutant photoreceptors develop normal synaptic connections but display reduced “on–off” transients in electroretinogram recordings, indicating a failure to evoke postsynaptic responses and, thus, a defect in neurotransmission. stj is expressed in neurons but excluded from glia. Mutants exhibit endogenous seizure-like activity, indicating altered neuronal excitability. However, at the synaptic level, stj larval neuromuscular junctions exhibit approximately fourfold reduction in synaptic release compared with controls stemming from a reduced release probability at these synapses. These defects likely stem from destabilization of Cacophony (Cac), the primary presynaptic α1 subunit in D. melanogaster. Interestingly, neuronal overexpression of cac partially rescues the viability and physiological defects in stj mutants, indicating a role for the α2δ Ca2+ channel subunit in mediating the proper localization of an α1 subunit at synapses.

Comparative genomics of the human and Fugu voltage-gated calcium channel α1-subunit gene family reveals greater diversity in Fugu

Gene ◽  
2006 ◽  
Vol 366 (1) ◽  
pp. 117-127 ◽  
Author(s):  
Esther Wong ◽  
Wei-Ping Yu ◽  
Wai Ho Yap ◽  
Byrappa Venkatesh ◽  
Tuck Wah Soong
Keyword(s):  
Comparative Genomics ◽  
Calcium Channel ◽  
Gene Family ◽  
Subunit Gene ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
Α1 Subunit

scholarly journals A novel mouse model of the aged brain: Over-expression of the L-type voltage-gated calcium channel Ca V 1.3

2017 ◽  
Vol 322 ◽  
pp. 241-249 ◽  
Author(s):  
Jamie N. Krueger ◽  
Shannon J. Moore ◽  
Rachel Parent ◽  
Brandon C. McKinney ◽  
Amy Lee ◽  
...  
Keyword(s):  
Mouse Model ◽  
Calcium Channel ◽  
Over Expression ◽  
Voltage Gated ◽  
Aged Brain ◽  
Voltage Gated Calcium Channel
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