scholarly journals Association between obstructive sleep apnea and metabolic syndrome: a meta-analysis

2016 ◽  
Vol 39 (5) ◽  
pp. 161 ◽  
Author(s):  
De-Lei Kong ◽  
Zheng Qin ◽  
Wei Wang ◽  
Ying Pan ◽  
Jian Kang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Standard Mean Difference ◽  
Obstructive Sleep

Purpose: Evidence suggests that obstructive sleep apnea (OSA) is related to metabolic syndrome; however, the relationship among metabolic syndrome parameters (blood pressure, fasting blood glucose (FBG), high density lipoprotein (HDL) and low density lipoprotein (LDL)) and OSA is unclear. Methods: PRISMA guidelines were followed for this study. Medline, Cochrane, EMBASE and Google Scholar databases were searched until December 23, 2015, using following terms: obstructive sleep apnea, sleep apnea, OSA and metabolic syndrome. Results: Ten studies were included in the analysis which included 2053 patients. Patients with OSA had higher systolic blood pressure (SBP) (pooled standard mean difference (SMD) = 0.56, 95% CI, 0.40 to 0.71, P

scholarly journals Adipose tissue dysfunction markers in obese patients with obstructive sleep apnea syndrome

2015 ◽  
Vol 96 (2) ◽  
pp. 134-137
Author(s):  
A V Yakovlev ◽  
S D Mayanskaya ◽  
A N Vergazova ◽  
L P Plutalova ◽  
P B Mazina ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Low Density Lipoprotein ◽  
Sleep Apnea Syndrome ◽  
Density Lipoprotein ◽  
Low Density ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Aim. To examine the relationship between obstructive sleep apnea syndrome and metabolic dysfunction in obese patients.Methods. The study included 66 male patients aged 53±5.11 years with previously diagnosed obstructive sleep apnea syndrome and obesity (body mass index ≥30 kg/m2). Cardiorespiratory monitoring, 24-hour blood pressure monitoring was performed in all patients; low density lipoprotein, triglycerides, high density lipoprotein, total cholesterol and glucose blood levels, as well as adiponectin and leptin blood concentrations were measured in all patients.Results. Blood pressure level and leptin blood concentration were significantly higher in patients with severe form of obstructive sleep apnea syndrome. There was no statistically significant relationship found between the lipid profile parameters and other adipokines and the severity of obstructive sleep apnea syndrome. The data analysis also revealed association between the elevated levels of leptin and the classic cardiovascular risk factors - arterial hypertension and low density lipoprotein level.Conclusion. The revealed associations may indicate the additional role of leptin as the biochemical marker of early development of obstructive breathing sleep disorders in patients with abdominal obesity, as well as the early manifestation of other components of metabolic syndrome - arterial hypertension and dyslipidemia with concomitant significant increase in cardiovascular risk.

Effect of Adenotonsillectomy on Blood Pressure in Children with Obstructive Sleep Apnea: A Meta-Analysis

2021 ◽  
Author(s):  
Kun-Tai Kang ◽  
Shuenn-Nan Chiu ◽  
Chia-Hsuan Lee ◽  
Ming-Tzer Lin ◽  
Wei-Chung Hsu
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Meta Analysis ◽  
Obstructive Sleep

Association between obstructive sleep apnea and metabolic abnormalities in patients with hypertrophic cardiomyopathy

2021 ◽  
Author(s):  
Juan Wang ◽  
Haobo Xu ◽  
Jiansong Yuan ◽  
Chao Guo ◽  
Fenghuan Hu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Hypertrophic Cardiomyopathy ◽  
High Density Lipoprotein ◽  
Fasting Glucose ◽  
Density Lipoprotein ◽  
Metabolic Abnormalities ◽  
Obstructive Sleep

Abstract Objectives Metabolic abnormalities have been associated with long-term cardiac mortality in patients with hypertrophic cardiomyopathy (HCM). Obstructive sleep apnea (OSA) is a risk factor for metabolic abnormalities in general populations, but association between OSA and metabolic abnormalities in HCM is still undefined. This study aimed to investigate the relationship between OSA and metabolic dysfunction in a large series of patients with HCM. Methods A total of 587 patients with HCM who underwent sleep evaluations at Fuwai Hospital were included. Data from clinical characteristics, polysomnography studies and metabolic measurements were collected. Results OSA was present in 344 patients (58.6%). Patients with OSA were older, more often male and had more clinical comorbidities. Body mass index, blood pressure, fasting glucose and triglycerides all increased (all P<0.001) and high-density lipoprotein cholesterol decreased (P=0.046) with the severity of OSA. In multivariate analysis, moderate to severe OSA and Log (AHI[apnea-hypopnea index]+1) were independently associated with obesity (OR, 2.42; 95%CI [1.48–3.95] and OR, 1.60; 95%CI [1.31–1.95]), elevated blood pressure (OR, 1.99; 95%CI [1.42–3.26] and OR, 1.31; 95%CI [1.08–1.60]) and elevated triglycerides (OR, 1.71; 95%CI [1.05–2.78] and OR, 1.24; 95%CI [1.02–1.51] but not elevated fasting glucose (OR, 0.88; 95%CI [0.50–1.52] and OR, 1.02; 95%CI [0.82–1.28]) and reduced high-density lipoprotein cholesterol (OR, 1.30; 95%CI [0.83–2.04] and OR, 1.06; 95%CI [0.89–1.27]). Conclusions Severity of OSA is independently associated with some profiles of metabolic abnormalities. Clinical trials are required to determine whether OSA treatment improves metabolic abnormalities and long-term outcomes in patients with HCM.

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