scholarly journals Carotid Intima-Media Thickness in Patients with Subclinical Hypothyroidism: A Prospective Controlled Study

2021 ◽  
Vol 44 (4) ◽  
pp. E39-45
Author(s):  
Anally J. Soto-García ◽  
Guillermo Elizondo-Riojas ◽  
Rene Rodriguez-Gutiérrez ◽  
Leonardo G. Mancillas-Adame ◽  
J. Gerardo González-González
Keyword(s):  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Subclinical Hypothyroidism ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Controlled Study ◽  
Overt Hypothyroidism ◽  
Media Thickness

Purpose: The association between subclinical hypothyroidism (SCH) and cardiovascular risk, particularly with a TSH <10 µIU/ml, remains controversial. The objective of our study was to assess the association between SCH and cardiovascular risk through carotid intima-media thickness, and alternatively, to evaluate its change after treatment with levothyroxine. Methods: A total of 54 individuals were included in the study: 18 with SCH; 18 with overt hypothyroidism (OH); and 18 healthy controls (HC). The carotid intima-media thickness was measured in each group. In SCH, follow-up was performed at three and six months after the start of levothyroxine treatment. Results: The mean age of the total population at baseline was 35.8 years. The median TSH in SCH was 6.15 µIU/ml. The carotid intima-media thickness (mean and standard deviation) was greater in SCH in comparison to the HC group: right common carotid artery (RCCA), 0.486 ± 0.106 mm and 0.413 ± 0.075 mm in SCH and HC, respectively, p=0.01 and left common carotid artery (LCCA), 0.511 ± 0.144 mm and 0.427 mm ± 0.090 in SCH and HC, respectively, p=0.03). In patients with SCH, there was a decrease in the carotid intima-media thickness after treatment with levothyroxine (RCCA and LCCA, p <0.05 at three and six months). Conclusions: There was an association between increased carotid intima-media thickness in patients with SCH in comparison with HC, even with a TSH <10 µIU/ml. The increase was reversed with levothyroxine therapy. The association of this increased thickness with important cardiovascular outcomes remains uncertain and should be evaluated in future studies.

scholarly journals Carotid intima-media thickness in patients with subclinical hypothyroidism: A prospective controlled study

2020 ◽  
Author(s):  
Anally Soto-García ◽  
Guillermo Elizondo-Riojas ◽  
Rene Rodriguez-Gutiérrez ◽  
Leonardo Mancillas-Adame ◽  
Jose Gerardo Gonzalez-Gonzalez
Keyword(s):  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Subclinical Hypothyroidism ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Controlled Study ◽  
Overt Hypothyroidism ◽  
Media Thickness

Background: The association between subclinical hypothyroidism (SCH) and cardiovascular risk, particularly with a TSH <10µIU/ml, remains controversial. The objective of our study was to assess the association between SCH and cardiovascular risk through carotid intima-media thickness, and alternatively, to evaluate its change after treatment with levothyroxine. Methods: A total of 54 individuals were included in the study, 18 with SCH, 18 with overt hypothyroidism (OH), and 18 healthy controls (HC). The carotid intima-media thickness was measured in each group. In SCH, follow-up was performed at three and six months after the start of levothyroxine. Results: The mean age of the total population at baseline was 35.8 years. The median TSH in SCH was 6.15 µIU/ml. The carotid intima-media thickness was greater in SCH in comparison to the HC group (Right common carotid artery [RCCA, mm]: 0.486 ± 0.106 and 0.413 ± 0.075 in SCH and HC, respectively, p=0.01. Left common carotid artery [LCCA, mm]: 0.511±0.144 and 0.427±0.090 in SCH and HC, respectively, p=0.03). In patients with SCH, there was a decrease in the carotid intima-media thickness after treatment with levothyroxine (RCCA and LCCA p <0.05 at 3 and 6 months). Conclusions: There is an association between an increase in the carotid intima-media thickness in patients with SCH in comparison to HC, even with a TSH <10 µIU/ml. The increase reversed with levothyroxine therapy. Its association with important cardiovascular outcomes remains uncertain and should be evaluated in future studies.

Comparison of Common Carotid Artery Intima-Media Thickness between Subclinical Hypothyroidism and Euthyroidism

2006 ◽  
Vol 21 (6) ◽  
pp. 490 ◽  
Author(s):  
Kyung-Sun Park ◽  
Jung-Im Rue ◽  
Soo-Kyung Kim ◽  
In-Jae Kim ◽  
Sang-Wook Lim ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Subclinical Hypothyroidism ◽  
Common Carotid Artery ◽  
Intima Media Thickness ◽  
Media Thickness

scholarly journals Carotid Intima‐Media Thickness and the Risk of Sudden Cardiac Death: The ARIC Study and the CHS

2020 ◽  
Vol 9 (19) ◽  
Author(s):  
Takeki Suzuki ◽  
Wanmei Wang ◽  
Anthony Wilsdon ◽  
Kenneth R. Butler ◽  
Selcuk Adabag ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Cardiac Death ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cardiovascular Health Study ◽  
Media Thickness ◽  
Increased Risk ◽  
Aric Study

Background Sudden cardiac death (SCD) is associated with severe coronary heart disease in the great majority of cases. Whether carotid intima‐media thickness (C‐IMT), a known surrogate marker of subclinical atherosclerosis, is associated with risk of SCD in a general population remains unknown. The objective of this study was to investigate the association between C‐IMT and risk of SCD. Methods and Results We examined a total of 20 862 participants: 15 307 participants of the ARIC (Atherosclerosis Risk in Communities) study and 5555 participants of the CHS (Cardiovascular Health Study). C‐IMT and common carotid artery intima‐media thickness was measured at baseline by ultrasound. Presence of plaque was judged by trained readers. Over a median of 23.5 years of follow‐up, 569 participants had SCD (1.81 cases per 1000 person‐years) in the ARIC study. Mean C‐IMT and common carotid artery intima‐media thickness were associated with risk of SCD after adjustment for traditional risk factors and time‐varying adjustors: hazard ratios (HRs) with 95% CIs for fourth versus first quartile were 1.64 (1.15–2.63) and 1.49 (1.05–2.11), respectively. In CHS, 302 participants developed SCD (4.64 cases per 1000 person‐years) over 13.1 years. Maximum C‐IMT was associated with risk of SCD after adjustment: HR (95% CI) for fourth versus first quartile was 1.75 (1.22–2.51). Presence of plaque was associated with 35% increased risk of SCD: HR (95% CI) of 1.37 (1.13–1.67) in the ARIC study and 1.32 (1.04–1.68) in CHS. Conclusions C‐IMT was associated with risk of SCD in 2 biracial community‐based cohorts. C‐IMT may be used as a marker of SCD risk and potentially to initiate early therapeutic interventions to mitigate the risk.

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