Difficulty in Diagnosing Peritoneal Fluid Cytology in Ovarian Yolk Sac Tumor Cases

Objective : This article objective is to describe cytology diagnosis difficulties of yolk sac tumors of the ovary.Method : Case reports and literature review.Case : The author reports the case of a 24 year old woman who complained of an enlarged stomach. Serum AFP increased to 16,519.7 U/mL. Ultrasound examination revealed solid and irregular mass of ovarian, so the conclusion was suspect ovarian carcinoma. Conclusion of CT scan examination was a solid ovarian tumor. The working diagnosis was suspect ovarian carcinoma. Optimal debulking was performed, accompanied by taking a sample from the peritoneal rinse fluid. Microscopic examination of peritoneal fluid showed the distribution and group of cells with pleomorphic nuclei, partly hyperchromatic, partly vesicular with coarse chromatin and prominent nucleoli. There were also cells with polygonal nuclei, small nuclei, basophilic and vacuole cytoplasm with a mucoid background. These cells formed a solid arrangement. Conclusion from these features was carcinoma metastases to the peritoneal fluid. Microscopic examination from tumor tissue sample showed an ovarian yolk sac tumor appearance.Conclusion : Cytologic examination of peritoneal fluid in cases of ovarian yolk sac tumor is quite difficult to determine the diagnosis. This is due to the microscopic appearance of tumor cells which often looks like a carcinoma and limited literature about this tumors in the peritoneal fluid.Keywords: Yolk sac tumor, ovary,

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Role of Radiotherapy in Recurrent Intra-Abdominal Yolk Sac Tumor

Case Reports in Oncology ◽

10.1159/000517022 ◽

2021 ◽

pp. 1010-1018

Author(s):

Marhendra Satria Utama ◽

Andi Kurniadi ◽

A.A. Citra Yunda Prahastiwi ◽

Antony A. Adibrata

Keyword(s):

Case Reports ◽

Yolk Sac ◽

Yolk Sac Tumor ◽

Appropriate Treatment ◽

Curative Radiotherapy ◽

Chief Complaints ◽

Abdominal Mri ◽

Malignant Germ Cell Tumor

Yolk sac tumor (YST) is a rare malignant germ cell tumor with no appropriate treatment strategy to date. However, patients are treated on a case-to-case basis as per various case reports that have been published. Here, we present a case of 27-year-old female patient who presented to us with chief complaints of severe abdominal pain associated with leucorrhea. She previously had a similar pain episode, which was then evaluated by a multidisciplinary team. She was diagnosed with YST. After that, she underwent 6 cycles of chemotherapy, but there was no improvement. Then the medical oncologist referred her to performed radiotherapy. Then, the radiation oncologist decided to give her curative radiotherapy of 3D-CRT. After completing her sessions, she felt better and clinically improving. After that, she was discharged and scheduled a follow-up visit for first evaluation. At her follow-up visit, she was feeling well, and we decided to have an abdominal MRI.

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Two Cases of Primary Yolk Sac Tumor of the Liver in Childhood: Case Reports and Literature Review

Pediatric and Developmental Pathology ◽

10.2350/08-09-0521.1 ◽

2009 ◽

Vol 12 (5) ◽

pp. 410-416 ◽

Cited By ~ 9

Author(s):

Mikako Warren ◽

Karen S. Thompson

Keyword(s):

Liver Biopsy ◽

Literature Review ◽

Tumor Cells ◽

Case Reports ◽

Primary Source ◽

Yolk Sac ◽

Yolk Sac Tumor ◽

Recurrent Tumor ◽

Normal Range ◽

Characteristic Features

Primary yolk sac tumor of the liver is an extremely rare neoplasm, with fewer than 20 cases reported. We evaluated 2 pediatric cases (21-month-old and 23-month-old female patients), who presented with liver masses and markedly raised serum α-fetoprotein (AFP). One patient received a partial hepatectomy and another patient underwent a liver biopsy, both of which showed characteristic features of yolk sac tumor, with tumor cells staining strongly positive for AFP. There was no evidence of an extrahepatic primary source. Both of our patients have been healthy, without evidence of recurrent tumor, and their AFP level remains in the normal range after their chemotherapeutic treatments.

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A Case Report of Yolk Sac Tumor in Cerebellar Hemisphere and Review of Literature

10.21203/rs.3.rs-38769/v1 ◽

2020 ◽

Author(s):

Yuting Zhang ◽

Lusheng Li ◽

Ling He

Keyword(s):

Case Report ◽

Histopathological Examination ◽

Case Reports ◽

Yolk Sac ◽

Alpha Fetoprotein ◽

Yolk Sac Tumor ◽

Cerebellar Hemisphere ◽

Review Of Literature ◽

Intracranial Germ Cell Tumor ◽

The Right

Abstract Background: Yolk sac tumor also known as endodermal sinus tumor, is a rare intracranial germ cell tumor. We reported a case of yolk sac tumor in cerebellar hemisphere, and reviewed associated literatures. The majority of tumor locations are near the midline. On review of literature, very few case reports of intracranial yolk sac tumor have been published, and there is only one case report has described a yolk sac tumor arising from the cerebellum. Case presentation: A two years old boy admitted to our hospital due to headache and unsteady gait for six days. CT and MRI demonstrated a tumor in the right cerebellar hemisphere, and the blood and cerebrospinal fluid alpha-fetoprotein were found increased. It was diagnosed as yolk sac tumor after operation comfirmed by histopathological examination. Postoperative chemotherapy was performed, and the patient suffered no tumor recurrence one year and a half after the surgery. Conclusions: The clinical characteristics and imaging diagnosis of intracranial yolk sac tumor are lack of specificity, the comfirmed diagnosis is depending on the combination of elevated alpha-fetoprotein and histopathological examination.

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Unusual Presentations of Gynecologic Tumors: Extragonadal Yolk Sac Tumor of the Vulva

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2016-0151-sa ◽

2016 ◽

Vol 141 (2) ◽

pp. 293-297 ◽

Cited By ~ 7

Author(s):

Elizabeth D. Euscher

Keyword(s):

Germ Cell ◽

Case Reports ◽

Germ Cell Tumors ◽

Yolk Sac ◽

Cell Tumor ◽

Yolk Sac Tumor ◽

Small Series ◽

Gynecologic Tumors ◽

Malignant Germ Cell Tumor ◽

Extragonadal Germ Cell Tumors

Extragonadal germ cell tumors are uncommon, and although they morphologically resemble their gonadal counterparts, unexpected gonadal presentation increases the potential for erroneous diagnoses. Yolk sac tumor is a malignant germ cell tumor characterized by an extraembryonic yolk sac line of differentiation, and relative to other germ cell tumors, is characterized by varied and diverse histologic patterns. When occurring outside of typical age parameters or in extragonadal locations, the histologic variability of yolk sac tumor and its tendency to mimic somatic tumors pose diagnostic challenges. Because extragonadal yolk sac tumor of the vulva is very rare, with only isolated case reports and small series in the literature, it is often not considered in the differential diagnosis. As both prognosis and management of yolk sac tumor differ significantly from those of somatic tumors, accurate diagnosis is essential. This review discusses histologic features of extragonadal yolk sac tumor, addresses somatic tumors arising in the vulva for which yolk sac tumor may be confused, and provides guidance with respect to the use of immunohistochemistry in the diagnosis of yolk sac tumor.

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Case Reports: Primary Yolk Sac Tumor of the Prostate in a Patient With Klinefelter's Syndrome

The Journal of Urology ◽

10.1016/s0022-5347(01)67643-2 ◽

1995 ◽

Vol 153 (3S) ◽

pp. 1066-1069 ◽

Cited By ~ 13

Author(s):

Howard P. Tay ◽

Mohamed Bidair ◽

Ahmed Shabaik ◽

James H. Gilbaugh ◽

Joseph D. Schmidt

Keyword(s):

Case Reports ◽

Yolk Sac ◽

Yolk Sac Tumor ◽

Klinefelter’S Syndrome ◽

Klinefelter's Syndrome

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Yolk Sac Tumor

10.32388/a1uh70 ◽

2020 ◽

Author(s):

Keyword(s):

Yolk Sac ◽

Yolk Sac Tumor

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TUMOR GANAS OVARIUM RESIDIF METASTASIS KARSINOMA MUSIN KE UMBILIKUS, PERITONEUM, DAN CAIRAN ASITES TANPA DITEMUKAN TANDA KEGANASAN PADA PEMERIKSAAN HISTOPATOLOGIS PASCA OPERATIF SEBELUMNYA

JOURNAL OBGIN EMAS ◽

10.25077/aoj.3.2.130-136.2019 ◽

2019 ◽

Vol 3 (2) ◽

pp. 130-136

Author(s):

Arif Fadillah ◽

Andi Friadi

Keyword(s):

Ovarian Carcinoma ◽

Ovarian Tumor ◽

Malignant Tumors ◽

Histopathological Examination ◽

Ovarian Tumors ◽

Postoperative Chemotherapy ◽

Definitive Treatment ◽

Malignant Ovarian Tumor ◽

Patient Will ◽

Optimal Debulking

Background : Malignant ovarian tumor are still the number one cause of death and the second most of incidents for gynecological malignant tumors. The principles of management of ovarian cancer are the same as the principles of handling other malignant diseases, for the treatment of primary lesions operatively and the handling of potential sites of tumor metastases with chemotherapy. Histopathological examination is still considered a gold standard for diagnosis and definitive treatment of malignant ovarian tumors. If histopathologic results are obtained, then the patient will be planned to undergo postoperative chemotherapy. The mismatch between the preoperative and intraoperative clinical features, and the results of postoperative histopathological examination is a problem in managing cases of ovarian malignant tumors.Objective : Report a case of residive ovarian carcinoma with no appearance of malignancy marker in the previous postoperative histopathological examination.Method : Case reportCase : We report the case of a 45-year-old woman with a history of two previous laparotomy. The first operation was carried out in February 2014 on the indication of an extra ovarian cyst, resulting in the impression of a "Follicular Cysts" based on histopathological examination. The second operation was performed in March 2015, performed surgical staging tumors with an indication of malignant ovarian tumors with clinical metastases, but from histopathological examination it was found that "Cystadenoma Ovarii Muscinosum Multiloculare" and "no visible signs of malignancy", so the patient was not managed with postoperative chemotherapy. In April 2019 patients came with complaints of new mass growth, from CT-Scan and USG investigations there was a suspicious impression of a residive ovarian tumor with metastases into the omentum and massive ascites. On May 16, 2019 an optimal debulking was performed with the findings of residive mass, ascites, and mass metastases in the intra operative peritoneum. From the results of histopathological examination, it was found that "Muscinous Carcinoma with metastases to the umbilicus, peritoneum, and ascitic fluidKeywords: Malignant residive ovarian tumor, mucinous ovarian carcinoma

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