Retrospektywna analiza przypadku wzmożonej hemolizy u pacjentki z opóźnioną hemolityczną reakcją poprzetoczeniową spowodowaną przeciwciałami anty-K

2018 ◽  
Vol 21 (2) ◽  
Author(s):  
Bożena Andrys ◽  
Katarzyna Korybalska
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Genetic Disorders ◽  
Hematological Parameters ◽  
Transfusion Reaction ◽  
Ferritin Concentration ◽  
Packed Red Blood Cells ◽  
Human Red Blood Cells ◽  
Hemolytic Transfusion Reaction ◽  
Life Threatening

Hyperhemolysis is a life-threatening undesirable post-transfusion reaction characterized by a decrease in hemoglobin (Hb), hematocrit (Hct), reticulocytopenia and increase in ferritin concentration. It usually occurs in patients with hemoglobinopathies, rarely in people without genetic disorders of human red blood cells. The case concerns a 79-year-old woman who, due to a trophic ulcer and erysipelas, received one unit of kell positive packed red blood cells (pRBC). The patient did not exhibit symptoms of hypoxia despite the reduced value of hematological parameters (Hb: 10.4 g/dl, Hct: 31%). Delayed hemolytic transfusion reaction (DHTR) occurred after 11 days, with the presence of anti-K antibodies (Hb: 6.1 g/dl, Hct: 17%). Despite transfusion of three pRBC properly selected against patient’s antigens, only a transient increase in Hb and Hct was observed (Hb: 8.1 g/dl, Hct: 22%). These parameters rapidly decreased within 18 hours (Hb: 6.7 g/dl, Hct: 18%). The patient died due to circulatory and respiratory failure.

Massive Transfusion

2018 ◽  
pp. 169-180
Author(s):  
Jay Berger
Keyword(s):  
Red Blood Cells ◽  
Blood Volume ◽  
Blood Cells ◽  
Massive Transfusion ◽  
Fresh Frozen Plasma ◽  
Metabolic Complications ◽  
Packed Red Blood Cells ◽  
Fresh Frozen ◽  
Life Threatening ◽  
Frozen Plasma

Massive transfusion is defined as transfusion of 3 units of packed red blood cells in less than 1 hour in an adult, replacement of more than 1 blood volume in 24 hours, or replacement of more than 50% of blood volume in 3 hours. Massive transfusion protocols are implemented in cases of life-threatening hemorrhage after trauma, during a surgical procedure, or during childbirth. These protocols are intended to minimize the adverse effects of hypovolemia, dilutional anemia, metabolic complications, and coagulopathy with early empiric replacement of blood products and transfusion of fresh frozen plasma, platelets, and packed red blood cells in a composition that approximates that of whole blood.

A Hemolytic Transfusion Reaction Caused by an Unexpected Leb Antibody

2021 ◽  
Author(s):  
Alexander A Delk ◽  
Richard R Gammon ◽  
Harold Alvarez ◽  
Nancy Benitez ◽  
Frieda Bright
Keyword(s):  
Sickle Cell Disease ◽  
Red Blood Cells ◽  
Black Male ◽  
Blood Cells ◽  
Reference Laboratory ◽  
Transfusion Reaction ◽  
Cell Disease ◽  
Hemolytic Transfusion Reaction ◽  
History Of ◽  
Possible Cause

Abstract A Black male patient aged 21 years with a history of sickle cell disease and HIV was admitted to the hospital with vaso-occlusive crisis. A transfusion reaction was called after the patient developed a fever (39.5°C), tachycardia, chills, and hematuria after receiving 300 mL of red blood cells. A posttransfusion specimen was submitted to the Immunohematology Reference Laboratory for investigation. Antibody identification revealed an anti-Leb as the probable cause of the immediate acute hemolytic transfusion reaction. Lewis antibodies are considered clinically insignificant. This case shows the importance of considering cold antibodies, including Lewis antibodies, as a possible cause of an acute hemolytic transfusion reaction.

Genetic disorders of human red blood cells

JAMA ◽  
1975 ◽  
Vol 233 (11) ◽  
pp. 1184-1188
Author(s):  
E. Beutler
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Genetic Disorders ◽  
Human Red Blood Cells

scholarly journals The Entry of Sodium into Human Red Blood Cells in Vivo

1966 ◽  
Vol 50 (1) ◽  
pp. 75-88 ◽  
Author(s):  
L. J. Beilin ◽  
D. Eyeions ◽  
G. Hatcher ◽  
G. J. Knight ◽  
A. D. Munro-Faure ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Compartmental Analysis ◽  
Analogue Computer ◽  
Packed Red Blood Cells ◽  
Human Red Blood Cells ◽  
In Series

The kinetics of sodium, movement into human red blood cells has been studied in vivo with 24Na. When human serum albumin-131I is used to measure the percentage of plasma trapped in the packed red blood cells after centrifugation, approximately 30 % of red blood cell sodium is found to equilibrate immediately with plasma. It is concluded that this immediately exchangeable compartment of red blood cell sodium is an experimental artefact, associated with the use of labeled albumin for measuring plasma trapping. This immediately exchangeable fraction disappears when sucrose-14C is used to measure plasma trapping. The experimental results were examined by compartmental analysis, using an analogue computer. The results obtained, when plasma trapping was measured with sucrose-14C could be simulated by the use of models containing two compartments, arranged in series or in parallel. The errors of the techniques used and the possible physical basis for the results are discussed.

Postinjury Life Threatening Coagulopathy: Is 1:1 Fresh Frozen Plasma: Packed Red Blood Cells the Answer?

2008 ◽  
Vol 65 (2) ◽  
pp. 261-271 ◽  
Author(s):  
Jeffry L. Kashuk ◽  
Ernest E. Moore ◽  
Jeffrey L. Johnson ◽  
James Haenel ◽  
Michael Wilson ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Fresh Frozen Plasma ◽  
Packed Red Blood Cells ◽  
Fresh Frozen ◽  
Life Threatening ◽  
Frozen Plasma
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