Assessment of efficacy of laryngotracheal reconstruction with autogenous rib cartilage graft

Introduction. Subglottic stenosis may lead to respiratory failure, especially in newborns and small children. It is the most common indication for tracheostomy in order to maintain airway patency in this age group. Subglottic stenosis requires surgical treatment. Laryngotracheal reconstruction with autogenous rib cartilage graft is one of the many treatment methods. Aim. The aim of the study was to assess of efficacy of laryngotracheal reconstruction with autogenous rib cartilage graft. Material and methods. Clinical data of 8 children operated for subglottic stenosis has been analysed. The severity of stenosis was assessed during the endoscopic examination with the Myer?Cotton Grading System. The efficacy of treatment was understood as a possibility of decannulation. Results. The study group included 8 patients: 6 boys and 2 girls. All the children had been born prematurely between the 24th and 34th week of pregnancy and were intubated in the early neonatal period. In 5 cases, decannulation followed, and in 3 cases, the treatment proved to be not effective enough, as the children had additional health problems. Conclusions. Prematurely born children intubated in the early neonatal period are at risk of post-intubation subglottic stenosis. Laryngotracheal reconstruction with autogenous rib cartilage graft is an effective treatment method. Treatment outcomes are also dependent on the overall health status of the patient and coexisting tracheal lesions.

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Rib Cartilage Grafts for the Treatment of Posterior Glottic and Subglottic Stenosis in Children

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948809700513 ◽

1988 ◽

Vol 97 (5) ◽

pp. 506-511 ◽

Cited By ~ 46

Author(s):

George H. Zalzal

Keyword(s):

Surgical Treatment ◽

Endotracheal Intubation ◽

Exercise Tolerance ◽

Cricoid Cartilage ◽

Voice Quality ◽

Subglottic Stenosis ◽

Cartilage Graft ◽

Rib Cartilage ◽

Single Procedure ◽

Open Surgical Treatment

Posterior glottic and subglottic stenosis from endotracheal intubation in children can be managed endoscopically with varying success. Open surgical treatment offers a better potential for correction with a single procedure in moderate and severe cases. The open method consists of splitting the scar and cricoid cartilage posteriorly to the level of the interarytenoid muscle, then stenting the incised cricoid open with a rib cartilage graft. Use of this method is described, and results in 12 cases are reported. Decannulation was achieved in ten patients. In all patients who were decannulated, good exercise tolerance, freedom from aspiration, and an adequate voice quality were achieved.

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Auricular Cartilage Grafts in Laryngotracheal Reconstruction

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348949310200402 ◽

1993 ◽

Vol 102 (4) ◽

pp. 247-254 ◽

Cited By ~ 38

Author(s):

Rodney P. Lusk ◽

D. Richard Kang ◽

Harlan R. Muntz

Keyword(s):

Costal Cartilage ◽

Subglottic Stenosis ◽

High Rate ◽

Cartilage Graft ◽

Auricular Cartilage ◽

Successful Management ◽

Cartilage Grafts ◽

Laryngotracheal Reconstruction ◽

Rate Of Success ◽

Costal Cartilage Graft

Introduction of the anterior cricoid split (decompression) and laryngotracheal reconstruction with costal cartilage graft has resulted in the successful management of many cases of subglottic stenosis. However, the procedure does not allow uniform extubation, and laryngotracheal reconstruction with costal cartilage may be too aggressive for neonates. We have explored the use of autogenous auricular cartilage graft in laryngotracheal reconstruction. Its high rate of success and low morbidity have enabled us to expand the indications. We report our experience in 23 patients with auricular cartilage grafts.

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Laryngotracheal reconstruction with autogenous rib cartilage graft for complex laryngotracheal stenosis and/or anterior neck defect

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-012-2256-4 ◽

2013 ◽

Vol 271 (2) ◽

pp. 317-322 ◽

Cited By ~ 10

Author(s):

Liu Zhi ◽

Wu Wenli ◽

Gao Pengfei ◽

Cui Pengcheng ◽

Chen Wenxian ◽

...

Keyword(s):

Laryngotracheal Stenosis ◽

Cartilage Graft ◽

Anterior Neck ◽

Rib Cartilage ◽

Laryngotracheal Reconstruction

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A Case of Congenital Glucose Galactose Malabsorption with a New Mutation in the SLC5A1 Gene

Journal of Pediatric Genetics ◽

10.1055/s-0040-1719161 ◽

2020 ◽

Author(s):

Hasan Akduman ◽

Dilek Dilli ◽

Serdar Ceylaner

Keyword(s):

Mutation Analysis ◽

Autosomal Recessive ◽

Glucose Transporter ◽

Neonatal Period ◽

Autosomal Recessive Disorder ◽

Homozygous Mutation ◽

New Mutation ◽

Early Neonatal Period ◽

Sodium Dependent ◽

Hypernatremic Dehydration

AbstractCongenital glucose-galactose malabsorption (CGGM) is an autosomal recessive disorder originating from an abnormal transporter mechanism in the intestines. It was sourced from a mutation in the SLC5A1 gene, which encodes a sodium-dependent glucose transporter. Here we report a 2-day-old girl with CGGM who presented with severe hypernatremic dehydration due to diarrhea beginning in the first hours of life. Mutation analysis revealed a novel homozygous mutation NM_000343.3 c.127G > A (p.Gly43Arg) in the SLC5A1 gene. Since CGGM can cause fatal diarrhea in the early neonatal period, timely diagnosis of the disease seems to be essential.

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