scholarly journals C16 Hydroxylation of 3.BETA.-Hydroxy-.DELTA.5-steroids during the Early Neonatal Period.

1997 ◽  
Vol 20 (12) ◽  
pp. 1295-1299 ◽  
Author(s):  
Noriko TAGAWA ◽  
Satoshi KUSUDA ◽  
Yoshiharu KOBAYASHI
Keyword(s):  
Neonatal Period ◽  
Early Neonatal Period

A Case of Congenital Glucose Galactose Malabsorption with a New Mutation in the SLC5A1 Gene

2020 ◽  
Author(s):  
Hasan Akduman ◽  
Dilek Dilli ◽  
Serdar Ceylaner
Keyword(s):  
Mutation Analysis ◽  
Autosomal Recessive ◽  
Glucose Transporter ◽  
Neonatal Period ◽  
Autosomal Recessive Disorder ◽  
Homozygous Mutation ◽  
New Mutation ◽  
Early Neonatal Period ◽  
Sodium Dependent ◽  
Hypernatremic Dehydration

AbstractCongenital glucose-galactose malabsorption (CGGM) is an autosomal recessive disorder originating from an abnormal transporter mechanism in the intestines. It was sourced from a mutation in the SLC5A1 gene, which encodes a sodium-dependent glucose transporter. Here we report a 2-day-old girl with CGGM who presented with severe hypernatremic dehydration due to diarrhea beginning in the first hours of life. Mutation analysis revealed a novel homozygous mutation NM_000343.3 c.127G > A (p.Gly43Arg) in the SLC5A1 gene. Since CGGM can cause fatal diarrhea in the early neonatal period, timely diagnosis of the disease seems to be essential.

FEATURES OF CARDIORESPIRATORY ADAPTATION OF LATER PRETERM INFANTS IN THE EARLY NEONATAL PERIOD

2018 ◽  
Vol 14 (66) ◽  
pp. 100
Author(s):  
G. A. Solovyova ◽  
V. I. Pokhilko ◽  
S. N. Tsvirenko ◽  
N. I. Gasyuk ◽  
Yu. Yu. Klimchuk
Keyword(s):  
Preterm Infants ◽  
Neonatal Period ◽  
Early Neonatal Period

Plasma 17-OH-Progesterone in Fullterm and Preterm Infants at Birth and during the Early Neonatal Period

1981 ◽  
Vol 15 (2) ◽  
pp. 65-71 ◽  
Author(s):  
B. Godó ◽  
H.K.A. Visser ◽  
H.J. Degenhart
Keyword(s):  
Preterm Infants ◽  
Neonatal Period ◽  
Early Neonatal Period

Features of modern clinical research blood analysis in the assessment of erythropoiesis in deep-premature newborns

2021 ◽  
Vol 66 (1) ◽  
pp. 26-34
Author(s):  
Galina Nikolaevna Kuzmenko ◽  
N. V. Kharlamova ◽  
S. B. Nazarov ◽  
E. A. Matveeva ◽  
Yu. A. Ivanenkova
Keyword(s):  
Neonatal Period ◽  
Venous Blood ◽  
Diagnostic Procedures ◽  
Blood Parameters ◽  
Blood Analysis ◽  
Iron Availability ◽  
Average Amount ◽  
Premature Newborns ◽  
Early Neonatal Period ◽  
Premature Babies

One of the urgent problems of nursing premature babies is the timely prediction, diagnosis and treatment of anemia, the frequency of which reaches 90%. Of particular importance is the study of reticulocytic blood parameters in deep-premature newborns, since the correct assessment of hemograms is crucial in the management of this category of children. To determine the characteristics of red blood cells and reticulocyte parameters of venous blood hemogram in premature newborns 24-32 weeks of gestation in the dynamics of the neonatal period. 111 newborns were examined at 24-32 weeks of gestation in the early neonatal period (on day 3-7) and at the age of 1 month of life. Along with standard diagnostic procedures, in accordance with current clinical recommendations and standards, 28 parameters of erythrocyte and reticulocyte hemogram parameters were determined for children. Venous blood was examined using an automatic hematological analyzer ADVIA 2120i, Siemens, USA. In deep-premature newborns in the early neonatal period, there is a high activity of erythropoiesis, respectively, the severity of respiratory and metabolic disorders with rejuvenation of reticulocytic subpopulations. Negative values of Delta hemoglobin were found against the background of a decrease in the average amount of hemoglobin in reticulocytes in children 24-27 weeks of gestation, which characterizes the lowest values of iron availability for erythropoiesis in this category of newborns. It is shown that a decrease in reticulocyte counts and normochromia in all examined newborns by the age of one month are accompanied by high levels of immature reticulocyte fraction, while a third of children still have limited iron availability for erythropoiesis.

Allergic altered reactivity in the early neonatal period

1982 ◽  
Vol 63 (4) ◽  
pp. 11-13
Author(s):  
A. G. Shamova ◽  
R. M. Bakhtiarova
Keyword(s):  
Enzymatic Activity ◽  
Social Factors ◽  
Peripheral Blood ◽  
Neonatal Period ◽  
Allergic Reactions ◽  
Blood Eosinophilia ◽  
Early Neonatal Period ◽  
Peripheral Blood Eosinophilia

In 138 newborns with toxic (allergic) erythema, the mediation of allergic reactions by social factors was established. On the 2nd day of life, an allergically altered reactivity is clinically manifested, which is also expressed by an altered picture of peripheral blood (eosinophilia, lymphocytosis) and indicators of the enzymatic activity of leukocytes.

Respiratory distress syndrome in neonates with extremely low body weight: non-invasive respiratory therapy in the early neonatal period

2020 ◽  
Vol 15 (6) ◽  
pp. 94-102
Author(s):  
O.V. Zavyalov ◽  
◽  
V.V. Marenkov ◽  
A.A. Dementyev ◽  
I.N. Pasechnik ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Body Weight ◽  
Intensive Care ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Neonatal Period ◽  
Respiratory Therapy ◽  
Non Invasive ◽  
Early Neonatal Period

The aim of this study was to evaluate the efficacy of non-invasive respiratory therapy using the method of dual positive airway pressure (DuoPAP) via nasal prongs performed in the intensive care unit and neonatal intensive care unit in premature newborns with extremely low body weight and respiratory distress syndrome in the early neonatal period. We conducted a retrospective analysis of 55 medical records of premature newborns treated in the intensive care unit of the Perinatal Center at S.S. Yudin City Clinical Hospital during the first 7 days of their life. We included patients treated between January 2018 and December 2019. All newborns had extremely low body weight (850 ± 149 g); mean gestational age was 28 ± 4 weeks; Apgar score at the first minute of life varied between 3 and 6; Silverman Anderson score (severity of respiratory disorders) was between 3 and 5 s. Standard examination was performed in accordance with current protocols developed by Russian and foreign specialists in neonatal medicine. A specially developed clinical protocol of the study was approved by the local ethics committee. Study participants were divided into 3 groups according to their type of spontaneous respiratory efforts, target level of preductal saturation, and Silverman Anderson score. Patients in Group I received synchronized intermittent mandatory ventilation (SIMV); patients in Group II received ventilation using DuoPAP via nasal prongs (if it was ineffective, we considered SIMV via tube); patients in group III received ventilation using DuoPAP only. In this study, we have identified indications and contraindications for initial and prolonged respiratory therapy with DuoPAP and developed main practical recommendations for effective and safe application of DuoPAP. The efficacy and safety of non-invasive respiratory therapy with DuoPAP via nasal prongs in extremely premature infants with respiratory distress syndrome in the early neonatal period is primarily determined by the newborn’s readiness for active spontaneous and productive respiratory movements, but not only by the compensated parameters of the acid-base state and gas composition of the capillary blood. The assessment of feasibility and limitations of non-invasive respiratory therapy with DuoPAP is an important step towards developing a clinical protocol for respiratory therapy in the early neonatal period in a neonatal intensive care unit; it will help to reduce the use of invasive lung ventilation. Key words: premature newborns, non-invasive respiratory therapy, respiratory distress syndrome, extremely low body weight

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