scholarly journals Sciatic Nerve Regeneration Using Collagen Tubes and Acellular Nerve Transplants in Rabbits (A comparative study)

2020 ◽  
Vol 25 (1) ◽  
pp. 10
Author(s):  
, AbdulJabbar Jameel Al-Samarae ◽  
Ali Ghanim Abdulla ◽  
Samira Abdulhussain Abdullah
Keyword(s):  
Sciatic Nerve ◽  
Nerve Graft ◽  
Ulcer Formation ◽  
Natural Polymers ◽  
Different Types ◽  
Post Operation ◽  
The Right ◽  
Sciatic Nerve Regeneration ◽  
Bone Exposure ◽  
Rat Nerve

The present study was conducted to evaluate and compare on anatomical bases between the different types of nerve graft, autograft, collagen tubes (natural polymers), and acellular epineurial nerve sheaths (biological conduits), which included acellular rabbit nerve graft and acellular rat nerve graft. Fourty local breaded rabbits were used and divided into four groups, each of ten rabbits. Then each group was subdivided again into two subgroups according to time of scarifying, which was after 45 days and 3 months post operation. All animals were undergone surgical operation on the right thigh and sciatic nerve of 8-10mm section was sectioned at the mid thigh, and the gap was replaced with the previous graft types comparison was made between the right (experimental) and left thighs (control) side. Samples from proximal, middle and distal stumps were taken to evaluate the regeneration process. The gross results revealed that, most animals developed ulcer formation and others with bone exposure. All animal groups of both periods showed delay latency. All these manifestations appeared as a subsequent of Wallerian degeneration with effects of nerve graft guidance extra cellular matrix, Schwann-macrophage interactions, neurons death and surgical scarring.   http://dx.doi.org/10.25130/tjps.25.2020.003

scholarly journals Salidroside promotes sciatic nerve regeneration following combined application epimysium conduit and Schwann cells in rats

2020 ◽  
Vol 245 (6) ◽  
pp. 522-531
Author(s):  
Jiaqi Li ◽  
Yongguang Zhang ◽  
Zhimin Yang ◽  
Jingxian Zhang ◽  
Ren Lin ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Western Blot ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Nerve Injury ◽  
Motor Function ◽  
Nerve Conduit ◽  
Combined Application ◽  
Post Operation ◽  
Sciatic Nerve Regeneration

Schwann cell and nerve conduit are crucial for nerve regeneration and re-myelination after peripheral nerves injury. To investigate the effects of Salidroside on autogenous epimysium conduit mixed with BD matrigel and RSC96 Schwann cells on an animal model with 5 mm sciatic nerve defect injury in rat, motor function, muscle reinnervation, immunohistochemical staining, retrograded tracing and Western blot were used in this study. The results showed that Salidroside enhanced the compound effects of epimysium conduit mixed with BD matrigel and RSC96 Schwann cells to improve the sciatic functional index and the gastrocnemius muscle weight ratio, which were better than EPM group at 8 weeks and 12 weeks post operation. Immunofluorescence and Western blot results of P75NTR showed that Salidroside improved the sciatic nerve regeneration, and retrograded tracing of CTB-Alexa 488 also supported that Salidroside was better to promote CTB tracer transporting from the distal nerve defect to the ipsilateral dorsal root ganglion and ventral horn of L3-L5 spinal cord on post-operation 8 weeks and 12 weeks. Our results demonstrated that Salidroside improved the effect of autogenous epimysium conduit mixed with BD matrigel and RSC96 Schwann cells on sciatic nerve regeneration in our study. Impact statement Peripheral nerve injury and regeneration remain a major challenge. Although nerve conduit and Schwann cells have been used to study the nerve regeneration, our results demonstrated that Salidroside improved the regenerative effect in a rat model with sciatic nerve injury model, following a combined application of autogenous epimysium conduit mixed with Schwann cells. Different concentrations of Salidroside combining autogenous epimysium conduit and Schwann cells were applied to compare the epimysium conduit group and the epimysium conduit combining Schwann cells group. Based on the results of motor function and muscle reinnervation evaluation, as well as neuronal tracing and expression of P75NTR, our study for the first time suggests that Salidroside may improve the regeneration effect on the sciatic nerve following a combined application of epimysium conduit and RSC96 Schwann cells in rats.

scholarly journals Dog sciatic nerve regeneration across a 30-mm defect bridged by a chitosan/PGA artificial nerve graft

Brain ◽  
2005 ◽  
Vol 128 (8) ◽  
pp. 1897-1910 ◽  
Author(s):  
Xiaodong Wang ◽  
Wen Hu ◽  
Yong Cao ◽  
Jian Yao ◽  
Jian Wu ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Nerve Graft ◽  
Sciatic Nerve Regeneration

scholarly journals Allogenic Adipose Derived Stem Cells Transplantation Improved Sciatic Nerve Regeneration in Rats: Autologous Nerve Graft Model

2018 ◽  
Vol 9 ◽  
Author(s):  
Ruslan Masgutov ◽  
Galina Masgutova ◽  
Liliya Mukhametova ◽  
Ekaterina Garanina ◽  
Svetlana S. Arkhipova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Nerve Graft ◽  
Adipose Derived Stem Cells ◽  
Stem Cells Transplantation ◽  
Sciatic Nerve Regeneration

scholarly journals The Sliding Scale between Usufruct and Ownership: The Example of Swedish Multi-Family Housing

Land ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 311
Author(s):  
Anna Granath Hansson ◽  
Peter Ekbäck ◽  
Jenny Paulsson
Keyword(s):  
Property Rights ◽  
General Level ◽  
Multifamily Housing ◽  
Different Types ◽  
Sliding Scale ◽  
Family Housing ◽  
The Right

This paper aims to elucidate the sliding scale between usufruct and ownership by applying a property rights framework to three Swedish forms of tenure in multifamily housing. The framework deconstructs the bundles of rights of rental, tenant-ownership and ownership to highlight commonalities and differences connected to the right to use and exclude, the right to transfer and the right to the value. It is concluded that the three tenure forms have many traits in common but that there are distinct differences in some areas, most notably in connection to the right to the value. The property rights framework applied in the study may be applicable also on a general level as a method to analyze and compare tenures of different types in different countries. Further, ways to improve the framework and cover more facets of outcomes of property rights patterns are suggested.

Sciatic Nerve Regeneration in Mice Induced by Transplantation of in Vitro Differentiated Nucleus Pulposus Progenitor Cells

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376535-s-0034-1376535
Author(s):  
T. Ishii ◽  
D. Sakai ◽  
T. Nukaga ◽  
J. Mochida
Keyword(s):  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Progenitor Cells ◽  
Nucleus Pulposus ◽  
Sciatic Nerve Regeneration

SCY1-Like 1-Binding Protein 1 (SCYL1BP1) Suppressed Sciatic Nerve Regeneration by Enhancing the RhoA Pathway

2015 ◽  
Vol 53 (9) ◽  
pp. 6342-6354 ◽  
Author(s):  
Weidong Zhang ◽  
Yonghua Liu ◽  
Xudong Zhu ◽  
Yi Cao ◽  
Yang Liu ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Binding Protein ◽  
Sciatic Nerve Regeneration
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