A Review on Emerging Floating Drug Delivery System

2016 ◽  
Vol 6 (4) ◽  
Author(s):  
Christe Mary M ◽  
Sasikumar Swamiappan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stomach Contents ◽  
Gastric Fluid ◽  
Dosage Forms ◽  
Gastric Residence Time ◽  
Advantages And Disadvantages ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

Presently, various approaches have been exploited in the prolongation of gastric residence time which includes floating drug delivery system (FDDS), swelling and expanding systems, bio-adhesive systems, modified shape systems and high density systems. Among various methods, floating drug delivery system is considered to be a predominant method. Gastric emptying of dosage forms is an extremely varying process and ability to extend and control the emptying time is a valuable resource for the dosage forms. This FDDS is having the ability to provides a solution for this purpose. The FDDS is a bulk density system lower than the gastric fluid, so that the rest will float on the stomach contents for a prolonged period of time and allowing the drug to release slowly at a desired rate from the system and intensifies the bio-availability of the drug having narrow absorption window. The main intension of writing this review on floating drug delivery system is to study the mechanism of flotation to acheive the gastric retention and to discuss briefly about the background of FDDS, advantages and disadvantages, application of FDDS and factors affecting the gastric retension time.

scholarly journals OVERVIEW ON FLOATING DRUG DELIVERY SYSTEM

2018 ◽  
Vol 10 (6) ◽  
pp. 65 ◽  
Author(s):  
Mirmeera Girish Niharika ◽  
Kannan Krishnamoorthy ◽  
Madhukar Akkala
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Forms ◽  
In Vivo Studies ◽  
Gastric Retention ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Systems

The principal objective behind the writing of this article on the floating drug delivery system (FDDS) was to systematize the recent literature with the core process of floatation in acquiring gastric retention. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The novel methodologies in FDDS include approaches to design a single unit and multiple-unit floating systems, the physiological and formulation variability affecting gastric retention along with the use of recently invented and developed polymers. This review also focuses on various in vitro techniques and in vivo studies in view of performance and application of floating systems. Floating dosage forms can be delivered in conventional forms like tablets, capsules with the addition of suitable ingredients along with the gas generating agent. This review also throws light on different techniques used in developing floating dosage forms along with current and novel advancements.

scholarly journals Floating Drug Delivery System

2021 ◽  
Vol 11 (3-S) ◽  
pp. 125-130
Author(s):  
Sanjay Thakur ◽  
Krishnappa Ramya ◽  
Deepak Kumar Shah ◽  
Khadga Raj
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Special Focus ◽  
Duration Of Action ◽  
Advantages And Disadvantages ◽  
Floating Drug Delivery ◽  
Floating Tablet ◽  
Floating Drug Delivery System ◽  
Absorption Window

Floating drug delivery system (FDDS) helps to improve the buoyancy property of the drug over the gastric fluids and hence maintain the longer duration of action. It is helpful in minimizing the dosing frequency. The density of dosage form must be less than the density of gastric contents (1.004 gm/ml) in FDDS. It may effervescent or non-effervescent system. The drugs having narrow absorption window in GIT is good candidate for the floating drug delivery system. The main objective of writing this review article is to compile the recent literature with special focus on classification, method of preparation, mechanism of action advantages and disadvantages.  Keywords: Floating drug delivery system, Sustained release, controlled release, Floating tablet, Evaluation, Application, Gastro-retentive drug delivery system.

DEVELOPMENT AND IN VITRO EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF ACECLOFENAC

INDIAN DRUGS ◽  
2016 ◽  
Vol 53 (09) ◽  
pp. 63-66
Author(s):  
J. C Rathi ◽  
◽  
V. Rathi ◽  
S. Tamizharasi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Entrapment Efficiency ◽  
Gastric Residence Time ◽  
Floating Drug Delivery ◽  
Drug Entrapment Efficiency ◽  
Floating Drug Delivery System ◽  
Central Composite

The objective of the present investigation is to attain optimized floating drug delivery system for aceclofenac by determining the effects of some important factors for the prolongation of gastric residence time. Floating microspheres were prepared by solvent diffusion–evaporation method using ethyl cellulose and hydroxypropylmethylcellulose. A central composite design was applied to optimize the formulation. An appropriate balance between the levels of the polymer and stirring speed was imperative to acquire maximum drug entrapment efficiency, sustained release of the drug, floating ability and adequate particle size.

scholarly journals Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system

2021 ◽  
Vol 7 (1) ◽  
pp. 035-044
Author(s):  
Kajal D. Chaudhari ◽  
Minakshee G. Nimbalwar ◽  
Nikita S. Singhal ◽  
Wrushali A. Panchale ◽  
Jagdish V. Manwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Floating Drug Delivery Systems ◽  
Gastro Retentive

Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in the past decades. These are the low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. GRFDDS is used to delay the residence time of delivery in stomach. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of mucoadhesion, floatation, sedimentation, expansion, modified shape systems or by the administration of pharmacological agents that delaying gastric emptying. This results in targeting of release of drug at a specific site for the systemic or local effects. GRDDS is used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. Some floating drug delivery systems have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses characterizations and application of gastro-retentive floating drug delivery systems.

scholarly journals A Comprehensive Review on Floating Drug Delivery System (FDDS)

2020 ◽  
Vol 10 (6) ◽  
pp. 174-182
Author(s):  
Aishwarya Rajendra Bhosale ◽  
Jitendra V Shinde ◽  
Rajashree S. Chavan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Special Focus ◽  
Gastric Emptying Rate ◽  
Principal Mechanism ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating System ◽  
Floating Drug Delivery System

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Current pharmaceutical scenario focuses on the formulation of floating drug delivery system (FDDS). FDDS are low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The aim of writing this review is to compile the current literature with special focus on the principal mechanism of floatation to attain gastric retention. Effervescent FDDS release CO2 gas, thus reduce the density of the system and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. The review briefly describes the mechanism, types of floating system, advantages, limitation, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and application of the system. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. Keywords: Floating drug delivery system, Absorption Window, Effervescent system, floating lag time.

scholarly journals Controlled Release of Oral Tetrahydrocurcumin from a Novel Self-Emulsifying Floating Drug Delivery System (SEFDDS)

2010 ◽  
Vol 12 (1) ◽  
pp. 152-164 ◽  
Author(s):  
Saipin Setthacheewakul ◽  
Wichan Kedjinda ◽  
Duangkhae Maneenuan ◽  
Ruedeekorn Wiwattanapatapee
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System
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