scholarly journals Necrolytic acral erythema as a manifestation of Crohn’s disease and celiac disease - A report of two cases

2020 ◽  
Vol 2 ◽  
pp. 130-133
Author(s):  
Anza Khader ◽  
Sukumarakurup Sreekanth ◽  
Shiny Padinjarayil Manakkattu ◽  
Nimmi John
Keyword(s):  
Crohn’S Disease ◽  
Celiac Disease ◽  
Hepatitis C ◽  
Crohn's Disease ◽  
Gastrointestinal Endoscopy ◽  
Diagnostic Marker ◽  
Hepatitis C Infection ◽  
First Case ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

Necrolytic acral erythema (NAE) is considered as a diagnostic marker of hepatitis C infection. Here, we report two cases of NAE in Crohn’s disease and celiac disease. Both the patients were seronegative for hepatitis C virus. The first case presented with recurrent diarrhea, weight loss, bullae on hyperpigmented plaque over extremities and gastrointestinal endoscopy and biopsy consistent with Crohn’s disease. The second case presented with recurrent diarrhea, vomiting, vesiculopustules and scaly plaques over extremities and duodenal biopsy diagnostic of celiac disease. NAE presents as papules and plaques with bullae over extremities, but tend to spare palms and soles. Our first patient had lesions on sole and the second patient had pustular lesions. To the best of our knowledge, there are no available reports of association of NAE with Crohn’s disease or celiac disease.

scholarly journals Treatment of Hepatitis C with Glecaprevir/Pibrentasvir in a Patient with Concurrent Stricturing Crohn’s Disease on Adalimumab

2021 ◽  
Vol 19 (2) ◽  
Author(s):  
Almoutaz Hashim
Keyword(s):  
Crohn’S Disease ◽  
Hepatitis C ◽  
Crohn's Disease ◽  
Sustained Viral Response ◽  
Viral Response ◽  
Key Words Hepatitis C ◽  
First Case ◽  
Key Words Hepatitis ◽  
Hcv Antibody ◽  
Polymerase Chain

A 22-year-old male with long standing, active Crohn’s disease on Adalimumab had presented with increasing levels of his transaminases. A full workup was conducted and the patient was found to have hepatitis C (HCV) based on a positive HCV antibody, polymerase chain reaction (PCR) and genotyping. He was started on a regimen of Glecaprevir/Pibrentasvir with excellent response defined by complete normalization of his transaminitis and an undetectable PCR at the end of 8 weeks of treatment and achieved sustained viral response at 12 weeks of treatment. This is the first case reporting the use of a combination of Glecaprevir/Pibrentasvir and Adalimumab in a patient with HCV and Crohn’s disease. Key words: Hepatitis C, Glecaprevir/Pibrentasvir, Crohn’s Disease

scholarly journals Necrolytic Acral Erythema

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Histopathological Examination ◽  
Inflammatory Cells ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Infection ◽  
Acral Erythema ◽  
Necrolytic Migratory Erythema ◽  
Necrolytic Acral Erythema

Background: Necrolytic acral erythema (NAE) is a rare dermatosis which has been regarded as an early cutaneous marker of hepatitis C virus infection. The clinical manifestasion of NAE is similar to necrolytic migratory erythema, psoriasis and tinea corporis. The difference is that the patients with NAE also suffer from hepatitis C virus infection. Case: A 59 year old woman came and complained about itchy erythematous-violaceous plaques since a year ago. The patient has a history of hepatitis C infection since 2 years ago. On the superior and inferior extremities region, there were erythematous-violaceous plaques witch is partially hyperpigmentation with well-demarcated border, multiple discretes with thin scales and lichenification. Histopathological examination of the lesion obtained psoriasiform, hyperkeratosis, neutophylic microabscess, epidermal necrosis, spongiosis and infiltration of inflammatory cells in the epidermis. Discussion: Necrolytic acral erythema has been reported exclusively in patients with hepatitis C and is thought to be pathognomonic of this infection. Acute lesions often show erythema with vesicles and flaccid bullae. Chronic lesions appear as erythematous to violaceous plaques with thick scales, erosions and crust. Acral sites are predominantly involved. The histopathological examination shows psoriasiform hyperplasia epidermal, neutrophylic microabscesses, dilatation of small vessels, parakeratosis and infiltration of inflammatory cells. In this case, the physical and histopathological examination support the diagnosis of NAE.

Leukocytoclastic vasculitis and necrolytic acral erythema in patients with hepatitis C infection: Do viral load and viral genotype play a role?

2010 ◽  
Vol 63 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Mohammad A. El-Darouti ◽  
Heba M. Mashaly ◽  
Eman El-Nabarawy ◽  
Amal M. Eissa ◽  
Mona R.E. Abdel-Halim ◽  
...  
Keyword(s):  
Viral Load ◽  
Hepatitis C ◽  
Leukocytoclastic Vasculitis ◽  
Viral Genotype ◽  
Hepatitis C Infection ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

Necrolytic acral erythema without hepatitis C infection

2009 ◽  
Vol 36 (3) ◽  
pp. 355-358 ◽  
Author(s):  
Yu-Hung Wu ◽  
Mei-Eng Tu ◽  
Chyou-Shen Lee ◽  
Yang-Chih Lin
Keyword(s):  
Hepatitis C ◽  
Hepatitis C Infection ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

Necrolytic acral erythema: A case not associated with hepatitis C infection

2008 ◽  
Vol 14 (6) ◽  
Author(s):  
Austin Liu ◽  
Christof P Erickson ◽  
Clay J Cockerell ◽  
Sylvia Hsu
Keyword(s):  
Hepatitis C ◽  
Hepatitis C Infection ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

scholarly journals An unusual case of chronic abdominal pain: an association between Celiac disease and Crohn’s disease

2021 ◽  
Vol 2021 (4) ◽  
Author(s):  
Leen Jamel Doya ◽  
Maria Naamah ◽  
Noura Karkamaz ◽  
Narmin Hajo ◽  
Fareeda Wasfy Bijow ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Abdominal Pain ◽  
Celiac Disease ◽  
Crohn's Disease ◽  
Histological Study ◽  
Gastrointestinal Diseases ◽  
Bowel Diseases ◽  
Oral Corticosteroids ◽  
History Of ◽  
High Caloric Diet

ABSTRACT Inflammatory bowel diseases (IBD) and Celiac disease (CeD) are immune-mediated gastrointestinal diseases with incompletely understood etiology. Both diseases show a multifactorial origin with a complex interplay between genetic, environmental factors, and some components of the commensal microbiota. The coexistence of celiac disease with Crohn’s disease is rarely reported in the literature. Here, we report a case of a 13-year-old Syrian male who presented with a history of abdominal pain, anorexia and pallor. CeD and Crohn’s disease was documented on gastrointestinal endoscopy and histological study. The patient was treated with a gluten-free, low fiber, high caloric diet, and a course of oral corticosteroids with an improvement in growth rate and abdominal pain.

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