Giant dumbbell C2C3 neurofibroma invading prebulbar cistern: Case report and literature review

Background: Neurofibromatosis 1 (NF1) has a broad spectrum of clinical manifestations, most typically involving café-au-lait spots and skin neurofibromas. Only 2% of patients with NF1 have symptomatic spinal tumors. Case Description: A patient with a previous diagnosis of NF1 presented with cervicalgia, dysphagia/mild dysphonia, gait alteration, and progressive hypoesthesia involving all four limbs. The magnetic resonance documented a giant dumbbell neurofibroma arising between the C2 and C3 levels which extended toward the foramen magnum, causing medullary and bulbar compression. The major challenge of surgical management was the enormous size and location this C2–C3 (5 cm × 4 cm × 5.1 cm) lesion. Conclusions: Compression of the foramen magnum attributed to a dumbbell giant spinal neurofibroma at the C2C3 level resulting in prebulbar cisterns should be among the differential diagnostic considerations for patients presenting with tetraparesis and underlying NF1.

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Spinal subdural hematoma after lumbar discectomy without dural injury – Is it possible? A case report and literature review

Surgical Neurology International ◽

10.25259/sni-32-2019 ◽

2019 ◽

Vol 10 ◽

pp. 66

Author(s):

Juliano Nery Navarro ◽

Francisco de Assis Ulisses Sampaio ◽

Mario Sergio Duarte Andrioli ◽

Francisco Ricardo Ribeiro ◽

Mariano Ebram Fiore ◽

...

Keyword(s):

Case Report ◽

Magnetic Resonance ◽

Literature Review ◽

Subdural Hematoma ◽

Rare Complication ◽

Lumbar Discectomy ◽

Diagnostic Study ◽

Case Description ◽

Lumbar Microdiscectomy ◽

Spinal Subdural Hematoma

Background: Spinal subdural hematoma (SSDH) is a rare complication of lumbar discectomy. Here, the authors reviewed 10 articles concerning the etiology, clinical, diagnostic, and surgical management of SSDH. Case Description: A postoperative SSDH occurred following a lumbar microdiscectomy in an 80-year-old patient in the absence of a dural injury. Conclusion: SSDH is a rare complication of lumbar discectomy and may even occur without a dural fistula. Notably, magnetic resonance is the diagnostic study of choice to identify this pathology that may then be appropriately managed.

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Circumferential intradural meningioma of the thoracic spine: Case report and literature review

Surgical Neurology International ◽

10.25259/sni_869_2020 ◽

2021 ◽

Vol 12 ◽

pp. 120

Author(s):

Sneha Bisht ◽

Raphael Laurente ◽

K Joshi George

Keyword(s):

Spinal Cord ◽

Case Report ◽

Literature Review ◽

Thoracic Spine ◽

Neurological Deficit ◽

Malignant Potential ◽

Spinal Tumors ◽

Case Description ◽

Intradural Extramedullary ◽

Spine Case

Background: Meningiomas are common intradural extramedullary spinal tumors with a predilection for the thoracic spine. They are mostly benign (90%), with only a few showing malignant potential. However, circumferential intradural meningiomas surrounding the spinal cord are exceptionally rare. Here, we present a 40-year-old patient with a T6-T7 circumferential lesion who underwent surgery. In addition, we reviewed three similar cases previously reported in the literature. Case Description: A 40-year-old female presented with paraparesis. Imaging demonstrated a T6-T7 thoracic circumferential intradural lesion, considered to most likely be a meningioma. At surgery, the posterolateral portion of the tumor was removed, but there was residual ventral disease. The tumor recurred several years later, and was again partially removed, now leaving her with a residual neurological deficit. Three similar cases of circumferential meningiomas, one cervical and two thoracic, were reported from the literature. Conclusion: Circumferential meningiomas pose unique and significant surgical challenges, particularly since resection of the posterolateral components is feasible, but some tumor may have to be left ventrally to avoid injury to the anterior spinal artery, that may recur.

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Computed tomography and magnetic resonance imaging findings of intrasellar schwannoma: A case report and literature review

Oncology Letters ◽

10.3892/ol.2016.4182 ◽

2016 ◽

Vol 11 (3) ◽

pp. 2315-2319 ◽

Cited By ~ 3

Author(s):

MENGQI LIU ◽

YU OUYANG ◽

FAJIN LV

Keyword(s):

Magnetic Resonance Imaging ◽

Computed Tomography ◽

Case Report ◽

Magnetic Resonance ◽

Literature Review ◽

Imaging Findings ◽

Resonance Imaging

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Epidermoid brain cysts: a case report and a literature review

Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) ◽

10.33920/med-01-2105-04 ◽

2021 ◽

pp. 358-371

Author(s):

Maksim Vladimirovich Shpagin ◽

Anton Viktorovich Yarikov ◽

Denis Nikolaevich Nikitin ◽

Igor Anatolievich Lobanov ◽

Ivan Aleksandrovich Laganin ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Cerebellopontine Angle ◽

Clinical Manifestations ◽

Complex Treatment ◽

Brain Pathology ◽

Epidermoid Cysts ◽

Histological Picture ◽

Clinical Observations ◽

Brain Cysts

The article is devoted to rare brain pathology, i.e. epidermoid cysts. The histological picture of the tumor is described; the classification is given. On the basis of our own clinical observations and a literature review, the features of the clinical manifestations of cholesteatoma of the cerebellopontine angle, modern approaches to the diagnosis and tactics of complex treatment are presented.

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Ornidazole-Induced Recurrent Encephalopathy in a Chinese Man: A Rare Case Report and Literature Review

Frontiers in Neurology ◽

10.3389/fneur.2021.706094 ◽

2021 ◽

Vol 12 ◽

Author(s):

Rong Tang ◽

Jia Liang ◽

Yuanfang Li ◽

Tingting Wu ◽

Yuhao Zhang ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Corpus Callosum ◽

Cerebellar Ataxia ◽

Drug Withdrawal ◽

Clinical Manifestations ◽

Good Prognosis ◽

Drug Discontinuation ◽

Imaging Features ◽

Mental Symptoms

Ornidazole-induced encephalopathy (OIE) is seldom seen in the clinic. In this study, we report a new case of a patient who had taken 1,000 mg ornidazole daily for nearly 4 years because of suspected diarrhea and proctitis and presented with subacute symptoms such as unsteady gait, slurred speech, and psychiatric disorder. These symptoms were significantly relieved 3 days after the patient stopped taking ornidazole. When he took this medicine again, however, similar symptoms occurred 4 months later, which were again reduced after 4 days of drug discontinuation. After the second onset, abnormal signals were identified around the aqueduct of the midbrain, around the fourth ventricle, and in the dentate nuclei of the cerebellum bilaterally. After 9 days of drug discontinuation, lesions disappeared in the magnetic resonance imaging (MRI) results. According to the clinical manifestations, imaging features, and the reduced symptoms after drug withdrawal, we clinically diagnosed the patient with OIE. This paper also reviews the literature on OIE. Only five cases (including our case) have been reported, all of whom presented with cerebellar ataxia and dysarthria and three with additional mental symptoms such as agitation and irritability. All five patients had abnormal lesions in the dentate nucleus of the cerebellum bilaterally, among whom four also had lesions in the corpus callosum and three around the periaqueduct of the midbrain. After withdrawal of ornidazole, the symptoms in all patients vanished or were alleviated, and three of them showed reduced or disappeared lesions in a head MRI reexamination. Overall, OIE has rarely been reported. Our case report and literature review show that the lesions in the cerebellum, corpus callosum, and brainstem can be reversed. The main manifestations of the lesions—cerebellar ataxia, dysarthria, and mental symptoms—quickly weaken or disappear after drug withdrawal, with good prognosis. Nevertheless, clear pathogenesis has yet to be further investigated.

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Partial Achilles Tendon Ruptures Associated with Fluoroquinolone Antibiotics: A Case Report and Literature Review

Foot & Ankle International ◽

10.1177/107110079601700811 ◽

1996 ◽

Vol 17 (8) ◽

pp. 496-498 ◽

Cited By ~ 62

Author(s):

William C. McGarvey ◽

Dishan Singh ◽

Saul G. Trevino

Keyword(s):

Magnetic Resonance Imaging ◽

Case Report ◽

Magnetic Resonance ◽

Literature Review ◽

Achilles Tendon ◽

Tendon Rupture ◽

Resonance Imaging ◽

Achilles Tendinitis ◽

Fluoroquinolone Antibiotics ◽

Tendon Ruptures

Fluoroquinolone antibiotics (such as ciprofloxacin, pefloxacin, ofloxacin, norfloxacin, temafloxacin, etc.) have recently been implicated in the etiology of Achilles tendinitis and subsequent tendon rupture. We report on a patient with bilateral partial Achilles tendon ruptures associated with ciprofloxacin therapy and present a review of the current literature on this increasingly recognized complication. Treatment with fluoroquinolones should be discontinued at the first sign of tendon inflammation so as to reduce the risk of subsequent rupture. Magnetic resonance imaging is useful in distinguishing between Achilles tendinitis and partial tendon rupture.

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Bilateral Extensive Ossification of the Posterior Petroclinoid Ligament: An Anatomical Case Report and Literature Review

Journal of Neurological Surgery Part A Central European Neurosurgery ◽

10.1055/s-0038-1666782 ◽

2018 ◽

Vol 80 (02) ◽

pp. 122-126 ◽

Cited By ~ 6

Author(s):

Robert Haładaj ◽

Michał Polguj ◽

Andrzej Żytkowski ◽

Mirosław Topol ◽

Grzegorz Wysiadecki

Keyword(s):

Case Report ◽

Literature Review ◽

Surgical Procedures ◽

Oculomotor Nerve ◽

Microsurgical Anatomy ◽

Case Description ◽

Detailed Data ◽

Dorello’S Canal ◽

Research Material ◽

Close Proximity

Background The posterior petroclinoid dural fold (commonly referred to as a ligament) forms the roof of the trigeminal porus and the roof of the petroclival venous confluence. It lies in close proximity to the oculomotor nerve that crosses it. Due to the low availability of research material, only a few cadaveric studies have been conducted on the microsurgical anatomy of the petroclinoid ligament in cases of its ossification. Thus our report complements earlier studies and provides detailed data on the spatial relationships between the ossified posterior petroclinoid ligament and the trigeminal, oculomotor, and abducens nerves, with special attention to the topographical relationships within the petroclival venous confluence and Dorello's canal. Case Description Bilateral massive ossification of the posterior petroclinoid ligament was observed during the dissection of a 76-year-old female cadaver. The presence of an osseous bridge over the trigeminal notch was also detected on the left side. No narrowing of the space occupied by the petroclival venous confluence was observed. However, the dural sheath of the oculomotor nerve was fixed much more than usual. Conclusions Because the ossification of the posterior petroclinoid ligament may be considered a factor influencing diagnostic and surgical procedures, neurosurgeons and neuroradiologists should be aware of this variation. Ossification of the posterior petroclinoid ligament may also potentially result in greater susceptibility of the oculomotor nerve to injury.

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Arthritis in children with LRBA deficiency – case report and literature review

Pediatric Rheumatology ◽

10.1186/s12969-019-0388-4 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 1

Author(s):

Rotem Semo Oz ◽

Melissa S. Tesher

Keyword(s):

Case Report ◽

Literature Review ◽

Rheumatic Disease ◽

Case Reports ◽

Clinical Manifestations ◽

Immune Dysregulation ◽

Joint Involvement ◽

Female Ratio ◽

Minimal Data ◽

Lrba Deficiency

Abstract Background Lipopolysaccharide (LPS)-responsive and beige like anchor (LRBA) deficiency is categorized as a subtype of common variable immune deficiency (CVID). A growing number of case reports and cohorts reveal a broad spectrum of clinical manifestations and variable phenotype expression, including immune dysregulation, enteropathy and recurrent infections. The association between rheumatic disease and CVID generally has been well established, arthritis has been less frequently reported and minimal data regarding its clinical features and characteristic in LRBA deficiency has been published. This case report and literature review evaluates the characteristics and features of arthritis in LRBA deficiency patients. Case presentation and review results Herein, we describe a unique case of LRBA deficiency first presented with poly articular arthritis. Alongside the report, a literature review focusing on LRBA deficiency, rheumatic disease and arthritis has been conducted. We reviewed 43 publications. Among these, 7 patients were identified with arthritis. Age of first presentation was six weeks to 3 years. Male to female ratio was 4/3. Two patients were diagnosed with polyarticular Juvenile idiopathic arthritis (JIA) and three with oligoarticular JIA. Each patient was found to have different genomic mutation. The treatment was diverse and included corticosteroids, cyclosporine, methotrexate, adalidumab and abatacept. Conclusion Joint involvement is variable in LRBA deficiency, hence it should always be kept in mind as a differential diagnosis for a patient with combination of juvenile arthritis and clinically atypical immune dysregulation and / or immunodeficiency.

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