scholarly journals The impact of zinc supplementation on the outcome of endoscopic sinus surgery and ciliary function of the nasal mucosa in children with chronic rhinosinusitis

2021 ◽  
pp. 73-82
Author(s):  
С.И. Алексеенко ◽  
А.В. Скальный ◽  
С.А. Карпищенко ◽  
С.А. Артюшкин ◽  
С.В. Барашкова ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Mucosa ◽  
Endoscopic Sinus Surgery ◽  
Inductively Coupled Plasma ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Sinus Surgery ◽  
Ciliary Activity ◽  
Ciliary Function ◽  
The Impact

Несмотря на указания на роль цинка в функции реснитчатого эпителия, данные относительно влияния коррекции обмена цинка на цилиарную функцию у пациентов с хроническим риносинуситом отсутствуют. Целью настоящего исследования явилась оценка эффективности хирургического лечения, активности мукоцилиарного аппарата, а также местной воспалительной реакции слизистой оболочки носа в послеоперационном периоде у детей с хроническим риносинуситом на фоне применения цинка. Методы. Обследовано 192 ребенка с хроническим риносинуситом, в лечении которых применялась эндоскопическая риносинусохирургия. Из них 131 ребенок в послеоперационном периоде получал стандартные назначения, тогда как 61 ребенок дополнительно получал цинк в суточной дозе 10 мг в течение 90 дней. Оценка концентрации цинка в сыворотке крови осуществлялась методом ИСП-МС. Для определения функции цилий использована видеоцитоморфометрия. Определение эффективности лечения осуществлялось с использованием опросника SNOT-20, а также шкал Лунд-Кеннеди и Лунд-Маккей. Результаты. Проведение эндоскопической операции приводило к достоверному снижению значений шкал SNOT-20, Лунд-Кеннеди и Лунд-Маккей у пациентов вне зависимости от приема цинка. В то же время, пациенты, принимавшие цинк, характеризовались достоверно меньшим риском ревизионной хирургии. Цинк также оказывал значительное влияние на функционирование реснитчатого эпителия. В частности, к 12-му месяцу наблюдения количество клеток с подвижными цилиями, частота биения цилий, длина цилий и выживаемость клеток у пациентов, принимавших цинк, превышала соответствующие показатели в контрольной группе. Повышение уровня цинка в организме также сопровождалось многократным снижением количества инфильтрирующих слизистую оболочку нейтрофилов и лимфоцитов. Заключение. Предполагается, что цинк ускоряет репаративные процессы в слизистой оболочке носа и обладает противовоспалительным действием. Despite the presence of certain indications of the role of zinc in ciliated epithelium functioning, data on the potential effect of Zn supplementation in ciliary function in patients with chronic rhinosinusitis are absent. The aim of this study was to evaluate the efficiency of surgical treatment, ciliary activity, as well as local inflammation of nasal mucosa in children with chronic rhinosinusitis undergoing functional endoscopic surgery. Methods. 192 pediatric patients with chronic rhinosinusitis were examined. 131 patients received standard postoperative prescriptions, whereas 61 children received 10 mg Zn daily for 90 days. Serum Zn concentrations were measured by inductively coupled plasma mass spectrometry. Ciliary function was evaluated by video cytomorphometry. Surgery efficiency was assessed with a SNOT-20 questionnaire, as well as with Lund-Kennedy and Lund-Mackay scales. Results. Functional endoscopic sinus surgery resulted in a significant decrease in total SNOT-20, Lund-Kennedy, and Lund-Mackay scores independent of Zn supplementation. At the same time, Zn supplemented patients had a significantly lower risk of revision surgery. Zn also had a significant impact on ciliary function. Specifically, up to the 12th mo postoperatively, Zn supplementation resulted in higher number of cells with motile cilia, ciliary beat frequency, ciliary length, and cell viability as compared to controls. Increased Zn status was also associated with a manyfold decrease in mucosal neutrophil and lymphocyte infiltration. Conclusions. It is proposed that Zn enhances reparative processes in nasal mucosa and possesses anti-inflammatory activity.

Ciliary function and sinonasal mucosal cytology in pediatric patients with chronic rhinosinusitis during a year after functional endoscopic sinus surgery

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
S. Alekseenko ◽  
S. Karpischenko ◽  
S. Artyushkin ◽  
S. Barashkova ◽  
I. Anikin
Keyword(s):  
Chronic Rhinosinusitis ◽  
Endoscopic Sinus Surgery ◽  
High Speed ◽  
Beat Frequency ◽  
Neutrophil Infiltration ◽  
Ciliary Beat Frequency ◽  
Substantial Improvement ◽  
Sinus Surgery ◽  
Cell Height ◽  
Ciliary Function

Background: The objective of the study is evaluation of ciliary function and mucosal cytology after endoscopic sinus surgery in children with chronic rhinosinusitis (CRS). Methodology: A total of 132 children with CRS who underwent endoscopic sinus surgery, as well as 15 healthy controls were involved in the study. In this follow-up study patients were examined preoperatively, as well as 3, 6, 9, and 12 months after endoscopic sinus surgery. Assessment of ciliary function and sinonasal mucosal cytology was performed using high-speed videomicroscopy. Lund-Kennedy, Lund-Mackay, and sinonasal outcome test 20 (SNOT20) scores were also evaluated. Results: Total SNOT-20, Lund-Mackay, and Lund-Kennedy values significantly decreased after sinus surgery. In contrast, ciliary function and mucosal cytology only tended to improve after 6 months. 9 months after surgery the number of ciliated cells, ciliary beat frequency, cell viability, and ciliary length were significantly higher than preoperatively. The most significant improvement of ciliary function and cell height was observed 12 months after operation, whereas epithelial dystrophy and neutrophil infiltration were significantly reduced. Conclusions: Substantial improvement was observed only in a year after surgery, whereas 0 to 3 months after the surgery ciliary function was severely impaired thus predisposing to recurrent sinusitis or other complications.

Altered Sinonasal Ciliary Dynamics in Chronic Rhinosinusitis

2006 ◽  
Vol 20 (3) ◽  
pp. 325-329 ◽  
Author(s):  
Bei Chen ◽  
Jeffrey Shaari ◽  
Steven Eau Claire ◽  
James N. Palmer ◽  
Alexander G. Chiu ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Adenosine Triphosphate ◽  
High Speed ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Ciliary Activity ◽  
Differential Interference Contrast Microscopy ◽  
Dynamic Regulation ◽  
Mucus Clearance ◽  
Persistent Inflammation

Background Although multiple etiologies contribute to the development of rhinosinusitis, a common pathophysiological sequelae is ineffective sinonasal mucociliary clearance, resulting in stasis of sinonasal secretions, with subsequent infection, and persistent inflammation. The respiratory cilia beat continually at a basal rate, while during times of stress, such as exercise or infection, ciliary beat frequency (CBF) increases, accelerating mucus clearance. Previous investigations have led to conflicting results with some authors reporting decreased CBF while others have found normal values of CBF in patients with chronic rhinosinusitis (CRS). Additionally, these studies have only analyzed basal CBF. The goal of this study was to compare the basal as well as the stimulated sinonasal CBF in patients with CRS versus controls. Methods A dual temperature controlled perfusion chamber, differential interference contrast microscopy, and high-speed digital video were used to analyze both basal and adenosine triphosphate (100 μM)–stimulated CBF in human sinonasal mucosal explants. Results Although no difference in basal CBF was detected between control and CRS patients, a marked difference in stimulated CBF was noted. Exogenously applied adenosine triphosphate resulted in a 50–70% increase of CBF in control tissue with a minimally observed CBF increase in explants from CRS patients. Conclusion Dynamic regulation of respiratory ciliary activity is critical for the respiratory epithelium to adapt to varying environmental situations. Thus, diminished or absent adaptation could predispose the sinonasal cavity to accumulation of inhaled infectious and noxious particulate matter resulting in infection/inflammation. Our findings suggest that CRS patients have decreased sinonasal ciliary adaptation to environmental stimuli.

Functional endoscopic sinus surgery in the management of chronic rhinosinusitis. An objective assessment

1991 ◽  
Vol 105 (10) ◽  
pp. 832-835 ◽  
Author(s):  
Valerie J. Lund ◽  
Mats Holmstrom ◽  
Glenis K. Scadding
Keyword(s):  
Endoscopic Sinus Surgery ◽  
Clinical Success ◽  
Objective Assessment ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Quantitative Evidence ◽  
Chronic Rhino Sinusitis ◽  
Ciliary Beat

AbstractConsiderable clinical success has been claimed for functional endoscopic sinus surgery but objective assessment of prospective series is lacking in the literature. Twenty-four patients with chronic rhino-sinusitis underwent assessment of symptoms by visual analogue scoring, nasomucociliary function by ciliary beat frequency, olfaction by qualitative olfactometry and nasal airway resistance by anterior rhinomanometry pre- and post-operatively. This demonstrated a significant improvement in all symptoms examined and in ciliary beat frequency. Quantitative olfaction and anterior rhinomanometry were not improved despite diminished symptoms. These results offer quantitative evidence of clinical improvement following functional endoscopic sinus surgery which supports the pathophysiological concepts on which the technique is based.

Nasal mucosa healing after endoscopic sinus surgery in chronic rhinosinusitis of elderly patients: role of topic alpha-tocopherol acetate

2016 ◽  
Vol 29 (S1) ◽  
pp. 191-195 ◽  
Author(s):  
Domenico Testa ◽  
Giuseppina Marcuccio ◽  
Giorgio Panin ◽  
Andrea Bianco ◽  
Domenico Tafuri ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Chronic Rhinosinusitis ◽  
Nasal Mucosa ◽  
Endoscopic Sinus Surgery ◽  
Alpha Tocopherol ◽  
Sinus Surgery ◽  
Tocopherol Acetate

Ciliary Beat Frequency, Olfaction and Endoscopic Sinus Surgery

ORL ◽  
1998 ◽  
Vol 60 (4) ◽  
pp. 202-205 ◽  
Author(s):  
Balegh Abdel-Hak ◽  
Andreas Gunkel ◽  
Georg Kanonier ◽  
Anneliese Schrott-Fischer ◽  
Hanno Ulmer ◽  
...  
Keyword(s):  
Endoscopic Sinus Surgery ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Sinus Surgery ◽  
Ciliary Beat

Objective assessment of endoscopic sinus surgery in the management of chronic rhinosinusitis: an update

1994 ◽  
Vol 108 (9) ◽  
pp. 749-753 ◽  
Author(s):  
Valerie J. Lund ◽  
Glenis K. Scadding
Keyword(s):  
Chronic Rhinosinusitis ◽  
Clinical Success ◽  
Subjective Evaluation ◽  
Objective Assessment ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Acoustic Rhinometry ◽  
Sinus Surgery ◽  
Ostiomeatal Complex ◽  
Ciliary Beat

AbstractWhilst clinical success of endoscopic surgery for chronic rhinosinusitis has necessarily depended primarily upon subjective evaluation, a range of objective techniques are now available which may facilitate our interpretation of results. A group of 200 patients underwent assessment of symptoms by sequential visual analogue scoring, olfaction by qualitative and quantitative testing, nasal airflow by forced inspiratory peak flow, anterior rhinomanometry, nasomucociliary function by ciliary beat frequency and nasal topography by acoustic rhinometry performed pre- and post-operatively. Significant improvement was demonstrated in all symptoms examined, olfactory tests and ciliary beat frequency whilst acoustic rhinometry provided an attempt to quantify the surgical cavities. These results offer an interesting perspective on the pathology of rhinosinusitis and the rationale for surgery within the ostiomeatal complex.

scholarly journals Pulmonary Function of Patients with Chronic Rhinosinusitis and the Impact of Endoscopic Sinus Surgery

OTO Open ◽  
2017 ◽  
Vol 1 (4) ◽  
pp. 2473974X1773875
Author(s):  
Ahmed M. Youssef ◽  
Osama G. Abdel-Naby Awad ◽  
Mohamed Taha
Keyword(s):  
Pulmonary Function ◽  
Chronic Rhinosinusitis ◽  
Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
The Impact

The effects of nasal lavage with betamethasone cream post-endoscopic sinus surgery: clinical trial

2017 ◽  
Vol 132 (2) ◽  
pp. 143-149 ◽  
Author(s):  
B Dawson ◽  
I Gutteridge ◽  
A Cervin ◽  
D Robinson
Keyword(s):  
Chronic Rhinosinusitis ◽  
Endoscopic Sinus Surgery ◽  
Safety Data ◽  
Serum Cortisol ◽  
Urinary Free Cortisol ◽  
Sinus Surgery ◽  
Nasal Irrigation ◽  
Free Cortisol ◽  
Cortisol Levels ◽  
The Impact

AbstractBackground:Steroid nasal irrigation for chronic rhinosinusitis patients following endoscopic sinus surgery reduces symptom recurrence. There are minimal safety data to recommend this treatment. This study evaluated the safety of betamethasone nasal irrigation by measuring its impact on endogenous cortisol levels.Methods:Participants performed daily betamethasone nasal irrigation for six weeks. The impact on pre- and post-intervention serum and 24-hour urinary free cortisol was assessed. Efficacy was evaluated using the 22-item Sino-Nasal Outcome Test.Results:Thirty participants completed the study (16 females and 14 males; mean age = 53.9 ± 15.6 years). Serum cortisol levels were unchanged (p = 0.28). However, 24-hour urinary free cortisol levels decreased (47.5 vs 41.5 nmol per 24 hours; p = 0.025). Sino-Nasal Outcome Test scores improved (41.13 ± 21.94 vs 23.4 ± 18.17; p < 0.001). The minimal clinical important difference was reached in 63 per cent of participants.Conclusion:Daily betamethasone nasal irrigation is an efficacious treatment modality not associated with changes in morning serum cortisol levels. The changes in 24-hour urinary free cortisol levels are considered clinically negligible. Hence, continued use of betamethasone nasal irrigation remains a viable and safe treatment option for chronic rhinosinusitis patients following functional endoscopic sinus surgery.

Sign in / Sign up

Export Citation Format

Share Document